DBZ

Pricing Availability Delivery Time Qty
Cat.No. 4489 - DBZ | C26H23F2N3O3 | CAS No. 209984-56-5
Description: γ-secretase inhibitor; inhibits Notch pathway
Alternative Names: Dibenzazepine
Chemical Name: N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)

Biological Activity

Inhibitor of γ-secretase. Blocks Notch cleavage (IC50< 2 nM) in a cell-based assay; inhibits the Notch pathway. Stimulates the formation of human iPSCs from human keratinocytes.

Compound Libraries

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Technical Data

M. Wt 463.48
Formula C26H23F2N3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 209984-56-5
PubChem ID 11454028
InChI Key QSHGISMANBKLQL-OWJWWREXSA-N
Smiles CN1C2=C(C=CC=C2)C3=C(C=CC=C3)[C@H](NC([C@@H](NC(CC4=CC(F)=CC(F)=C4)=O)C)=O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.35 100

Preparing Stock Solutions

The following data is based on the product molecular weight 463.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.79 mL 21.58 mL
5 mM 0.43 mL 2.16 mL 4.32 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Groth et al (2010) Pharmacological analysis of Drosophila melanogaster γ-secretase with respect to differential proteolysis of Notch and APP. Mol.Pharmacol. 77 567 PMID: 20064975

van Es et al (2005) Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 435 959 PMID: 15959515

Ichida et al (2014) Notch inhibition allows oncogene-independent generation of iPS cells. Nat.Chem.Biol. 10 632 PMID: 24952596


If you know of a relevant reference for DBZ, please let us know.

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Keywords: Notch inhibitors inhibits gamma γ g-secretases signaling signalling pathways gamma-secretase amyloid stem cells iPSCs induced pluripotent reprogramming dedifferentiation Dibenzazepine Gamma-Secretase

2 Citations for DBZ

Citations are publications that use Tocris products. Selected citations for DBZ include:

Bi et al (2014) Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity. Nat Med 20 911 PMID: 25038826

Shah et al (2013) The role of Notch and γ-secretase inhibition in an ovarian cancer model. J Reprod Dev 33 801 PMID: 23482747


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