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Submit ReviewMB 05032
Description: Potent FBPase inhibitor; promotes HSC expansion
Chemical Name: P-[5-[2-Amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]phosphonic acid
Purity: ≥98% (HPLC)
Biological Activity for MB 05032
MB 05032 is a potent FBPase inhibitor (EC50 values are 1.6, 29 and 61 nM for human liver FBPase, human muscle FBPase and rat liver FBPase). Promotes hematopoietic stem cell and progenitor cell expansion. Increases engraftment in primary NSG mice recipients. Also enhances myeloid and lymphoid chimerism in secondary NSG mouse recipients. Promotes glycolysis, glucose uptake and lactate production in umbilical cord blood CD34+ cells.
Compound Libraries for MB 05032
MB 05032 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for MB 05032
| M. Wt | 302.29 |
| Formula | C11H15N2O4PS |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 261365-11-1 |
| PubChem ID | 11289630 |
| InChI Key | XJMYIJPPDSZOPN-UHFFFAOYSA-N |
| Smiles | CC(CC1=C(C2=CC=C(P(O)(O)=O)O2)N=C(S1)N)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MB 05032
References for MB 05032
References are publications that support the biological activity of the product.
Guo et al (2018) Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis. Nat.Med. 24 360 PMID: 29377004
van Poelje et al (2011) Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes. Handb.Exp.Pharmacol. 203 279 PMID: 21484576
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Keywords: MB 05032, MB 05032 supplier, MB05032, potent, FBPase, inhibitors, fructose, 1, 6, bisphosphatase, diabetes, HSC, expansion, gluconeogenesis, hematopoietic, haematopoietic, stem, cells, Other, Transferases, Stem, Cell, Proliferation, Hematopoietic, Cells, 6618, Tocris Bioscience
Citations for MB 05032
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Currently there are no citations for MB 05032.
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