You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Highly potent and selective GSK-3 inhibitor (IC50 values are 0.58 and 0.65 nM for the β and α isoforms, respectively). Exhibits >500-fold selectivity for GSK-3β over a range of other kinases. Improves insulin sensitivity of muscle strips from diabetic rats in vitro and decreases insulin and glucose levels in the oral glucose tolerance test in vivo. Activates Wnt signaling in human adipose stem cells (hASC) and promotes the production of definitive endoderm. Has been used in protocols to derive epicardial cells from hPSCs.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||9.73||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 486.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||10.28 mL||51.41 mL||102.82 mL|
|1 mM||2.06 mL||10.28 mL||20.56 mL|
|2 mM||1.03 mL||5.14 mL||10.28 mL|
|10 mM||0.21 mL||1.03 mL||2.06 mL|
References are publications that support the biological activity of the product.
Ring et al (2003) Selective glycogen synthase kinase 3 inhibitors potentiate Ins activation of glucose transport and utilization in vitro and in vivo. Diabetes 52 588 PMID: 12606497
Paik and Wu et al (2017) Simply derived epicardial cells. Nat.Biomed.Eng. 1 PMID: 29354320
Huang et al (2017) Activation of Wnt/β-catenin signalling via GSK3 inhibitors direct differentiation of human adipose stem cells into functional hepatocytes. Sci.Rep. 7 40716 PMID: 28094799
If you know of a relevant reference for CHIR 98014, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: CHIR 98014, CHIR 98014 supplier, CHIR98014, glycogen, synthase, kinase, 3, alpha, alfa, beta, β, α, inhibitors, inhibits, highly, potent, selective, GSK, Wnt, signaling, activates, activators, reprogramming, epicardial, cells, Glycogen, Synthase, Kinase, Stem, Cell, Reprogramming, 6695, Tocris Bioscience
Citations for CHIR 98014
Citations are publications that use Tocris products.
Currently there are no citations for CHIR 98014. Do you know of a great paper that uses CHIR 98014 from Tocris? Please let us know.
Reviews for CHIR 98014
There are currently no reviews for this product. Be the first to review CHIR 98014 and earn rewards!
Have you used CHIR 98014?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.