Y-27632 dihydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 1254 - Y-27632 dihydrochloride | C14H21N3O.2HCl | CAS No. 129830-38-2
Description: Selective p160ROCK inhibitor
Chemical Name: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (114)
Literature

Biological Activity

Selective p160ROCK inhibitor (Ki values are 0.14, 26, 25 and > 250 μM for p160ROCK, PKC, PKA and MLCK respectively). Also inhibits PRK2 (IC50 = 600 nM). Smooth muscle relaxant and orally active in vivo. Increases survival rate of human embryonic stem (hES) cells and iPSC-BMECs undergoing cryopreservation. Also optimizes naïve human pluripotent stem cell growth and viability following naïve cell derivation from primed ESCs and iPSCs using naïve human stem cell medium (NHSM).

Compound Libraries

Y-27632 dihydrochloride is also offered as part of the Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 320.26
Formula C14H21N3O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 129830-38-2
PubChem ID 14801906
InChI Key VJGZNBYDSDEOED-FJSYBICCSA-N
Smiles N[C@H](C)[C@@]1([H])CC[C@H]([C@](NC2=CC=NC=C2)=O)CC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
phosphate buffered saline 32.03 100
water 32.03 100

Preparing Stock Solutions

The following data is based on the product molecular weight 320.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.12 mL 15.61 mL 31.22 mL
5 mM 0.62 mL 3.12 mL 6.24 mL
10 mM 0.31 mL 1.56 mL 3.12 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Narumiya et al (2000) Use and properties of ROCK-specific inhibitor Y-27632. Methods Enzymol. 325 273 PMID: 11036610

Uehata et al (1997) Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase. Nature 389 990 PMID: 9353125

Ichikawa et al (2011) Freeze-thawing single human embryonic stem cells induce e-cadherin and actin filament network disruption via g13 signaling. Cryo Letters. 32 516 PMID: 22227712

Gafni et al (2013) Derivation of novel human ground state naive pluripotent stem cells. Nature 504 282 PMID: 24172903

Wilson et al (2016) Cryopreservation of brain endothelial cells derived from human induced pluripotent stem cells is enhanced by Rho-associated coiled coil-containing kinase inhibition. Tissue.Eng.Part C.Methods 22 1085 PMID: 27846787


If you know of a relevant reference for Y-27632 dihydrochloride, please let us know.

View Related Products by Product Action

View all Rho-Kinases Inhibitors

Keywords: Y-27632 dihydrochloride, supplier, Selective, p160ROCK, inhibitors, inhibits, Rho-Kinase, Rho-Associated, Coiled-Coil, Kinases, ROCK, ROK, stem, cells, organoids, Rho-kinases, Stem, Cell, Proliferation, Rho-kinases, Tocris Bioscience

114 Citations for Y-27632 dihydrochloride

Citations are publications that use Tocris products. Selected citations for Y-27632 dihydrochloride include:

Benedicto (2017) Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors. Nat Commun 8 15374 PMID: 28524846

Xi (2017) In Vivo Human Somitogenesis Guides Somite Development from hPSCs. Cell Rep 18 1573 PMID: 28178531

Hall (2017) Mesoderm-specific Stat3 deletion affects expression of Sox9 yielding Sox9-dependent phenotypes. PLoS Genet 13 e1006610 PMID: 28166224

Kotton et al (2017) Differentiation of human pluripotent stem cells into functional lung alveolar epithelial cells. Cell Stem Cell. 21 472 PMID: 28965766

Mou et al (2016) Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells Cell: Stem Cell 19 217 PMID: 27320041

Foulke-Abel et al (2016) Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology. Nat Commun 150 638 PMID: 26677983

Guye et al (2016) Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6. Sci Rep 7 10243 PMID: 26732624

Balcioglu et al (2016) Tumor-induced remote ECM network orientation steers angiogenesis. Development 6 22580 PMID: 26931404

