Troglitazone

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Cat.No. 3114 - Troglitazone | C24H27NO5S | CAS No. 97322-87-7
Description: Selective PPARγ agonist; antidiabetic agent
Alternative Names: Rezulin
Chemical Name: 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
Purity: ≥97% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (4)

Biological Activity

Selective PPARγ receptor agonist (EC50 values are 780 and 555 nM at murine and human PPARγ receptors respectively). Displays no activity at PPARα or PPARδ receptors. Antidiabetic agent; exerts potent glucose-lowering effects in insulin-resistant diabetic mice. Displays anti-invasive effect on human breast cancer cells; reduces migration, adhesion and spreading on fibronectin-coated plates. Also inhibits cell growth of hematopoietic cell lines. Inhibits lamellipodia formation and actin polymerization.

Compound Libraries

Troglitazone is also offered as part of the Tocriscreen Plus and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 441.54
Formula C24H27NO5S
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 97322-87-7
PubChem ID 5591
InChI Key GXPHKUHSUJUWKP-UHFFFAOYSA-N
Smiles CC1=C2C(CCC(COC3=CC=C(CC4C(NC(S4)=O)=O)C=C3)(C)O2)=C(C)C(O)=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.15 100
ethanol 4.42 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 441.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.32 mL 22.65 mL
5 mM 0.45 mL 2.26 mL 4.53 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Lee and Olefsky (1995) Acute effects of troglitazone on in vivo Ins action in normal rats. Metabolism 44 1166 PMID: 7666790

Kodera et al (2000) Ligand type-specific interactions of peroxisome-proliferator-activated receptor γ with transcriptional coactivators. J.Biol.Chem. 275 33201 PMID: 10944516

Willson et al (2000) The PPARs: from orphan receptors to drug discovery. J.Med.Chem. 43 527 PMID: 10691680

Fujimura et al (1998) Effects of troglitazone on the growth and differentiation of hematopoietic cell lines. Int.J.Oncol. 13 1263 PMID: 9824642


If you know of a relevant reference for Troglitazone, please let us know.

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Keywords: Troglitazone, Troglitazone supplier, Selective, PPARγ, PPARgamma, agonists, antidiabetic, agent, Peroxisome, Proliferator-activating, Receptors, Rezulin, Stem, Cell, Proliferation, 3114, Tocris Bioscience

3 Citations for Troglitazone

Citations are publications that use Tocris products. Selected citations for Troglitazone include:

Bisikirska et al (2016) Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression. Cancer Res 76 664 PMID: 26589882

Hegde et al (2015) Critical Role of Mast Cells and Peroxisome Proliferator-Activated Receptor γ in the Induction of Myeloid-Derived Suppressor Cells by Marijuana Cannabidiol In Vivo. J Immunol 194 5211 PMID: 25917103

Ross et al (2017) Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and sora. Cell Chem Biol 24 813 PMID: 28625738


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Literature in this Area

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