PPARγ

Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression.

Products
Background
Gene Data

PPARγ Agonists

Cat. No. Product Name / Activity
4784 Edaglitazone
Potent and selective PPARγ agonist; antidiabetic
1664 GW 1929 hydrochloride
Selective PPARγ agonist. Orally active
4124 Pioglitazone hydrochloride
Selective PPARγ agonist; antidiabetic agent
5325 Rosiglitazone
Potent and selective PPARγ agonist; antidiabetic agent
3114 Troglitazone
Selective PPARγ agonist; antidiabetic agent

Partial Agonists

Cat. No. Product Name / Activity
7423 INT 131
PPARγ partial agonist
2150 nTZDpa
Potent, selective PPARγ partial agonist

PPARγ Antagonists

Cat. No. Product Name / Activity
4344 FH 535
PPARγ/δ antagonist; also inhibits Wnt/β-catenin signaling
1508 GW 9662
Selective covalent PPARγ antagonist
6383 SR 16832
Dual site PPARγ inhibitor
2022 SR 202
Selective PPARγ antagonist; antidiabetic and antiobesity agent
2301 T 0070907
Highly potent and selective covalent PPARγ antagonist

Other

Cat. No. Product Name / Activity
1110 Genistein
PPARγ ligand. Also estrogen receptor ligand and EGFR inhibitor
5920 LG 100268
Activates RXR/PPARγ heterodimers; potent and selective RXR agonist

Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression. PPARγ is located primarily in the adipose tissue, lymphoid tissue, colon, liver and heart and is thought to regulate adipocyte differentiation and glucose homeostasis. PPARγ has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. The human gene encoding PPARγ has been localized to chromosome 3 (3p25).

External sources of pharmacological information for PPARγ :

PPARγ Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human PPARG NM_005037 Q86U60
Mouse Pparg NM_001127330 P37238
Rat Pparg NM_013124 O88275