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SAG dihydrochloride

Cat. No. 6390 1 Review Submit a Review Datasheet / COA / SDS
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Cat.No. 6390 - SAG dihydrochloride | C28H28ClN3OS.2HCl
Description: Dihydrochloride salt of SAG; Smo receptor agonist
Chemical Name: 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Dihydrochloride salt of SAG; a potent Smoothened (Smo) receptor agonist.

Technical Data

M. Wt 562.98
Formula C28H28ClN3OS.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 71433770
InChI Key IYXUQUYRWPGIQL-UHFFFAOYSA-N
Smiles ClC1=C(C(N([C@H]2CC[C@H](NC)CC2)CC3=CC=CC(C4=CC=NC=C4)=C3)=O)SC5=CC=CC=C51

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 56.3 100
DMSO 56.3 100

Preparing Stock Solutions

The following data is based on the product molecular weight 562.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.78 mL 8.88 mL 17.76 mL
5 mM 0.36 mL 1.78 mL 3.55 mL
10 mM 0.18 mL 0.89 mL 1.78 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

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Citations for SAG dihydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for SAG dihydrochloride. Do you know of a great paper that uses SAG dihydrochloride from Tocris? Please let us know.

Reviews for SAG dihydrochloride

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MUCH better than the others!!.
By Anonymous on 08/28/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: stem cells

This SAG performs the BEST for stem cell differentiation to neuronal lineages. Other brands do not work. We use it at 1uM after dual SMAD inhibition.

Literature in this Area

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