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Cat.No. 4489 - DBZ | C26H23F2N3O3 | CAS No. 209984-56-5
Description: γ-secretase inhibitor; inhibits Notch pathway
Alternative Names: Dibenzazepine
Chemical Name: N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
Purity: ≥98% (HPLC)
Citations (11)
Reviews (1)
Literature (4)

Biological Activity for DBZ

DBZ is an inhibitor of γ-secretase aspartyl protease. DBZ blocks amyloid precursor protein-like (APPL) and Notch cleavage (IC50 values are 2.6 nM and 1.7-2.9 nM, respectively). By inhibiting Notch and the Notch pathway, DBZ improves efficiency of iPSC generation and production of iPSCs from mouse and human keratinocytes without KLF4 and CMYC. In an animal model of Alzheimer's disease, DBZ inhibits the cleavage of amyloid precursor protein into Aβ40.

DBZ synthesized to Ancillary Material Grade also available.

Compound Libraries for DBZ

DBZ is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for DBZ

M. Wt 463.48
Formula C26H23F2N3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 209984-56-5
PubChem ID 11454028
Smiles CN1C2=C(C=CC=C2)C3=C(C=CC=C3)[C@H](NC([C@@H](NC(CC4=CC(F)=CC(F)=C4)=O)C)=O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DBZ

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 46.35 100

Preparing Stock Solutions for DBZ

The following data is based on the product molecular weight 463.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.79 mL 21.58 mL
5 mM 0.43 mL 2.16 mL 4.32 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets for DBZ

Certificate of Analysis / Product Datasheet
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References for DBZ

References are publications that support the biological activity of the product.

Groth et al (2010) Pharmacological analysis of Drosophila melanogaster γ-secretase with respect to differential proteolysis of Notch and APP. Mol.Pharmacol. 77 567 PMID: 20064975

van Es et al (2005) Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 435 959 PMID: 15959515

Ichida et al (2014) Notch inhibition allows oncogene-independent generation of iPS cells. Nat.Chem.Biol. 10 632 PMID: 24952596

If you know of a relevant reference for DBZ, please let us know.

View Related Products by Product Action

View all γ-Secretase Inhibitors

Keywords: DBZ, DBZ supplier, Notch, inhibitors, inhibits, gamma, γ, g-secretases, signaling, signalling, pathways, gamma-secretase, amyloid, stem, cells, iPSCs, induced, pluripotent, reprogramming, dedifferentiation, Dibenzazepine, Gamma-Secretase, Stem, Cell, Reprogramming, 4489, Tocris Bioscience

11 Citations for DBZ

Citations are publications that use Tocris products. Selected citations for DBZ include:

Marshall et al (2018) Analysis of the Intrinsic Self-Organising Properties of Mesenchymal Stromal Cells in Three-Dimensional Co-Culture Models with Endothelial Cells. Bioengineering (Basel) 5 PMID: 30373192

Page et al (2019) Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis. Cell Rep 27 3139 PMID: 31189101

Bi et al (2016) Stage-specific effects of Notch activation during skeletal myogenesis. Elife 5 PMID: 27644105

Shah et al (2013) The role of Notch and γ-secretase inhibition in an ovarian cancer model. J Reprod Dev 33 801 PMID: 23482747

Do you know of a great paper that uses DBZ from Tocris? Please let us know.

Reviews for DBZ

Average Rating: 3 (Based on 1 Review.)

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By Minjin Jeong on 09/09/2019
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: iPSCs

Differentiation of hiPSCs into optic progenitor cells.

For obtaining a higher solubility, I recommend warming at 37°C.

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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