(S)-(+)-Dimethindene maleate

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Cat.No. 1425 - (S)-(+)-Dimethindene maleate | C20H24N2.C4H4O4 | CAS No. 136152-65-3
Description: M2-selective antagonist
Chemical Name: N,N-Dimethyl-3-[(1S)-1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine maleate
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Enantiomer that is a subtype-selective M2 muscarinic receptor antagonist (pKi values are 7.08, 7.78, 6.70 and 7.00 for M1, M2, M3 and M4 receptors respectively). Also H1 histamine receptor antagonist (pKi = 7.48). Allows formation of extended pluripotent stem (EPS) cells in combination with CHIR 99021 (Cat.No. 4423), minocycline hydrochloride (Cat.No. 3268) and human leukemia inhibitory factor.

Technical Data

M. Wt 408.5
Formula C20H24N2.C4H4O4
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 136152-65-3
PubChem ID 56972160
InChI Key SWECWXGUJQLXJF-HFNHQGOYSA-N
Smiles C[C@H](C3=NC=CC=C3)C2=C(CCN(C)C)CC1=CC=CC=C12.OC(=O)\C=C/C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 29.24 100 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 408.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.24 mL 24.48 mL
5 mM 0.49 mL 2.45 mL 4.9 mL
10 mM 0.24 mL 1.22 mL 2.45 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Lambrecht et al (1999) Neuronal soma-dendritic and prejunctional M1-M4 receptors in gastrointestinal and genitourinary smooth muscle. Life Sci. 64 403 PMID: 10069503

Pfaff et al (1995) The (S)-(+)-enantiomer of dimethindene: a novel M2-selective muscarinic receptor antagonist. Eur.J.Pharmacol. 286 229 PMID: 8608784

Yang et al (2017) Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency. Cell. 169 243 PMID: 28388409


If you know of a relevant reference for (S)-(+)-Dimethindene maleate, please let us know.

View Related Products by Product Action

View all M2 Receptor Antagonists

Keywords: (S)-(+)-Dimethindene maleate, (S)-(+)-Dimethindene maleate supplier, H1, antagonists, M2, muscarinic, Receptors, Histamine, Acetylcholine, ACh, histaminergic, Reprogramming, 1425, Tocris Bioscience

2 Citations for (S)-(+)-Dimethindene maleate

Citations are publications that use Tocris products. Selected citations for (S)-(+)-Dimethindene maleate include:

Yang et al (2017) Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency. Cell. 169 243 PMID: 28388409

Matsumoto et al (2010) Differential roles of M2 and M3 muscarinic receptor subtypes in modulation of bladder afferent activity in rats. Urology 75 862 PMID: 20156651


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Literature in this Area

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