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PPARγ

Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression.

Products
Background
Literature (4)
Gene Data

PPARγ Agonists
Cat. No. Product Name / Activity
1307 Ciglitazone
Selective PPARγ agonist
4784 Edaglitazone
Potent and selective PPARγ agonist; antidiabetic
1664 GW 1929 hydrochloride
Selective PPARγ agonist. Orally active
4124 Pioglitazone hydrochloride
Selective PPARγ agonist; antidiabetic agent
5325 Rosiglitazone
Potent and selective PPARγ agonist; antidiabetic agent
3114 Troglitazone
Selective PPARγ agonist; antidiabetic agent

Partial Agonists
Cat. No. Product Name / Activity
7423 INT 131
PPARγ partial agonist
2150 nTZDpa
Potent, selective PPARγ partial agonist
5139 Telmisartan
PPARγ partial agonist; AT1 antagonist

PPARγ Antagonists
Cat. No. Product Name / Activity
4344 FH 535
PPARγ/δ antagonist; also inhibits Wnt/β-catenin signaling
1508 GW 9662
Selective covalent PPARγ antagonist
6383 SR 16832
Dual site PPARγ inhibitor
2022 SR 202
Selective PPARγ antagonist; antidiabetic and antiobesity agent
2301 T 0070907
Highly potent and selective covalent PPARγ antagonist

Other
Cat. No. Product Name / Activity
1110 Genistein
PPARγ ligand. Also estrogen receptor ligand and EGFR inhibitor
5920 LG 100268
Activates RXR/PPARγ heterodimers; potent and selective RXR agonist
4409 SR 1664
High affinity PPARγ ligand; blocks Cdk5-dependent PPARγ phosphorylation

Related Targets

Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression. PPARγ is located primarily in the adipose tissue, lymphoid tissue, colon, liver and heart and is thought to regulate adipocyte differentiation and glucose homeostasis. PPARγ has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. The human gene encoding PPARγ has been localized to chromosome 3 (3p25).

External sources of pharmacological information for PPARγ :

Literature for PPARγ

Tocris offers the following scientific literature for PPARγ to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors
Epilepsy Poster

Epilepsy Poster

Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.

PPARγ Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human PPARG NM_005037 Q86U60
Mouse Pparg NM_001127330 P37238
Rat Pparg NM_013124 O88275