Kellner et al (2016) Nogo-A controls structural plasticity at dendritic spines by rapidly modulating actin dynamics. Hippocampus 6 816 PMID: 26748478

Borgs et al (2016) Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects. Scientific Reports 6 33377 PMID: 27640816

Chal et al (2016) Generation of human muscle fibers and satellite-like cells from human pluripotent stem cells in vitro. Nat.Protoc. 11 1833 PMID: 27583644

Jardé et al (2016) Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids Nature Communications 7 13207 PMID: 27782124

Palpant et al (2016) Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using humanpluripotent stem cells. Nature Protocols 12 15 PMID: 27906170

Davies et al (2015) The Viral Mimetic Polyinosinic:Polycytidylic Acid Alters the Growth Characteristics of Small Intestinal and Colonic Crypt Cultures. PLoS One 10 e0138531 PMID: 26414184

Madsen et al (2015) Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis. EMBO Rep 16 1394 PMID: 26323721

Chen et al (2015) Variations in Glycogen Synthesis in Human Pluripotent Stem Cells with Altered Pluripotent States. PLoS One 10 e0142554 PMID: 26565809

Romero et al (2015) A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics. Elife 4 e07103 PMID: 26102527

Edri et al (2015) Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors. Nat Commun 6 6500 PMID: 25799239

Serra et al (2015) Simvastatin Increases Fibulin-2 Expression in Human Coronary Artery Smooth Muscle Cells via RhoA/Rho-Kinase Signaling Pathway Inhibition. PLoS One 10 e0133875 PMID: 26207907

Gjorevski et al (2015) Dynamic tensile forces drive collective cell migration through three-dimensional extracellular matrices. Sci Rep 5 11458 PMID: 26165921

Piao et al (2015) Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation. Cell Stem Cell 16 198 PMID: 25658373

Lee et al (2015) Machine learning plus optical flow: a simple and sensitive method to detect cardioactive drugs. Sci Rep 5 11817 PMID: 26139150

Pattabiraman et al (2015) RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork. Autophagy 185 496 PMID: 25499974

Lachmann et al (2015) Large-scale hematopoietic differentiation of human induced pluripotent stem cells provides granulocytes or macrophages for cell replacement therapies. Nat Commun 4 282 PMID: 25680479

Abraham et al (2015) A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis. Stem Cell Reports 6 7286 PMID: 26129894

Arbab et al (2015) Cloning-free CRISPR. Cell 5 908 PMID: 26527385

Ruprecht et al (2015) Cortical contractility triggers a stochastic switch to fast amoeboid cell motility. Int J Mol Sci 160 673 PMID: 25679761

Vergara et al (2015) Transgenic plants as low-cost platform for chemotherapeutic drugs screening. J Biol Chem 16 2174 PMID: 25608652

Lee et al (2015) Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling. Toxicol Sci 290 14740 PMID: 25911094

Tyson et al (2015) Duration of culture and sonic hedgehog signaling differentially specify PV versus SST cortical interneuron fates from embryonic stem cells. Stem Cells 142 1267 PMID: 25804737

Balcioglu et al (2015) The integrin expression profile modulates orientation and dynamics of force transmission at cell-matrix adhesions. Nat Biotechnol 128 1316 PMID: 25663698

Morizane et al (2015) Nephron organoids derived from human pluripotent stem cells model kidney development and injury. Nat Commun 33 1193 PMID: 26458176

Chaudhuri et al (2015) Substrate stress relaxation regulates cell spreading. Brain 6 6364 PMID: 25695512

Iovino et al (2015) Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations. Development 138 3345 PMID: 26220942

Jönsson et al (2015) Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor. Int J Nanomedicine 142 3166 PMID: 26395143

Tai et al (2015) Simvastatin enhances Rho/actin/cell rigidity pathway contributing to mesenchymal stem cells' osteogenic differentiation. Nat Commun 10 5881 PMID: 26451103

Sakaguchi et al (2015) Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue. Mol Vis 6 8896 PMID: 26573335

