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Broad spectrum protein kinase C (PKC) inhibitor (IC50 values are 7, 7, 6, 10, 60 and 20000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ and PKCμ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Optimizes naïve human pluripotent stem cell growth and viability following naïve cell derivation from primed ESCs and iPSCs using naïve human stem cell medium (NHSM).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 442.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.52 mL||22.6 mL||45.2 mL|
|2.5 mM||0.9 mL||4.52 mL||9.04 mL|
|5 mM||0.45 mL||2.26 mL||4.52 mL|
|25 mM||0.09 mL||0.45 mL||0.9 mL|
References are publications that support the biological activity of the product.
Gschwendt et al (1996) Inhibition of protein kinase C μ by various inhibitors. Differentiation from protein kinase c isozymes. FEBS Lett. 392 77 PMID: 8772178
Peterman et al (2004) Go 6983 exerts cardioprotective effects in myocardial ischemic/reperfusion. J.Cardiovasc.Pharmacol. 43 645 PMID: 15071351
Young et al (2005) Go 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc.Drug Rev. 23 255 PMID: 16252018
Gafni et al (2013) Derivation of novel human ground state naive pluripotent stem cells. Nature 504 282 PMID: 24172903
If you know of a relevant reference for Go 6983, please let us know.
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Keywords: Go 6983, Go 6983 supplier, Broad, spectrum, PKC, inhibitors, inhibits, Protein, Kinases, C, Go6983, Goe6983, stem, cells, naive, Goe, 6983, Kinase, Stem, Cell, Proliferation, 2285, Tocris Bioscience
25 Citations for Go 6983
Citations are publications that use Tocris products. Selected citations for Go 6983 include:
Rostovskaya et al (2019) Capacitation of human naïve pluripotent stem cells for multi-lineage differentiation. Development 146 PMID: 30944104
Liu et al (2018) Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish. Transl Psychiatry 8 232 PMID: 30352990
Fang et al (2018) A distinct isoform of ZNF207 controls self-renewal and pluripotency of human embryonic stem cells. Nat Commun 9 4384 PMID: 30349051
Scarisbrick et al (2012) Kallikrein 6 is a novel molecular trigger of reactive astrogliosis. Front Cell Neurosci 393 355 PMID: 22505518
Garrett et al (2012) γ-protocadherins control cortical dendrite arborization by regulating the activity of a FAK/PKC/MARCKS signaling pathway. PLoS One 74 269 PMID: 22542181
Mclaurin and Weiner (2019) Multiple sources of signal amplification within the B-cell Ras/MAPK pathway. Mol Biol Cell 30 1610 PMID: 31042097
Baskin and Sayeski (2012) Angiotensin II mediates cell survival through upregulation and activation of the serum and glucocorticoid inducible kinase 1. BMC Complement Altern Med 24 435 PMID: 21963429
Messmer et al (2019) Transcriptional Heterogeneity in Naive and Primed Human Pluripotent Stem Cells at Single-Cell Resolution. Cell Rep 26 815 PMID: 30673604
Tuvikene et al (2016) AP-1 Transcription Factors Mediate BDNF-Positive Feedback Loop in Cortical Neurons. J Neurosci 36 1290 PMID: 26818516
Devinney et al (2015) Phrenic long-term facilitation requires PKCθ activity within phrenic motor neurons. Proc Natl Acad Sci U S A 35 8107 PMID: 26019328
Shakiba et al (2015) CD24 tracks divergent pluripotent states in mouse and human cells. J Biol Chem 6 7329 PMID: 26076835
Atwood et al (2013) GLI activation by atypical protein kinase C Ι/λ regulates the growth of basal cell carcinomas. J Neurosci 494 484 PMID: 23446420
Carriba (2017) CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons. Elife 6 PMID: 29111976
Schaffer et al (2018) PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5. Cell Rep 25 2470 PMID: 30485813
Pakpour et al (2013) Protein kinase C-dependent signaling controls the midgut epithelial barrier to malaria parasite infection in anopheline mosquitoes. PLoS One 8 e76535 PMID: 24146884
Vliet et al (2013) Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL). J Biol Chem 288 27519 PMID: 23918927
Rajendran et al (2013) Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency. J Biol Chem 288 24351 PMID: 23846691
Augustin et al (2017) Reduced ins. signaling maintains electrical transmission in a neural circuit in aging flies. PLoS Biol 15 e2001655 PMID: 28902870
Zhang et al (2017) Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med 214 2671 PMID: 28716882
Toda and Huganir (2015) Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38. Nat Commun 112 6712 PMID: 25964356
Li et al (2016) Progesterone receptor membrane component-1 regulates hepcidin biosynthesis. J Clin Invest 126 389 PMID: 26657863
Yi et al (2014) Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins. Neuron 289 30101 PMID: 25124035
Kuan et al (2014) Ets and GATA Transcription Factors Play a Critical Role in PMA-Mediated Repression of the ckβ Promoter via the Protein Kinase C Signaling Pathway. Biol Chem 9 e113485 PMID: 25490397
Cavaliere et al (2014) NMDA modulates oligodendrocyte differentiation of subventricular zone cells through PKC activation. Cell Signal 7 261 PMID: 24391542
Dutta et al (2011) Self-renewal versus lineage commitment of embryonic stem cells: protein kinase C signaling shifts the balance. Stem Cells 29 618 PMID: 21308862
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Human osteosarcoma cells were incubated with 20 μM Go 6983 for 30 min prior to treatment with 10 μM LPA to estimate COX-2 expression using Western blot analysis. Go 6983 abolished LPA-induced COX-2 expression.
Used for the culture of naive human pluripotent stem cells in t2iL+go media. Go 6983 used at 2µM concentration.
Literature in this Area
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