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Biological Activity for Hh-Ag1.5
Hh-Ag1.5 is a potent and high affinity Smoothened (Smo) receptor agonist (EC50 = 1 nM; Ki values are 0.5 and 2.3 nM respectively, in a [3H]SAG-1.3 and [3H]Cyclopamine binding assay). It is used in protocols for the chemical reprogramming of mouse embryonic fibroblasts into neural stem cells. Also induces differentiation of hiPSCs into skin-derived precursor cells, spinal motor neurons and spinal sensory neurons.
Technical Data for Hh-Ag1.5
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Hh-Ag1.5
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Hh-Ag1.5
The following data is based on the product molecular weight 526.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.9 mL||9.5 mL||19.01 mL|
|5 mM||0.38 mL||1.9 mL||3.8 mL|
|10 mM||0.19 mL||0.95 mL||1.9 mL|
|50 mM||0.04 mL||0.19 mL||0.38 mL|
References for Hh-Ag1.5
References are publications that support the biological activity of the product.
Frank-Kamenetsky et al (2002) Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J.Biol. 1 10 PMID: 12437772
Rominger et al (2009) Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J.Pharmacol.Exp.Ther. 329 995 PMID: 19304771
Takeda et al (2018) Chemical compound-based direct reprogramming for future clinical applications. Biosci.Rep. 38 BSR20171650 PMID: 29739872
Sugiyama-Nakagiri et al (2016) Induction of skin-derived precursor cells from human induced pluripotent stem cells. PLoS One 11 e0168451 PMID: 27992514
If you know of a relevant reference for Hh-Ag1.5, please let us know.
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Citations for Hh-Ag1.5
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Literature in this Area
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