Stem Cell Reprogramming Other

Cat. No. Product Name / Activity
4055 L-Ascorbic acid
Enhances the generation of iPSCs; increases reprogramming efficiency
3842 5-Azacytidine
DNA methyltransferase inhibitor; improves reprogramming efficiency
1544 (±)-Bay K 8644
Ca2+ channel activator (L-type); aids generation of iPSCs from MEFs
5819 Bexarotene
Potent and selective RXR agonist; induces brown adipogenic reprogramming from myoblasts
5989 BIRB 796
Used in the reprogramming of somatic cells to ciPSCs; high affinity and selective p38 kinase inhibitor
3364 BIX 01294
GLP and G9a inhibitor; potentiates induction of iPSCs
5015 5-BrdU
Enhances Yamanaka factor reprogramming and replaces Oct-4 in transcription factor-mediated reprogramming; synthetic thymidine analog
6695 CHIR 98014
Highly potent and selective GSK-3 inhibitor; can be used in differentiation and reprogramming of stem cells
4423 CHIR 99021
Highly selective GSK-3 inhibitor; enables reprogramming of mouse embryonic fibroblasts into iPS cells
7163 Chroman 1
Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis
5331 CPI 203
Enhances reprogramming at low concentration; BET bromodomain inhibitor
4489 DBZ
Notch signaling pathway inhibitor; stimulates formation of iPSCs
4703 3-Deazaneplanocin A hydrochloride
Histone methyltransferase inhibitor; enhances Oct4 expression in chemically-induced pluripotent stem cells
1425 (S)-(+)-Dimethindene maleate
Allows formation of extended pluripotent stem (EPS) cells; also M2-selective antagonist
4126 DMH-1
Used in the reprogramming of somatic cells to ciPSCs; selective ALK2 inhibitor
3093 Dorsomorphin dihydrochloride
Used in the reprogramming of somatic cells to ciPSCs; BMP type I receptor inhibitor
6340 Epiblastin A
Converts epiblast stem cells to ESCs and promotes ESC self-renewal; CK1 inhibitor
5567 EPZ 004777
Improves reprogramming efficiency; highly potent DOT1L inhibitor
7807 Hh-Ag1.5
Promotes mouse embryonic fibroblasts reprogramming into neural stem cells; potent and high affinity Smo receptor agonist
3533 IWP 2
Used in the reprogramming of somatic cells to ciPSCs; PORCN inhibitor
6976 JNJ 10198409
Induces reprogramming of fibroblasts into functional cardiomyocytes (9C cocktail); potent PDGFRα and PDGFRβ inhbitor
1398 Kenpaullone
Promotes generation of iPSCs from somatic cells; inhibits GSK-3β and cdks
7743 Linifanib
Promotes generation and reprogramming of iPSCs; also potent inhibitor of PDGFRβ, KDR, FLT3 and CSF-1R
3268 Minocycline hydrochloride
Allows formation of extended pluripotent stem (EPS) cells; also antibiotic
3656 Neurodazine
Induces neurogenesis in mature skeletal muscle cells
5664 O4I2
Oct3/4 inducer; induces expression of pluripotent-associated genes
4192 PD 0325901
Selective inhibitor of MEK1/2; enhances generation of iPSCs
2653 Pifithrin-μ
Inhibitor of p53-mitochondrial binding
7739 Polyamine Supplement x1000 (lyophilized)
Media supplement to boost cell growth; used as component of CEPT cocktail to enhance stem cell viability
3742 RepSox
Selective TGF-βRI inhibitor; enhances reprogramming efficiency
3295 RG 108
Non-nucleoside DNA methyltransferase inhibitor; enhances efficiency of iPSC generation
7064 Ruxolitinib
Used in the reprogramming of somatic cells to ciPSCs; JAK 1/2 inhibitor
6390 SAG dihydrochloride
Used in the reprogramming of somatic cells to ciPSCs; Smo receptor agonist
4652 SAHA
Increases efficiency of OSKM-induced reprogramming of MEFs to iPSCs; class I and II HDAC inhibitor
1614 SB 431542
Replaces SOX2 in reprogramming protocols; potent and selective inhibitor of TGF-βRI, ALK4 and ALK7
2650 SB 590885
Used in the reprogramming of somatic cells to ciPSCs; B-Raf inhibitor inhibitor
4889 SGC-CBP30
Used in the reprogramming of somatic cells to ciPSCs; potent CBP/p300 BRD inhibitor
4297 SMER 28
Promotes reprogramming of fibroblasts to neural stem-like cells
3845 Thiazovivin
Improves the efficiency of fibroblast reprogramming and induction of iPSCs; ROCK inhibitor
7340 Tocriscreen Stem Cell Library
A library of 120 stem cell compounds (100 μL 10 mM DMSO solutions) to explore stem cell reprogramming, differentiation, proliferation and signaling
3852 Tranylcypromine hydrochloride
Irreversible inhibitor of LSD1; enables reprogramming of mouse embryonic fibroblasts into iPS cells
1406 Trichostatin A
Potent histone deacetylase inhibitor; induces accelerated dedifferentiation of primordial germ cells
0761 TTNPB
Retinoic acid analog; enhances efficiency of reprogramming in CiPSCs
3861 UNC 0224
Used in the reprogramming of somatic cells to ciPSCs; G9a and GLP inhibitor
2815 Valproic acid, sodium salt
Histone deacetylase inhibitor; enables induction of pluripotent stem cells from somatic cells
1254 Y-27632 dihydrochloride
Selective ROCK inhibitor; part of cocktail used to induce neurons from fibroblasts