BIRB 796

Pricing Availability   Qty
Description: High affinity and selective p38 kinase inhibitor
Alternative Names: Doramapimod
Chemical Name: N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea
Purity: ≥98% (HPLC)
Datasheet
Citations (12)
Reviews
Literature (1)
Pathways (1)

Biological Activity for BIRB 796

BIRB 796 is a high affinity and selective p38 kinase inhibitor (Kd = 50-100 pM). Exhibits no significant inhibition on a panel of related kinases. Inhibits LPS-induced TNFα production in human PBMCs and whole blood (IC50 values are 21 and 960 nM, respectively). Also inhibits JNK2α2 and c-Raf-1 (IC50 values are 98 nM and 1.4 μM, respectively). BIRB 796 can be used in protocols for the chemical reprogramming of somatic cells to iPSCs. Cell permeable.

Compound Libraries for BIRB 796

BIRB 796 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for BIRB 796

M. Wt 527.66
Formula C31H37N5O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 285983-48-4
PubChem ID 156422
InChI Key MVCOAUNKQVWQHZ-UHFFFAOYSA-N
Smiles CC1=CC=C(N2N=C(C(C)(C)C)C=C2NC(NC3=CC=C(C4=C3C=CC=C4)OCCN5CCOCC5)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BIRB 796

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.28 10

Preparing Stock Solutions for BIRB 796

The following data is based on the product molecular weight 527.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.95 mL 94.76 mL 189.52 mL
0.5 mM 3.79 mL 18.95 mL 37.9 mL
1 mM 1.9 mL 9.48 mL 18.95 mL
5 mM 0.38 mL 1.9 mL 3.79 mL

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Product Datasheets for BIRB 796

Certificate of Analysis / Product Datasheet
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View Related Products by Product Action

View all p38 MAPK Inhibitors

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12 Citations for BIRB 796

Citations are publications that use Tocris products. Selected citations for BIRB 796 include:

Crozier et al (2023) CDK4/6 inhibitor-mediated cell overgrowth triggers osmotic and replication stress to promote senescence. Mol.Cell 83 4062 PMID: 37977118

Harold A et al (2020) Distinct Airway Epithelial Stem Cells Hide among Club Cells but Mobilize to Promote Alveolar Regeneration. Cell Stem Cell 26 346-358.e4 PMID: 31978363

Richard C et al (2020) Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction. Cell Stem Cell 27 890-904.e8 PMID: 33128895

Markus et al (2021) p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway. Cell Stress 5 176-182 PMID: 34917890


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for BIRB 796

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.