Su et al (2015) Phenotypes of trypsin- and collagenase-prepared bovine corneal endothelial cells in the presence of a selective Rho kinase inhibitor, Y-27632. PLoS Comput Biol 21 633 PMID: 26097378

Ziv et al (2015) Quantitative Live Imaging of Human Embryonic Stem Cell Derived Neural Rosettes Reveals Structure-Function Dynamics Coupled to Cortical Development. Stem Cell Reports 11 e1004453 PMID: 26473351

Fernandes et al (2015) Comparison of Human Embryonic Stem Cell-Derived Cardiomyocytes, Cardiovascular Progenitors, and Bone Marrow Mononuclear Cells for Cardiac Repair. Bone Res NULL PMID: 26607951

Maharam et al (2015) Rho/Rock signal transduction pathway is required for MSC tenogenic differentiation. Stem Cell Res Ther 3 15015 PMID: 26509098

Luzzani et al (2015) A therapy-grade protocol for differentiation of pluripotent stem cells into mesenchymal stem cells using platelet lysate as supplement. Int J Cancer 6 6 PMID: 25582222

Choi et al (2015) SDF-1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II. Stem Cell Reports 136 E219 PMID: 25137150

Höfner et al (2015) Defined conditions for the isolation and expansion of basal prostate progenitor cells of mouse and human origin. PLoS One 4 503 PMID: 25702639

Härmä et al (2015) Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development. Stem Cell Reports 10 e0126111 PMID: 25965345

Keimpema et al (2014) GABAergic terminals are a source of galanin to modulate cholinergic neuron development in the neonatal forebrain. Cereb Cortex 24 3277 PMID: 23897649

Moon et al (2014) Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis. Mucosal Immunol 7 818 PMID: 24220295

Orgaz et al (2014) Diverse matrix metalloproteinase functions regulate cancer amoeboid migration. Nat Commun 5 4255 PMID: 24963846

McNary et al (2014) Transforming growth factor β-induced superficial zone protein accumulation in the surface zone of articular cartilage is dependent on the cytoskeleton. Tissue Eng Part A 20 921 PMID: 24116978

Williams et al (2014) An in vivo role for Rho kinase activation in the tumour vascular disrupting activity of combretastatin A-4 3-O-phosphate. Br J Pharmacol 171 4902 PMID: 24930520

Huang et al (2014) Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol 32 84 PMID: 24291815

Sun et al (2014) Induction of entosis by epithelial cadherin expression. Cell Res 24 1288 PMID: 25342558

Liu and Chen (2014) Cryopreservation of human pluripotent stem cells in defined medium. Curr Protoc Stem Cell Biol 31 1C.17.1 PMID: 25366897

Luo et al (2014) Generation of GFP Reporter Human Induced Pluripotent Stem Cells Using AAVS1 Safe Harbor Transcription Activator-Like Effector Nuclease. Curr Protoc Stem Cell Biol 29 5A.7.1 PMID: 24838915

Mich et al (2014) Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain. Elife 3 e02669 PMID: 24843006

Pavlov et al (2014) Role of Rho GDP dissociation inhibitor α in control of epithelial sodium channel (ENaC)-mediated sodium reabsorption. J Biol Chem 289 28651 PMID: 25164814

Wile et al (2014) Molecular beacon-enabled purification of living cells by targeting cell type-specific mRNAs. Nat Protoc 9 2411 PMID: 25232937

Sun et al (2014) Competition between human cells by entosis. Cell Res 24 1299 PMID: 25342560

Shelton et al (2014) Derivation and expansion of PAX7-positive muscle progenitors from human and mouse embryonic stem cells. Stem Cell Reports 3 516 PMID: 25241748

Kameoka et al (2014) A high-throughput screen for teratogens using human pluripotent stem cells. J Biomol Screen 137 76 PMID: 24154490

Wrighton et al (2014) Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins. Circ Res 111 18126 PMID: 25422477

