Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewHighly potent and selective ROCK2 inhibitor (IC50 values are 1 and 52 pM at ROCK2 and ROCK1, respectively). Exhibits selectivity over a range of related kinases including PKA, AKT1 and MRCK (IC50 values are >20000, >20000 and 150 nM respectively). Improves cell survival after cryogenesis. Also promotes survival of stem cells in culture.
Chroman 1 is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
M. Wt | 509.43 |
Formula | C24H28N4O4.2HCl |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
InChI Key | ROFMCPHQNWGXGE-SFHVURJKSA-N |
Smiles | COC1=CC=C2OC[C@@H](C(NC3=C(C=C(C4=CNN=C4)C=C3)OCCN(C)C)=O)CC2=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 50.94 | 100 | |
water | 2.55 | 5 |
The following data is based on the product molecular weight 509.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.96 mL | 9.81 mL | 19.63 mL |
5 mM | 0.39 mL | 1.96 mL | 3.93 mL |
10 mM | 0.2 mL | 0.98 mL | 1.96 mL |
50 mM | 0.04 mL | 0.2 mL | 0.39 mL |
References are publications that support the biological activity of the product.
Chen et al (2011) Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors. Med.Chem.Commun. 2 73
Chen et al (2019) A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells. BioRxiv - Paper not yet peer reviewed.
If you know of a relevant reference for Chroman 1, please let us know.
Keywords: Chroman 1, Chroman 1 supplier, Selective, p160, ROCK, inhibitors, inhibits, Rho-Kinase, Rho-Associated, Coiled-Coil, Kinases, ROK, stem, cells, organoids, induced, pluripotent, ROCKI, ROCK1, ROCKII, ROCK2, reprogramming, cryopreservation, differentiation, cell, freezing, media, cryogenesis, self, renewed, Rho-kinases, Stem, Cell, Proliferation, Reprogramming, Organoids, Neural, Cells, 7163, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for Chroman 1. Do you know of a great paper that uses Chroman 1 from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review Chroman 1 and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.