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Biological Activity for Linifanib
Linifanib is a potent receptor tyrosine kinase (RTK) inhibitor. It inhibits PDGFRβ, KDR, FLT3, CSF-1R (IC50 values are 2, 4, 4 and 7 nM, respectively). Linifanib inhibits angiogenesis in vascularized micro-organs and potently inhibits VEGF-stimulated endothelial cell proliferation (IC50 = 0.2 nM). Linifanib also promotes the generation and reprogramming of iPSCs from somatic cells.
Technical Data for Linifanib
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Linifanib
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Linifanib
The following data is based on the product molecular weight 375.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.66 mL||13.32 mL||26.64 mL|
|5 mM||0.53 mL||2.66 mL||5.33 mL|
|10 mM||0.27 mL||1.33 mL||2.66 mL|
|50 mM||0.05 mL||0.27 mL||0.53 mL|
References for Linifanib
References are publications that support the biological activity of the product.
Albert et al (2006) Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Mol.Cancer Ther. 5 995 PMID: 16648571
Guan et al (2022) Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature 605 325 PMID: 35418683
Jahid et al (2022) Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer. Cell Rep. 39 110641 PMID: 35385746
If you know of a relevant reference for Linifanib, please let us know.
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Citations for Linifanib
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Currently there are no citations for Linifanib. Do you know of a great paper that uses Linifanib from Tocris? Please let us know.
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Literature in this Area
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