UNC 0224

Pricing Availability   Qty
Description: Potent G9a and GLP inhibitor
Chemical Name: 7-[3-(Dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for UNC 0224

UNC 0224 is a potent G9a and GLP inhibitor (IC50 values are 15 and 20 nM in a ThioGlo assay, respectively). Exhibits >1000-fold selectivity for G9a over SET7, SET8 and SET9. UNC 0224 can be used in protocols for the chemical reprogramming of somatic cells to iPSCs.

Technical Data for UNC 0224

M. Wt 485.67
Formula C26H43N7O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1197196-48-7
PubChem ID 44251522

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for UNC 0224

Solvent Max Conc. mg/mL Max Conc. mM
1eq. HCl 48.57 100
DMSO 48.57 100

Preparing Stock Solutions for UNC 0224

The following data is based on the product molecular weight 485.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.06 mL 10.3 mL 20.59 mL
5 mM 0.41 mL 2.06 mL 4.12 mL
10 mM 0.21 mL 1.03 mL 2.06 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

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Product Datasheets for UNC 0224

Certificate of Analysis / Product Datasheet
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References for UNC 0224

References are publications that support the biological activity of the product.

Liu et al (2009) Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. J.Med.Chem. 52 7950 PMID: 19891491

Guan et al (2022) Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature 605 325 PMID: 35418683

If you know of a relevant reference for UNC 0224, please let us know.

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Citations for UNC 0224

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics in Cancer Poster

Epigenetics in Cancer Poster

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