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Enantiomer that is a subtype-selective M2 muscarinic receptor antagonist (pKi values are 7.08, 7.78, 6.70 and 7.00 for M1, M2, M3 and M4 receptors respectively). Also H1 histamine receptor antagonist (pKi = 7.48). Allows formation of extended pluripotent stem (EPS) cells in combination with CHIR 99021 (Cat.No. 4423), minocycline hydrochloride (Cat.No. 3268) and human leukemia inhibitory factor.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||29.24||100 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 408.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.45 mL||12.24 mL||24.48 mL|
|5 mM||0.49 mL||2.45 mL||4.9 mL|
|10 mM||0.24 mL||1.22 mL||2.45 mL|
|50 mM||0.05 mL||0.24 mL||0.49 mL|
References are publications that support the biological activity of the product.
Lambrecht et al (1999) Neuronal soma-dendritic and prejunctional M1-M4 receptors in gastrointestinal and genitourinary smooth muscle. Life Sci. 64 403 PMID: 10069503
Pfaff et al (1995) The (S)-(+)-enantiomer of dimethindene: a novel M2-selective muscarinic receptor antagonist. Eur.J.Pharmacol. 286 229 PMID: 8608784
Yang et al (2017) Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency. Cell. 169 243 PMID: 28388409
If you know of a relevant reference for (S)-(+)-Dimethindene maleate, please let us know.
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Keywords: (S)-(+)-Dimethindene maleate, (S)-(+)-Dimethindene maleate supplier, H1, antagonists, M2, muscarinic, Receptors, Histamine, Acetylcholine, ACh, histaminergic, Reprogramming, 1425, Tocris Bioscience
6 Citations for (S)-(+)-Dimethindene maleate
Citations are publications that use Tocris products. Selected citations for (S)-(+)-Dimethindene maleate include:
Xu et al (2019) Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system. Stem Cell Res Ther 10 193 PMID: 31248457
Du et al (2019) Efficient derivation of extended pluripotent stem cells from NOD-scid Il2rg-/- mice. Protein Cell 10 31 PMID: 29948854
Li et al (2018) Rapid generation of gene-targeted EPS-derived mouse models through tetraploid complementation. Protein Cell PMID: 29948855
Matsumoto et al (2010) Differential roles of M2 and M3 muscarinic receptor subtypes in modulation of bladder afferent activity in rats. Urology 75 862 PMID: 20156651
Yang et al (2017) Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency. Cell 169 243 PMID: 28388409
Li et al (2019) Generation of blastocyst-like structures from mouse embryonic and adult cell cultures. Cell 179 687 PMID: 31626770
Do you know of a great paper that uses (S)-(+)-Dimethindene maleate from Tocris? Please let us know.
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Protocols for (S)-(+)-Dimethindene maleate
The following protocol features additional information for the use of (S)-(+)-Dimethindene maleate (Cat. No. 1425).
Literature in this Area
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*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.