PPARγ

Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
1307 Ciglitazone
Selective PPARγ agonist
4784 Edaglitazone
Potent and selective PPARγ agonist; antidiabetic
1664 GW 1929 hydrochloride
Selective PPARγ agonist. Orally active
3831 LG 100754
RXR:PPAR agonist; sensitizes PPARγ
2150 nTZDpa
Potent, selective PPARγ partial agonist
4124 Pioglitazone hydrochloride
Selective PPARγ agonist; antidiabetic agent
2306 15-deoxy-Δ-12,14-Prostaglandin J2
Endogenous PPARγ agonist
5325 Rosiglitazone
Potent and selective PPARγ agonist; antidiabetic agent.
3690 S26948
Selective PPARγ agonist; antidiabetic agent
5139 Telmisartan
PPARγ partial agonist; AT1 antagonist
3114 Troglitazone
Selective PPARγ agonist; antidiabetic agent

Antagonists

Cat No Product Name / Activity
1326 BADGE
PPARγ antagonist
4344 FH 535
PPARγ/δ antagonist; also inhibits Wnt/β-catenin signaling
1508 GW 9662
Selective PPARγ antagonist
2022 SR 202
Selective PPARγ antagonist; antidiabetic and antiobesity agent
2301 T 0070907
Highly potent and selective PPARγ antagonist

Other

Cat No Product Name / Activity
1110 Genistein
PPARγ ligand. Also estrogen receptor ligand and EGFR inhibitor
4409 SR 1664
High affinity PPARγ ligand; blocks Cdk5-dependent PPARγ phosphorylation

Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression. PPARγ is located primarily in the adipose tissue, lymphoid tissue, colon, liver and heart and is thought to regulate adipocyte differentiation and glucose homeostasis. PPARγ has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. The human gene encoding PPARγ has been localized to chromosome 3 (3p25).

External sources of pharmacological information for PPARγ :

    Literature for PPARγ

    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
    • Cell Cycle and DNA Damage Repair
    • Angiogenesis
    • Invasion and Metastasis
    Cardiovascular

    Cardiovascular Research Product Guide

    A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

    • Hypertension
    • Thrombosis and Hemostasis
    • Atherosclerosis
    • Myocardial Infarction
    • Ischemia/Reperfusion Injury
    • Arrhythmias
    • Heart Failure
    Nuclear Receptors

    Nuclear Receptors Product Listing

    A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

    • Androgen Receptors
    • Estrogen Receptors
    • Retinoic Acid Receptors
    • Retinoid X Receptors
    • Vitamin D Receptors

    PPARγ Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human PPARG NM_005037 Q86U60
    Mouse Pparg NM_001127330 P37238
    Rat Pparg NM_013124 O88275