Aubdool et al (2014) TRPA1 is essential for the vascular response to environmental cold exposure. Korean J Physiol Pharmacol 5 5732 PMID: 25501034

Kirkeby et al (2013) Generating regionalized neuronal cells from pluripotency, a step-by-step protocol. Front Cell Neurosci 6 64 PMID: 23316134

Smith et al (2013) Interleukin-6 and oncostatin-M synergize with the PI3K/AKT pathway to promote aggressive prostate malignancy in mouse and human tissues. Mol Cancer Res 11 1159 PMID: 23867565

Calvo et al (2013) Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts. Nat Cell Biol 15 637 PMID: 23708000

Zeller et al (2013) The role of mechanical force and ROS in integrin-dependent signals. PLoS One 8 e64897 PMID: 23738008

Krajcovic et al (2013) mTOR regulates phagosome and entotic vacuole fission. Mol Biol Cell 24 3736 PMID: 24088573

Barthwal et al (2013) Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formation. PLoS One 8 e58054 PMID: 23536783

Hutchins et al (2013) Calcium release-dependent actin flow in the leading process mediates axophilic migration. J Cell Biochem 33 11361 PMID: 23843509

Lazzeroni et al (2013) A phenotypic screening assay for modulators of huntingtin-induced transcriptional dysregulation. Exp Neurol 18 984 PMID: 23562876

Pol et al (2013) Sox10-MCS5 enhancer dynamically tracks human oligodendrocyte progenitor fate. Stem Cell Res 247 694 PMID: 23507034

Crompton et al (2013) Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling. Nat Cell Biol 11 1206 PMID: 24013066

Lin et al (2013) Activation of β 1 but not β 3 integrin increases cell traction forces. J Neurosci 587 763 PMID: 23395612

Lu et al (2013) Generation of integration-free and region-specific neural progenitors from primate fibroblasts. Curr Biol 3 1580 PMID: 23643533

Hannan et al (2013) Inhibition of Rho-kinase improves erectile function, increases nitric oxide signaling and decreases penile apoptosis in a rat model of cavernous nerve injury. Am J Physiol Lung Cell Mol Physiol 189 1155 PMID: 23021998

Zhu and Nelson (2013) PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively. Cell 379 235 PMID: 23665174

Roller et al (2012) Synthetic lethal screening with small-molecule inhibitors provides a pathway to rational combination therapies for melanoma. Mol Cancer Ther 11 2505 PMID: 22962324

Harel et al (2012) ZFX controls the self-renewal of human embryonic stem cells. PLoS One 7 e42302 PMID: 22879936

Paige et al (2012) A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development. Cell 151 221 PMID: 22981225

Beers et al (2012) Passaging and colony expansion of human pluripotent stem cells by enzyme-free dissociation in chemically defined culture conditions. Nat Protoc 7 2029 PMID: 23099485

Guo et al (2012) Slug and Sox9 cooperatively determine the mammary stem cell state. J Cell Sci 148 1015 PMID: 22385965

Walker et al (2012) Intra-axonal translation of RhoA promotes axon growth inhibition by CSPG. J Cell Sci 32 14442 PMID: 23055514

Neely et al (2012) DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. Proc Natl Acad Sci U S A 3 482 PMID: 22860217

Sherwood et al (2011) Wnt signaling specifies and patterns intestinal endoderm. Mech Dev 128 387 PMID: 21854845

Kaur et al (2011) RhoJ/TCL regulates endothelial motility and tube formation and modulates actomyosin contractility and focal adhesion numbers. Arterioscler Thromb Vasc Biol 31 657 PMID: 21148427

Abreu-Blanco et al (2011) Cell wound repair in Drosophila occurs through three distinct phases of membrane and cytoskeletal remodeling. J Cell Biol 193 455 PMID: 21518790

Lee et al (2011) The Relaxing Effect of α-Defensin 1 on the Adrenergic Responses of Rat Bladder. Dev Biol 15 143 PMID: 21860592

