Valproic acid, sodium salt

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Cat.No. 2815 - Valproic acid, sodium salt | C8H15NaO2 | CAS No. 1069-66-5
Description: Histone deacetylase inhibitor
Alternative Names: VPA, Sodium Valproate
Chemical Name: Sodium 2-propylpentanoate
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Histone deacetylase inhibitor (IC50 = 400 μM) that exhibits anticancer, anti-inflammatory and neuroprotective effects. Displays anticonvulsive activity via an increase in GABA levels and decreases Aβ production in animal models of Alzheimer's disease. Also attenuates NMDA-mediated excitation, blocks voltage-gated Na+ channels and modulates firing of neurons. Enables induction of pluripotent stem cells from somatic cells by Oct4 and Sox2. Can induce autophagy by inhibiting inositol synthesis.

Compound Libraries

Valproic acid, sodium salt is also offered as part of the Tocriscreen Plus, Tocriscreen Epigenetics Toolbox and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 166.19
Formula C8H15NaO2
Storage Desiccate at RT
CAS Number 1069-66-5
PubChem ID 16760703
InChI Key AEQFSUDEHCCHBT-UHFFFAOYSA-M
Smiles [Na+].CCCC(CCC)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 16.62 100
DMSO 8.31 50

Preparing Stock Solutions

The following data is based on the product molecular weight 166.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.02 mL 30.09 mL 60.17 mL
5 mM 1.2 mL 6.02 mL 12.03 mL
10 mM 0.6 mL 3.01 mL 6.02 mL
50 mM 0.12 mL 0.6 mL 1.2 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Phiel et al (2001) Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J.Biol.Chem. 276 36734 PMID: 11473107

Kostrouchova et al (2007) Valproic acid, a molecular lead to multiple regulatory pathways. Folia Biologica 53 37 PMID: 17448293

Kim et al (2007) Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J.Pharmacol.Exp.Ther. 321 892 PMID: 17371805

Qing et al (2008) Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioural defects in Alzheimer's disease mouse models. J.Exp.Med. 205 2781 PMID: 18955571

Huangfu et al (2008) Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat.Biotechnol. 26 1269 PMID: 18849973


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View Related Products by Product Action

View all Class I and II Histone Deacetylase Inhibitors

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3 Citations for Valproic acid, sodium salt

Citations are publications that use Tocris products. Selected citations for Valproic acid, sodium salt include:

Caires-Júnior (2018) Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells. Nat Commun 9 475 PMID: 29396410

Chen et al (2015) Overexpression of the type 1 adenylyl cyclase in the forebrain leads to deficits of behavioral inhibition. Nat Commun 35 339 PMID: 25568126

Wang et al (2014) The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer. Cancer Biol Ther 15 1198 PMID: 24919179


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Literature in this Area

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