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Biological Activity for DBZ
DBZ is an inhibitor of γ-secretase aspartyl protease. DBZ blocks amyloid precursor protein-like (APPL) and Notch cleavage (IC50 values are 2.6 nM and 1.7-2.9 nM, respectively). By inhibiting Notch and the Notch pathway, DBZ improves efficiency of iPSC generation and production of iPSCs from mouse and human keratinocytes without KLF4 and CMYC. In an animal model of Alzheimer's disease, DBZ inhibits the cleavage of amyloid precursor protein into Aβ40. DBZ promotes cochlear supporting cell proliferation and hair cell mitotic regeneration in neonatal mice. DBZ in combination with iDOT1L enables maintenance of human naïve-state pluripotency in non-hypoxic conditions.
DBZ synthesized to Ancillary Material Grade also available.
Compound Libraries for DBZ
Technical Data for DBZ
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DBZ
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for DBZ
The following data is based on the product molecular weight 463.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.16 mL||10.79 mL||21.58 mL|
|5 mM||0.43 mL||2.16 mL||4.32 mL|
|10 mM||0.22 mL||1.08 mL||2.16 mL|
|50 mM||0.04 mL||0.22 mL||0.43 mL|
References for DBZ
References are publications that support the biological activity of the product.
Groth et al (2010) Pharmacological analysis of Drosophila melanogaster γ-secretase with respect to differential proteolysis of Notch and APP. Mol.Pharmacol. 77 567 PMID: 20064975
van Es et al (2005) Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 435 959 PMID: 15959515
Ichida et al (2014) Notch inhibition allows oncogene-independent generation of iPS cells. Nat.Chem.Biol. 10 632 PMID: 24952596
Wu et al (2020) Dibenzazepine promotes cochlear supporting cell proliferation and hair cell regeneration in neonatal mice. Cell Prolif. 53 e12872 PMID: 32677724
Isono et al (2020) The combination of dibenzazepine and a DOT1L inhibitor enables a stable maintenance of human naïve-state pluripotency in non-hypoxic conditions. Regen.Ther. 15 161 PMID: 33426214
If you know of a relevant reference for DBZ, please let us know.
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Keywords: DBZ, DBZ supplier, Notch, inhibitors, inhibits, gamma, γ, g-secretases, signaling, signalling, pathways, gamma-secretase, amyloid, stem, cells, iPSCs, induced, pluripotent, reprogramming, dedifferentiation, YO01027, YO-01027, alzheimers, APP, Ab, Abeta, Dibenzazepine, Gamma-Secretase, Stem, Cell, Reprogramming, Organoids, 4489, Tocris Bioscience
11 Citations for DBZ
Citations are publications that use Tocris products. Selected citations for DBZ include:
Yung et al (2019) Sufu- And Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals. Nat.Commun. 10 4647 PMID: 31604927
Santos et al (2019) Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity. Nat.Commun. 10 4407 PMID: 31562298
Marshall et al (2018) Analysis of the Intrinsic Self-Organising Properties of Mesenchymal Stromal Cells in Three-Dimensional Co-Culture Models with Endothelial Cells. Bioengineering (Basel) 5 PMID: 30373192
Bi et al (2016) Stage-specific effects of Notch activation during skeletal myogenesis. Elife 5 PMID: 27644105
Shah et al (2013) The role of Notch and γ-secretase inhibition in an ovarian cancer model. J Reprod Dev 33 801 PMID: 23482747
Page et al (2019) Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis. Cell Rep 27 3139 PMID: 31189101
Bi et al (2014) Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity. Nat Med 20 911 PMID: 25038826
Khan et al (2018) The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer. J Clin Invest 128 1326 PMID: 29346117
Chen et al (2018) Cancer-associated fibroblasts suppress SOX2-induced dysplasia in a lung squamous cancer coculture. Proc Natl Acad Sci U S A 115 E11671 PMID: 30487219
Ihara et al (2016) TGF-β Signaling in Dendritic Cells Governs Colonic Homeostasis by Controlling Epithelial Differentiation and the Luminal Microbiota. J Immunol 196 4603 PMID: 27183608
Bi et al (2016) Notch activation drives adipocyte dedifferentiation and tumorigenic transformation in mice. J Exp Med 213 2019 PMID: 27573812
Do you know of a great paper that uses DBZ from Tocris? Please let us know.
Reviews for DBZ
Average Rating: 3 (Based on 1 Review.)
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Differentiation of hiPSCs into optic progenitor cells.
For obtaining a higher solubility, I recommend warming at 37°C.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.