Bexarotene

Pricing Availability Delivery Time Qty
Cat.No. 5819 - Bexarotene | C24H28O2 | CAS No. 153559-49-0
Description: Potent and selective RXR agonist
Alternative Names: LGD 1069
Chemical Name: 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent and selective RXR agonist (EC50 values are 24, 25 and 33 nM for RXRβ, RXRγ and RXRα, respectively). Exhibits >300-fold selectivity for RXR over RAR receptors. Inhibits tumor cell invasion and migration in vitro, and inhibits metastasis and angiogenesis in mouse models. Also promotes brown adipogenic differentiation and induces brown adipogenic reprogramming from myoblasts.

Technical Data

M. Wt 348.48
Formula C24H28O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 153559-49-0
PubChem ID 82146
InChI Key NAVMQTYZDKMPEU-UHFFFAOYSA-N
Smiles CC(CCC(C)2C)(C)C1=C2C=C(C)C(C(C3=CC=C(C(O)=O)C=C3)=C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 6.97 20 with gentle warming
DMSO 34.85 100

Preparing Stock Solutions

The following data is based on the product molecular weight 348.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.35 mL 28.7 mL
5 mM 0.57 mL 2.87 mL 5.74 mL
10 mM 0.29 mL 1.43 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Boehm et al (1994) Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids. J.Med.Chem. 37 2930 PMID: 8071941

Yen et al (2006) A selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) inhibits angiogenesis and metastasis in solid tumours. Br.J.Cancer 94 654 PMID: 16495926

Nie et al (2017) Brown adipogenic reprogramming induced by a small molecule. Cell Rep. 18 624 PMID: 28099842


If you know of a relevant reference for Bexarotene, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Retinoid X Receptor Agonists

Keywords: Bexarotene, Bexarotene supplier, retinoid, X, receptors, agonists, agonism, RXR, α, β, γ, alpha, beta, gamma, potent, selective, cancer, metastasis, angiogenesis, LG1069, stem, cells, differentiation, brown, adipocytes, adipogenic, reprogramming, LGD1069, Retinoid, Receptor, Reprogramming, 5819, Tocris Bioscience

1 Citation for Bexarotene

Citations are publications that use Tocris products. Selected citations for Bexarotene include:

Hebert (2017) Effects of retinoic acid signaling on extraocular muscle myogenic precursor cells in vitro. Exp Cell Res 361 101 PMID: 29017757


Do you know of a great paper that uses Bexarotene from Tocris? Please let us know.

Reviews for Bexarotene

There are currently no reviews for this product. Be the first to review Bexarotene and earn rewards!

Have you used Bexarotene?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors
Retinoid Receptors

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.