Tranylcypromine hydrochloride

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Cat.No. 3852 - Tranylcypromine hydrochloride | C9H11N.HCl | CAS No. 1986-47-6
Description: Irreversible inhibitor of LSD1; also inhibits MAO
Alternative Names: 2-PCPA
Chemical Name: (±)-trans-2-Phenylcyclopropylamine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (5)
Reviews
Protocols (1)
Literature

Biological Activity

Irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Inhibits histone demethylation. In combination with CHIR 99021 (Cat. No. 4423), enables reprogramming of mouse embryonic fibroblasts transduced by only two factors, Oct4 and Klf4, into induced pluripotent stem (iPS) cells.

Compound Libraries

Tranylcypromine hydrochloride is also offered as part of the Tocriscreen Plus, Tocriscreen Epigenetics Toolbox, Tocriscreen Library of FDA-Approved Compounds and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 169.65
Formula C9H11N.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1986-47-6
PubChem ID 2723716
InChI Key ZPEFMSTTZXJOTM-OULXEKPRSA-N
Smiles N[C@H]1[C@H]([C@]2=CC=CC=C2)C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 16.96 100
DMSO 16.96 100

Preparing Stock Solutions

The following data is based on the product molecular weight 169.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.89 mL 29.47 mL 58.94 mL
5 mM 1.18 mL 5.89 mL 11.79 mL
10 mM 0.59 mL 2.95 mL 5.89 mL
50 mM 0.12 mL 0.59 mL 1.18 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Lee et al (2006) Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem.Biol. 13 563 PMID: 16793513

Schmidt and McCafferty (2007) trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. Biochemistry 46 4408 PMID: 17367163

Li et al (2009) Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells 27 2992 PMID: 19839055


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View Related Products by Product Action

View all Histone Demethylase Inhibitors

Keywords: Tranylcypromine hydrochloride, Tranylcypromine hydrochloride supplier, irreversible, inhibitors, inhibits, monoamine, oxidase, A, B, MAOA, MAOB, lysine-specific, demethylase, 1, LSD1, BCH110, histone, demethylases, demethylation, oxygenases, oxidases, epigenetics, stem, cells, pluripotency, pluripotent, oct4, KDM1A, 2-PCPA, Monoamine, Oxidase, Other, Oxygenases/Oxidases, Reprogramming, Histone, Demethylases, 3852, Tocris Bioscience

5 Citations for Tranylcypromine hydrochloride

Citations are publications that use Tocris products. Selected citations for Tranylcypromine hydrochloride include:

Liu et al (2018) CRISPR-based chromatin remodeling of the endogenous Oct4 or Sox2 locus enables reprogramming to pluripotency. Cell Stem Cell 22 252 PMID: 29358044

Sun (2018) Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts. Bone Res 6 14 PMID: 29707403

Li et al (2011) Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell 21 196 PMID: 20956998

Zhang et al (2016) Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell 18 653 PMID: 27133794

Kearns et al (2015) Functional annotation of native enhancers with a Cas9-histone demethylase fusion. Nat Methods 12 401 PMID: 25775043


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Protocols for Tranylcypromine hydrochloride

The following protocol features additional information for the use of Tranylcypromine hydrochloride (Cat. No. 3852).

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

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