SMER 28

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Cat.No. 4297 - SMER 28 | C11H10BrN3 | CAS No. 307538-42-7
Description: Positive regulator of autophagy
Chemical Name: 6-Bromo-N-2-propenyl-4-quinazolinamine
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Positive regulator of autophagy in a mechanism independent from the mTOR pathway. Increases autophagosome synthesis and enhances clearance of model autophagy substrates such as mutant huntingtin and A53T α-synuclein, associated with Huntington's and Parkinson's diseases, respectively. Promotes reprogramming of fibroblasts to neural stem-like cells in combination with other chemical reagents.

Compound Libraries

SMER 28 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 264.12
Formula C11H10BrN3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 307538-42-7
PubChem ID 1560402
InChI Key BCPOLXUSCUFDGE-UHFFFAOYSA-N
Smiles C=CCNC2=NC=NC1=CC=C(Br)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.41 100
ethanol (supplied pre-dissolved in absolute ethanol, 27µg/ml) 13.21 50

Preparing Stock Solutions

The following data is based on the product molecular weight 264.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.79 mL 18.93 mL 37.86 mL
5 mM 0.76 mL 3.79 mL 7.57 mL
10 mM 0.38 mL 1.89 mL 3.79 mL
50 mM 0.08 mL 0.38 mL 0.76 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Renna et al (2010) Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J.Biol.Chem. 285 11061 PMID: 20147746

Sarkar et al (2010) Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat.Chem.Biol. 3 331 PMID: 17486044

Zhang et al (2016) Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell 18 653 PMID: 27133794


If you know of a relevant reference for SMER 28, please let us know.

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Keywords: SMER28 autophagy inducer induces modulates autophagy MTOR-independent small-molecule enhancers SMERs Autophagy

1 Citation for SMER 28

Citations are publications that use Tocris products. Selected citations for SMER 28 include:

Zhang et al (2016) Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell 18 653 PMID: 27133794


Do you know of a great paper that uses SMER 28 from Tocris? If so please let us know.

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Reviews

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Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

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Autophagy

Autophagy Scientific Review

Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.

Autophagy

Autophagy Poster

Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.

Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for SMER 28

Protocols

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