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Submit ReviewSAG dihydrochloride
Description: Dihydrochloride salt of SAG; Smo receptor agonist
Chemical Name: 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide dihydrochloride
Purity: ≥99% (HPLC)
Biological Activity
Dihydrochloride salt of SAG; a potent Smoothened (Smo) receptor agonist.
Technical Data
| M. Wt | 562.98 |
| Formula | C28H28ClN3OS.2HCl |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| PubChem ID | 71433770 |
| InChI Key | IYXUQUYRWPGIQL-UHFFFAOYSA-N |
| Smiles | ClC1=C(C(N([C@H]2CC[C@H](NC)CC2)CC3=CC=CC(C4=CC=NC=C4)=C3)=O)SC5=CC=CC=C51 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 56.3 | 100 | |
| DMSO | 56.3 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 562.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.78 mL | 8.88 mL | 17.76 mL |
| 5 mM | 0.36 mL | 1.78 mL | 3.55 mL |
| 10 mM | 0.18 mL | 0.89 mL | 1.78 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
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