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Cat.No. 5819 - Bexarotene | C24H28O2 | CAS No. 153559-49-0
Description: Potent and selective RXR agonist
Alternative Names: LGD 1069
Chemical Name: 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity

Potent and selective RXR agonist (EC50 values are 24, 25 and 33 nM for RXRβ, RXRγ and RXRα, respectively). Exhibits >300-fold selectivity for RXR over RAR receptors. Inhibits tumor cell invasion and migration in vitro, and inhibits metastasis and angiogenesis in mouse models. Also promotes brown adipogenic differentiation and induces brown adipogenic reprogramming from myoblasts.

Technical Data

M. Wt 348.48
Formula C24H28O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 153559-49-0
PubChem ID 82146
Smiles CC(CCC(C)2C)(C)C1=C2C=C(C)C(C(C3=CC=C(C(O)=O)C=C3)=C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.85 100
ethanol 6.97 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 348.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.35 mL 28.7 mL
5 mM 0.57 mL 2.87 mL 5.74 mL
10 mM 0.29 mL 1.43 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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References are publications that support the products' biological activity.

Boehm et al (1994) Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids. J.Med.Chem. 37 2930 PMID: 8071941

Yen et al (2006) A selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) inhibits angiogenesis and metastasis in solid tumours. Br.J.Cancer 94 654 PMID: 16495926

Nie et al (2017) Brown adipogenic reprogramming induced by a small molecule. Cell Rep. 18 624 PMID: 28099842

If you know of a relevant reference for Bexarotene, please let us know.

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Keywords: Bexarotene, supplier, retinoid, X, receptors, agonists, agonism, RXR, α, β, γ, alpha, beta, gamma, potent, selective, cancer, metastasis, angiogenesis, LG1069, stem, cells, differentiation, brown, adipocytes, adipogenic, reprogramming, LGD1069, Retinoid, X, Receptor, Reprogramming, Retinoid, X, Receptor, Tocris Bioscience

1 Citation for Bexarotene

Citations are publications that use Tocris products. Selected citations for Bexarotene include:

Hebert (2017) Effects of retinoic acid signaling on extraocular muscle myogenic precursor cells in vitro. Exp Cell Res 361 101 PMID: 29017757

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