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DBIA

Cat. No. 8142 Submit a Review Datasheet / COA / SDS
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Description: Chemoproteomic reagent, binds with reactive cysteines and labels with desthiobiotin
Chemical Name: (4R,5S)-N-[2-[(2-Iodoacetyl)amino]ethyl]-5-methyl-2-oxo-4-imidazolidinehexanamide
Purity: ≥95% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for DBIA

DBIA (desthiobiotin iodoacetamide) is a chemoproteomic reagent. DBIA is a cysteine reactive probe used to label and purify proteins by attaching desthiobiotin to cysteine residues in the protein of interest. DBIA can be used for targeted protein labeling and purification studies.

Technical Data for DBIA

M. Wt 424.28
Formula C14H25IN4O3
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2924824-04-2
PubChem ID 166642567
InChI Key ASKKBTGJVCEXOA-WDEREUQCSA-N
Smiles ICC(NCCNC(CCCCC[C@@H]1[C@@H](NC(N1)=O)C)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DBIA

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.43 100

Preparing Stock Solutions for DBIA

The following data is based on the product molecular weight 424.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.78 mL 23.57 mL
5 mM 0.47 mL 2.36 mL 4.71 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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References for DBIA

References are publications that support the biological activity of the product.

Kuljanin et al (2021) Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat.Biotechnol. 39 630 PMID: 33398154

If you know of a relevant reference for DBIA, please let us know.

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Citations for DBIA

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