Pricing Availability   Qty
Description: Retinoic acid analog; RAR agonist
Alternative Names: Ro 13-7410
Chemical Name: 4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid
Purity: ≥98% (HPLC)
Citations (7)
Literature (1)

Biological Activity for TTNPB

TTNPB is an extremely potent analog of retinoic acid, selective for the retinoic acid receptor (RAR) subtype. Enhances reprogramming efficiency in chemically induced pluripotent stem cells (CiPSCs).

Technical Data for TTNPB

M. Wt 348.48
Formula C24H28O2
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 71441-28-6
PubChem ID 5289501
Smiles C\C(=C/C1=CC=C(C=C1)C(O)=O)C1=CC=C2C(=C1)C(C)(C)CCC2(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TTNPB

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 3.48 10

Preparing Stock Solutions for TTNPB

The following data is based on the product molecular weight 348.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.7 mL 143.48 mL 286.96 mL
0.5 mM 5.74 mL 28.7 mL 57.39 mL
1 mM 2.87 mL 14.35 mL 28.7 mL
5 mM 0.57 mL 2.87 mL 5.74 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for TTNPB

Certificate of Analysis / Product Datasheet
Select another batch:

References for TTNPB

References are publications that support the biological activity of the product.

Minucci et al (1996) Retinoid X receptor-selective ligands produce malformations in Xenopus embryos. Proc.Natl.Acad.Sci.U.S.A. 93 1803 PMID: 8700839

Loeliger et al (1980) Arotinoids, a new class of highly active retinoids. Eur.J.Med.Chem.-Chim.Ther. 15 9

Hou et al (2013) Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science 341 651 PMID: 23868920

If you know of a relevant reference for TTNPB, please let us know.

View Related Products by Product Action

View all Retinoic Acid Receptor Agonists

Keywords: TTNPB, TTNPB supplier, Retinoic, acid, analogs, agonists, RAR, Receptors, Ro, 13-7410, Acid, Stem, Cell, Reprogramming, 0761, Tocris Bioscience

7 Citations for TTNPB

Citations are publications that use Tocris products. Selected citations for TTNPB include:

Chronopoulos et al (2016) ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion Nature Communications 7 12630 PMID: 27600527

Tay et al (2010) A comparison of the roles of peroxisome proliferator-activated receptor and retinoic acid receptor on CYP26 regulation. Mol Pharmacol 77 218 PMID: 19884280

Francipane and Lagasse (2015) The lymph node as a new site for kidney organogenesis. Stem Cells Transl Med 4 295 PMID: 25646529

Thomas and Henry (2014) Retinoic acid regulation by CYP26 in vertebrate lens regeneration. Br J Pharmacol 386 291 PMID: 24384390

Do you know of a great paper that uses TTNPB from Tocris? Please let us know.

Reviews for TTNPB

There are currently no reviews for this product. Be the first to review TTNPB and earn rewards!

Have you used TTNPB?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Retinoid Receptors Scientific Review

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.