Yhhu 3792

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Notch signaling pathway activator; enhances the self-renewal capability of NSCs; active in vivo
Chemical Name: 5-(3-Methoxyphenoxy)-N2-[4-(1-methylethyl)phenyl]-2,4-quinazolinediamine hydrochloride
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for Yhhu 3792

Yhhu 3792 is a notch signaling pathway activator; enhances the self-renewal capability of neural stem cells (NSCs) via Notch signaling pathway activation in vitro and in vivo. Promotes the expression of Notch target genes, Hes3 and Hes5. Expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) after chronic administration in mice. Increases the spatial and episodic memory in mice.

Compound Libraries for Yhhu 3792

Yhhu 3792 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Yhhu 3792

M. Wt 436.93
Formula C24H24N4O2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2624336-93-0
Smiles COC1=CC=CC(OC2=CC=CC3=C2C(N)=NC(NC4=CC=C(C(C)C)C=C4)=N3)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Yhhu 3792

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 43.69 100

Preparing Stock Solutions for Yhhu 3792

The following data is based on the product molecular weight 436.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.44 mL 22.89 mL
5 mM 0.46 mL 2.29 mL 4.58 mL
10 mM 0.23 mL 1.14 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Yhhu 3792

Certificate of Analysis / Product Datasheet
Select another batch:

References for Yhhu 3792

References are publications that support the biological activity of the product.

Lu (2018) A novel 2-phenylamino-quinazoline-based compound expands the neural stem cell pool and promotes the hippocampal neurogenesis and the cognitive ability of adult mice. Stem Cells 36 1273 PMID: 29726088

If you know of a relevant reference for Yhhu 3792, please let us know.

View Related Products by Product Action

View all Other Notch Signaling Activators

Keywords: Yhhu 3792, Yhhu 3792 supplier, Yhhu3792, Notch, signaling, pathway, activators, activates, neural, stem, cells, NSCs, memory, in, vivo, Other, Signaling, Stem, Cell, Proliferation, 6599, Tocris Bioscience

1 Citation for Yhhu 3792

Citations are publications that use Tocris products. Selected citations for Yhhu 3792 include:

Srustidhar et al (2022) Interleukin-10 regulates goblet cell numbers through Notch signaling in the developing zebrafish intestine. Mucosal Immunol 15 940-951 PMID: 35840681

Do you know of a great paper that uses Yhhu 3792 from Tocris? Please let us know.

Reviews for Yhhu 3792

There are currently no reviews for this product. Be the first to review Yhhu 3792 and earn rewards!

Have you used Yhhu 3792?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review