Trichostatin A

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Cat.No. 1406 - Trichostatin A | C17H22N2O3 | CAS No. 58880-19-6
Description: Potent histone deacetylase inhibitor
Chemical Name: (2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
Purity: ≥98% (HPLC)
Citations (8)
Literature (3)

Biological Activity for Trichostatin A

Trichostatin A is a selective and potent inhibitor of histone deacetylase (Ki = 3.4 nM). Active in vivo. Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells. Activates autophagy.

Technical Data for Trichostatin A

M. Wt 302.37
Formula C17H22N2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 58880-19-6
PubChem ID 444732
Smiles O=C([C@H](C)/C=C(C)/C=C/C(NO)=O)C1=CC=C(N(C)C)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Trichostatin A

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 5 17

Preparing Stock Solutions for Trichostatin A

The following data is based on the product molecular weight 302.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.17 mM 19.45 mL 97.27 mL 194.54 mL
0.85 mM 3.89 mL 19.45 mL 38.91 mL
1.7 mM 1.95 mL 9.73 mL 19.45 mL
8.5 mM 0.39 mL 1.95 mL 3.89 mL

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Product Datasheets for Trichostatin A

Certificate of Analysis / Product Datasheet
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References for Trichostatin A

References are publications that support the biological activity of the product.

Durcova-Hills et al (2008) Reprogramming primordial germ cells into pluripotent stem cells. PloS ONE 3 e3531 PMID: 18953407

Yoshida et al (1990) Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J.Biol.Chem. 265 17174 PMID: 2211619

Vigushin et al (2001) Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin.Cancer Res. 7 971 PMID: 11309348

Wharton et al (2000) Inhibition of mitogenesis in Balb/c-3T3 cells by trichostatin A. J.Biol.Chem. 275 33981 PMID: 10945992

Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316

If you know of a relevant reference for Trichostatin A, please let us know.

View Related Products by Product Action

View all Non-selective Histone Deacetylase Inhibitors

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8 Citations for Trichostatin A

Citations are publications that use Tocris products. Selected citations for Trichostatin A include:

Lu et al (2019) Histone deacetylase 4 promotes type I IF. signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6. Proc Natl Acad Sci U S A PMID: 31127039

Kurita et al (2012) HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci 15 1245 PMID: 22864611

Xia et al (2013) Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther 14 638 PMID: 23792643

Parira et al (2019) Trichostatin A Shows Transient Protection from Chronic Alcohol-Induced Reactive Oxygen Species (ROS) Production in Human Monocyte-Derived Dendritic Cells. J Alcohol Drug Depend 6 PMID: 30596124

Do you know of a great paper that uses Trichostatin A from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.


Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

  • Bromodomains
  • DNA Methyltransferases
  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases
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