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Submit ReviewDihydrochloride salt of SAG; a potent Smoothened (Smo) receptor agonist.
M. Wt | 562.98 |
Formula | C28H28ClN3OS.2HCl |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
PubChem ID | 71433770 |
InChI Key | IYXUQUYRWPGIQL-UHFFFAOYSA-N |
Smiles | ClC1=C(C(N([C@H]2CC[C@H](NC)CC2)CC3=CC=CC(C4=CC=NC=C4)=C3)=O)SC5=CC=CC=C51 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
water | 56.3 | 100 | |
DMSO | 56.3 | 100 |
The following data is based on the product molecular weight 562.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.78 mL | 8.88 mL | 17.76 mL |
5 mM | 0.36 mL | 1.78 mL | 3.55 mL |
10 mM | 0.18 mL | 0.89 mL | 1.78 mL |
50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
References are publications that support the biological activity of the product.
If you know of a relevant reference for SAG dihydrochloride, please let us know.
Keywords: SAG dihydrochloride, SAG dihydrochloride supplier, Potent, Smoothened, Smo, receptors, agonists, activates, Hedgehog, signaling, pathway, activator, enhancers, neuronal, differentiation, iPSCs, inducible, pluripotent, stem, cells, dopaminergic, neurons, neurones, 912545-86-9, Receptors, Neural, Stem, Cells, 6390, Tocris Bioscience
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Average Rating: 5 (Based on 1 Review.)
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This SAG performs the BEST for stem cell differentiation to neuronal lineages. Other brands do not work. We use it at 1uM after dual SMAD inhibition.