Irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Inhibits histone demethylation. In combination with CHIR 99021 (Cat. No. 4423), enables reprogramming of mouse embryonic fibroblasts transduced by only two factors, Oct4 and Klf4, into induced pluripotent stem (iPS) cells.
Tranylcypromine hydrochloride is also offered as part of the Tocriscreen Plus, Tocriscreen Epigenetics Toolbox, Tocriscreen Library of FDA-Approved Compounds and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 169.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.89 mL||29.47 mL||58.94 mL|
|5 mM||1.18 mL||5.89 mL||11.79 mL|
|10 mM||0.59 mL||2.95 mL||5.89 mL|
|50 mM||0.12 mL||0.59 mL||1.18 mL|
References are publications that support the biological activity of the product.
Lee et al (2006) Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem.Biol. 13 563 PMID: 16793513
Schmidt and McCafferty (2007) trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. Biochemistry 46 4408 PMID: 17367163
Li et al (2009) Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells 27 2992 PMID: 19839055
If you know of a relevant reference for Tranylcypromine hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Tranylcypromine hydrochloride, Tranylcypromine hydrochloride supplier, irreversible, inhibitors, inhibits, monoamine, oxidase, A, B, MAOA, MAOB, lysine-specific, demethylase, 1, LSD1, BCH110, histone, demethylases, demethylation, oxygenases, oxidases, epigenetics, stem, cells, pluripotency, pluripotent, oct4, KDM1A, 2-PCPA, Monoamine, Oxidase, Other, Oxygenases/Oxidases, Reprogramming, Histone, Demethylases, 3852, Tocris Bioscience
5 Citations for Tranylcypromine hydrochloride
Citations are publications that use Tocris products. Selected citations for Tranylcypromine hydrochloride include:
Zhang et al (2016) Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell 18 653 PMID: 27133794
Liu et al (2018) CRISPR-based chromatin remodeling of the endogenous Oct4 or Sox2 locus enables reprogramming to pluripotency. Cell Stem Cell 22 252 PMID: 29358044
Sun (2018) Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts. Bone Res 6 14 PMID: 29707403
Li et al (2011) Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell 21 196 PMID: 20956998
Kearns et al (2015) Functional annotation of native enhancers with a Cas9-histone demethylase fusion. Nat Methods 12 401 PMID: 25775043
Do you know of a great paper that uses Tranylcypromine hydrochloride from Tocris? Please let us know.
Reviews for Tranylcypromine hydrochloride
There are currently no reviews for this product. Be the first to review Tranylcypromine hydrochloride and earn rewards!
Have you used Tranylcypromine hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Protocols for Tranylcypromine hydrochloride
The following protocol features additional information for the use of Tranylcypromine hydrochloride (Cat. No. 3852).
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics Research Bulletin
Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:
- DNA Methyltransferases
- Histone Deacetylases
- Histone Demethylases
- Histone Methyltransferases