Reprogramming

More Information »Reprogramming refers to the regression of a specialized cell to a simpler state, resulting in cells with stem-like properties, or the direct reprogramming of one specialized cell type into another. The process of cells regressing to a stem-like state occurs naturally, mostly for repair and regeneration in aged or damaged tissues.

Reprogramming Products

 
Cat.No.
Product Name / Activity
6044 AS 8351
Induces reprogramming of fibroblasts into functional cardiomyocytes
4055 L-Ascorbic acid
Enhances the generation of iPSCs; increases reprogramming efficiency
3842 5-Azacytidine
DNA methyltransferase inhibitor. Improves reprogramming efficiency
1544 (±)-Bay K 8644
Ca2+ channel activator (L-type); aids generation of iPSCs from MEFs
3364 BIX 01294
GLP and G9a inhibitor; potentiates induction of iPSCs
4423 CHIR 99021
Highly selective GSK-3 inhibitor; enables reprogramming of mouse embryonic fibroblasts into iPS cells
4489 DBZ
Notch signaling pathway inhibitor; stimulates formation of iPSCs
4703 3-Deazaneplanocin A hydrochloride
Histone methyltransferase inhibitor; enhances Oct4 expression in chemically-induced pluripotent stem cells
1398 Kenpaullone
Promotes generation of iPSCs from somatic cells; also potent cdk inhibitor and GSK-3 inhibitor
3656 Neurodazine
Induces neurogenesis in mature skeletal muscle cells
5639 O4I1
Oct3/4 inducer
5664 O4I2
Oct3/4 inducer; induces expression of pluripotent-associated genes
4887 OAC-1
Oct4 activator; enhances iPSC reprogramming efficiency
4192 PD 0325901
Selective inhibitor of MEK1/2; enhances generation of iPSCs
2653 Pifithrin-μ
Inhibitor of p53-mitochondrial binding
3742 RepSox
Selective TGF-βRI inhibitor; enhances reprogramming efficiency
3295 RG 108
Non-nucleoside DNA methyltransferase inhibitor; enhances efficiency of iPSC generation
4297 SMER 28
Promotes reprogramming of fibroblasts to neural stem-like cells
3845 Thiazovivin
Improves the efficiency of fibroblast reprogramming and induction of iPSCs
3852 Tranylcypromine hydrochloride
Irreversible inhibitor of LSD1; enables reprogramming of mouse embryonic fibroblasts into iPS cells
1406 Trichostatin A
Potent histone deacetylase inhibitor; induces accelerated dedifferentiation of primordial germ cells
0761 TTNPB
Retinoic acid analog; enhances efficiency of reprogramming in CiPSCs
2815 Valproic acid, sodium salt
Histone deacetylase inhibitor; enables induction of pluripotent stem cells from somatic cells
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Stem Cell Toolbox

80 Stem Cell modulators supplied pre-dissolved in DMSO

Tocriscreen Stem Cell  Toolbox

Includes many of the latest compounds available for stem cell research. Covers compounds for stem cell differentiation, signaling and reprogramming.

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Stem Cells Review

Written by K. Clarke et al

Stem Cells Scientific Review

Our Stem Cells review gives an overview of the use of small molecules in the control of stem cell growth & differentiation and somatic cell reprogramming. Request copy or view PDF today.

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