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Cat.No. 0761 - TTNPB | C24H28O2 | CAS No. 71441-28-6
Description: Retinoic acid analog; RAR agonist
Alternative Names: Ro 13-7410
Chemical Name: 4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid
Purity: ≥98% (HPLC)
Citations (3)

Biological Activity

Extremely potent analog of retinoic acid, selective for the retinoic acid receptor (RAR) subtype. Enhances reprogramming efficiency in chemically induced pluripotent stem cells (CiPSCs).

Technical Data

M. Wt 348.48
Formula C24H28O2
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 71441-28-6
PubChem ID 5289501
Smiles C\C(=C/C1=CC=C(C=C1)C(O)=O)C1=CC=C2C(=C1)C(C)(C)CCC2(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 3.48 10
ethanol 1.74 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 348.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.35 mL 28.7 mL
5 mM 0.57 mL 2.87 mL 5.74 mL
10 mM 0.29 mL 1.43 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Minucci et al (1996) Retinoid X receptor-selective ligands produce malformations in Xenopus embryos. Proc.Natl.Acad.Sci.U.S.A. 93 1803 PMID: 8700839

Loeliger et al (1980) Arotinoids, a new class of highly active retinoids. Eur.J.Med.Chem.-Chim.Ther. 15 9 PMID:

Hou et al (2013) Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science 341 651 PMID: 23868920

If you know of a relevant reference for TTNPB, please let us know.

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Keywords: TTNPB, supplier, Retinoic, acid, analogs, agonists, RAR, Receptors, Ro, 13-7410, Ro, 13-7410, Retinoic, Acid, Receptors, Reprogramming, Retinoic, Acid, Receptors, Tocris Bioscience

3 Citations for TTNPB

Citations are publications that use Tocris products. Selected citations for TTNPB include:

Thomas and Henry (2014) Retinoic acid regulation by CYP26 in vertebrate lens regeneration. Br J Pharmacol 386 291 PMID: 24384390

Chronopoulos et al (2016) ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion Nature Communications 7 12630 PMID: 27600527

Francipane and Lagasse (2015) The lymph node as a new site for kidney organogenesis. Stem Cells Transl Med 4 295 PMID: 25646529

Do you know of a great paper that uses TTNPB from Tocris? If so please let us know.

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