AMD 3100 octahydrochloride

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Cat.No. 3299 - AMD 3100 octahydrochloride | C28H54N8.8HCl | CAS No. 155148-31-5
Description: Highly selective CXCR4 antagonist
Alternative Names: JM 3100, Plerixafor
Chemical Name: 1,1'-[1,4-Phenylenebis-(methylene)]-bis-(1,4,8,11-tetraazacyclotetradecane) octahydrochloride
Citations (16)
Literature (3)

Biological Activity

Highly selective CXCR4 chemokine receptor antagonist (IC50 values are 0.02 - 0.13 and > 25 μM for CXCR4 and all other chemokine receptors respectively). Switches inflammatory responses from Th2 to Th1 type and reduces airway hyperresponsiveness in a mouse model of asthma. Potently inhibits HIV-1 and HIV-2 replication in vitro (EC50 = 4 - 35 nM) and mobilizes hematopoietic stem cells in vivo. Attenuates cocaine place preference and locomotor stimulation in rats. Attenuates microglial activation neurological function after ischemic stroke in mice. Inhibits tumor cell migration and proliferation in vitro and in vivo in a range of cancers.

Technical Data

M. Wt 794.48
Formula C28H54N8.8HCl
Storage Desiccate at -20°C
CAS Number 155148-31-5
PubChem ID 65014

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 79.45 100

Preparing Stock Solutions

The following data is based on the product molecular weight 794.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.26 mL 6.29 mL 12.59 mL
5 mM 0.25 mL 1.26 mL 2.52 mL
10 mM 0.13 mL 0.63 mL 1.26 mL
50 mM 0.03 mL 0.13 mL 0.25 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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16 Citations for AMD 3100 octahydrochloride

Citations are publications that use Tocris products. Selected citations for AMD 3100 octahydrochloride include:

Beck et al (2014) CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow. J Exp Med 211 2567 PMID: 25403444

Mycko et al (2014) Brain glycolipids suppress T helper cells and inhibit autoimmune demyelination. J Neurosci 34 8646 PMID: 24948818

Farkas et al (2014) CXCR4 inhibition ameliorates severe obliterative pulmonary hypertension and accumulation of C-kit+ cells in rats. PLoS One 9 e89810 PMID: 24587052

Ray et al (2011) Noninvasive imaging reveals inhibition of ovarian cancer by targeting CXCL12-CXCR4. Am J Pathol 13 1152 PMID: 22241961

Laschke et al (2011) Endothelial progenitor cells contribute to the vascularization of endometriotic lesions. Development 178 442 PMID: 21224081

Kouzoukas et al (2015) Macrophage Migration Inhibitory Factor Mediates PAR-Induced Bladder Pain. PLoS One 10 e0127628 PMID: 26020638

Griffiths (2018) Anti-fibrotic effects of CXCR4-targeting i-body AD-114 in preclinical models of pulmonary fibrosis. Sci Rep 8 3212 PMID: 29453386

Sakitani (2017) CXCR4-expressing Mist1 + progenitors in the gastric antrum contribute to gastric cancer development. Oncotarget 8 111012 PMID: 29340033

Arjunan et al (2018) Oral Pathobiont Activates Anti-Apoptotic Pathway, Promoting both Immune Suppression and Oncogenic Cell Proliferation. Sci Rep 8 16607 PMID: 30413788

Ahmed et al (2017) Agarose Spot as a Comparative Method for in situ Analysis of Simultaneous Chemotactic Responses to Multiple Chemokines. Sci Rep 7 1075 PMID: 28432337

He et al (2018) Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues. Immunity 49 1175 PMID: 30527911

Casanova-Acebes et al (2013) Rhythmic modulation of the hematopoietic niche through neutrophil clearance. Cell 153 1025 PMID: 23706740

Chu et al (2015) CXCR4 Antagonism Attenuates the Development of Diabetic Cardiac Fibrosis. Neoplasia 10 e0133616 PMID: 26214690

Cavnar et al (2015) Modeling selective elimination of quiescent cancer cells from bone marrow. Cell 17 625 PMID: 26408255

Zhang et al (2013) Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Neoplasia 154 1060 PMID: 23993096

Chigaev et al (2011) Discovery of very late antigen-4 (VLA-4, alpha4beta1 integrin) allosteric antagonists. J Biol Chem 286 5455 PMID: 21131351

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