CD 3254

Pricing Availability Delivery Time Qty
Cat.No. 3302 - CD 3254 | C24H28O3 | CAS No. 196961-43-0
Description: Potent and selective RXRα agonist.
Chemical Name: 3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoic acid
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective RXRα agonist; exhibits no activity at RARα, RARβ or RARγ receptors.

Compound Libraries

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Technical Data

M. Wt 364.48
Formula C24H28O3
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 196961-43-0
PubChem ID 44566110
InChI Key DYLLZSVPAUUSSB-VQHVLOKHSA-N
Smiles CC1(C)C2=C(C=C(C3=C(O)C=CC(/C=C/C(O)=O)=C3)C(C)=C2)C(C)(C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.45 100
ethanol 36.45 100

Preparing Stock Solutions

The following data is based on the product molecular weight 364.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.72 mL 27.44 mL
5 mM 0.55 mL 2.74 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Pogenberg et al (2005) Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies. J.Biol.Chem. 280 1625 PMID: 15528208

le Maire et al (2009) Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors. EMBO.Rep. 10 367 PMID: 19270714

Nahoum et al (2007) Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function. Proc.Natl.Acad.Sci. 104 17323 PMID:


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Keywords: CD 3254, supplier, Potent, selective, RXR, agonists, CD3254, aRXR, alphaRXR, αRXR, retinoid, X, receptor, Retinoid, X, Receptor, Retinoid, X, Receptor, Tocris Bioscience

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