Vallenius et al (2011) An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers. Integr Biol (Camb) 124 384 PMID: 21242312

Díez et al (2010) Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process. PLoS One 5 e14145 PMID: 21152444

Cao et al (2010) Cortical actin dynamics facilitate early-stage centrosome separation. J Pharmacol Exp Ther 20 770 PMID: 20409712

Gomez et al (2010) Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction. ACS Chem Neurosci 110 44 PMID: 20336666

Kim et al (2010) PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts. FEBS Lett 107 17206 PMID: 20858732

Gjorevski and Nelson (2010) Endogenous patterns of mechanical stress are required for branching morphogenesis. Stroke 2 424 PMID: 20717570

Giampieri et al (2009) Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility. Nat Commun 11 1287 PMID: 19838175

Desai et al (2009) Cell polarity triggered by cell-cell adhesion via E-cadherin. Br J Pharmacol 122 905 PMID: 19258396

Silva-Santos et al (2009) The Rho-A/Rho-kinase pathway is up-regulated but remains inhibited by cyclic guanosine monophosphate-dependent mechanisms during endotoxemia in small mesenteric arteries. J Biol Chem 37 1716 PMID: 19325475

Rodríguez-Vita et al (2008) Essential role of TGF-beta/Smad pathway on statin dependent vascular smooth muscle cell regulation. PLoS One 3 e3959 PMID: 19088845

Inan and Büyükafşar (2008) Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice. Am J Pathol 155 44 PMID: 18536751

Ruiz and Chen (2008) Emergence of patterned stem cell differentiation within multicellular structures. J Cell Sci 26 2921 PMID: 18703661

Bhadriraju et al (2007) Quantifying myosin light chain phosphorylation in single adherent cells with automated fluorescence microscopy. J Biol Chem 8 43 PMID: 17941977

Schaafsma et al (2007) Insulin induces airway smooth muscle contraction. Cell Rep 150 136 PMID: 17160007

Guillemot and Citi (2006) Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA. Mol Biol Cell 17 3569 PMID: 16723500

Wyckoff et al (2006) ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo. Curr Biol 16 1515 PMID: 16890527

Muñoz-García et al (2006) Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin. Proc Natl Acad Sci U S A 37 2044 PMID: 16809572

Hartmann et al (2005) CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells. Oncogene 24 4462 PMID: 15806155

Rodríguez-Vita et al (2005) Endothelin-1, via ETA receptor and independently of transforming growth factor-β, increases the connective tissue growth factor in vascular smooth muscle cells. Am J Physiol Cell Physiol 97 125 PMID: 15976312

Turner et al (2004) The activity of the plexin-A1 receptor is regulated by Rac. J Biol Chem 279 33199 PMID: 15187088

Schneider et al (2004) Signal transduction underlying carbachol-induced contraction of human urinary bladder. J Biol Chem 309 1148 PMID: 14769832

Surks et al (2003) Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA. J Biol Chem 278 51484 PMID: 14506264

Hippenstiel et al (2002) Rho protein inactivation induced apoptosis of cultured human endothelial cells. BMC Cell Biol 283 L830 PMID: 12225960

Huang et al (2002) Differential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substrate. Crit Care Med 277 27265 PMID: 12011056

Jung et al (2002) Interaction of cofilin with triose-phosphate isomerase contributes glycolytic fuel for Na,K-ATPase via Rho-mediated signaling pathway. Br J Pharmacol 277 48931 PMID: 12359716

An et al (2002) Stiffness changes in cultured airway smooth muscle cells. Gastroenterology 283 C792 PMID: 12176736

Vinson et al (2001) Myelin-associated glycoprotein interacts with ganglioside GT1b. A mechanism for neurite outgrowth inhibition. J Urol 276 20280 PMID: 11279053


Do you know of a great paper that uses Y-27632 dihydrochloride from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for Y-27632 dihydrochloride

Protocols

TODO: Add Protocols