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Description: Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogeneisis
Chemical Name: (3S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2H-1-benzopyran-3-carboxamide dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity
Highly potent and selective ROCK2 inhibitor (IC50 values are 1 and 52 pM at ROCK2 and ROCK1, respectively). Exhibits selectivity over a range of related kinases including PKA, AKT1 and MRCK (IC50 values are >20000, >20000 and 150 nM respectively). Improves cell survival after cryogenesis. Also promotes survival of stem cells in culture.
Technical Data
| M. Wt | 509.43 |
| Formula | C24H28N4O4.2HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| InChI Key | ROFMCPHQNWGXGE-SFHVURJKSA-N |
| Smiles | COC1=CC=C2OC[C@@H](C(NC3=C(C=C(C4=CNN=C4)C=C3)OCCN(C)C)=O)CC2=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.94 | 100 | |
| water | 2.55 | 5 |
Preparing Stock Solutions
The following data is based on the product molecular weight 509.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.96 mL | 9.81 mL | 19.63 mL |
| 5 mM | 0.39 mL | 1.96 mL | 3.93 mL |
| 10 mM | 0.2 mL | 0.98 mL | 1.96 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.39 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Chen et al (2011) Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors. Med.Chem.Commun. 2 73
Chen et al (2019) A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells. BioRxiv - Paper not yet peer reviewed.
If you know of a relevant reference for Chroman 1, please let us know.
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Citations for Chroman 1
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