Valproic acid, sodium salt

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Cat.No. 2815 - Valproic acid, sodium salt | C8H15NaO2 | CAS No. 1069-66-5
Description: Histone deacetylase inhibitor
Alternative Names: VPA, Sodium Valproate
Chemical Name: Sodium 2-propylpentanoate
Datasheet
Citations (3)
Reviews
Protocols (1)
Literature

Biological Activity

Histone deacetylase inhibitor (IC50 = 400 μM) that exhibits anticancer, anti-inflammatory and neuroprotective effects. Displays anticonvulsive activity via an increase in GABA levels and decreases Aβ production in animal models of Alzheimer's disease. Also attenuates NMDA-mediated excitation, blocks voltage-gated Na+ channels and modulates firing of neurons. Enables induction of pluripotent stem cells from somatic cells by Oct4 and Sox2. Can induce autophagy by inhibiting inositol synthesis.

Compound Libraries

Valproic acid, sodium salt is also offered as part of the Tocriscreen Plus, Tocriscreen Epigenetics Toolbox and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 166.19
Formula C8H15NaO2
Storage Desiccate at RT
CAS Number 1069-66-5
PubChem ID 16760703
InChI Key AEQFSUDEHCCHBT-UHFFFAOYSA-M
Smiles [Na+].CCCC(CCC)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 16.62 100
DMSO 8.31 50

Preparing Stock Solutions

The following data is based on the product molecular weight 166.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.02 mL 30.09 mL 60.17 mL
5 mM 1.2 mL 6.02 mL 12.03 mL
10 mM 0.6 mL 3.01 mL 6.02 mL
50 mM 0.12 mL 0.6 mL 1.2 mL

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References

References are publications that support the biological activity of the product.

Phiel et al (2001) Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J.Biol.Chem. 276 36734 PMID: 11473107

Kostrouchova et al (2007) Valproic acid, a molecular lead to multiple regulatory pathways. Folia Biologica 53 37 PMID: 17448293

Kim et al (2007) Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J.Pharmacol.Exp.Ther. 321 892 PMID: 17371805

Qing et al (2008) Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioural defects in Alzheimer's disease mouse models. J.Exp.Med. 205 2781 PMID: 18955571

Huangfu et al (2008) Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat.Biotechnol. 26 1269 PMID: 18849973


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View Related Products by Product Action

View all Non-selective Histone Deacetylase Inhibitors

Keywords: Valproic acid, sodium salt, Valproic acid, sodium salt supplier, Histone, deacetylases, inhibitors, inhibits, Increases, GABA, levels, anticonvulsant, HDAC, GABAA, GABAC, Receptors, GABAB, stem, cells, epigenetics, VPA, Sodium, Valproate, Miscellaneous, Reprogramming, Autophagy, Voltage-gated, Channels, Non-selective, HDACs, Non-Selective, 2815, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Valproate (Valproic acid), which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

3 Citations for Valproic acid, sodium salt

Citations are publications that use Tocris products. Selected citations for Valproic acid, sodium salt include:

Caires-Júnior (2018) Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells. Nat Commun 9 475 PMID: 29396410

Chen et al (2015) Overexpression of the type 1 adenylyl cyclase in the forebrain leads to deficits of behavioral inhibition. Nat Commun 35 339 PMID: 25568126

Wang et al (2014) The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer. Cancer Biol Ther 15 1198 PMID: 24919179


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Protocols for Valproic acid, sodium salt

The following protocol features additional information for the use of Valproic acid, sodium salt (Cat. No. 2815).

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

  • Bromodomains
  • DNA Methyltransferases
  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases
Rheumatoid Arthritis

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.