CHIR 98014

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Description: Highly potent and selective GSK-3 inhibitor
Chemical Name: N6-[2-[[4-(2,4-Dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-pyridinediamine
Purity: ≥98% (HPLC)
Literature (4)
Pathways (1)

Biological Activity for CHIR 98014

CHIR 98014 is a highly potent and selective GSK-3 inhibitor (IC50 values are 0.58 and 0.65 nM for the β and α isoforms, respectively). Exhibits >500-fold selectivity for GSK-3β over a range of other kinases. Improves insulin sensitivity of muscle strips from diabetic rats in vitro and decreases insulin and glucose levels in the oral glucose tolerance test in vivo. Activates Wnt signaling in human adipose stem cells (hASC) and promotes the production of definitive endoderm. Has been used in protocols to derive epicardial cells from hPSCs.

Technical Data for CHIR 98014

M. Wt 486.31
Formula C20H17Cl2N9O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 252935-94-7
PubChem ID 53396311
Smiles NC1=NC(NCCNC2=NC=C(C(C3=C(C=C(C=C3)Cl)Cl)=N2)N4C=CN=C4)=CC=C1[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CHIR 98014

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 9.73 20 with gentle warming

Preparing Stock Solutions for CHIR 98014

The following data is based on the product molecular weight 486.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 10.28 mL 51.41 mL 102.82 mL
1 mM 2.06 mL 10.28 mL 20.56 mL
2 mM 1.03 mL 5.14 mL 10.28 mL
10 mM 0.21 mL 1.03 mL 2.06 mL

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Product Datasheets for CHIR 98014

Certificate of Analysis / Product Datasheet
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References for CHIR 98014

References are publications that support the biological activity of the product.

Ring et al (2003) Selective glycogen synthase kinase 3 inhibitors potentiate Ins activation of glucose transport and utilization in vitro and in vivo. Diabetes 52 588 PMID: 12606497

Paik and Wu et al (2017) Simply derived epicardial cells. Nat.Biomed.Eng. 1 PMID: 29354320

Huang et al (2017) Activation of Wnt/β-catenin signalling via GSK3 inhibitors direct differentiation of human adipose stem cells into functional hepatocytes. Sci.Rep. 7 40716 PMID: 28094799

If you know of a relevant reference for CHIR 98014, please let us know.

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Citations for CHIR 98014

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Stem Cell Research Product Guide

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

  • Self-renewal and Maintenance
  • Differentiation
  • Reprogramming
  • Organoid Generation
  • GMP and Ancillary Material Grade Products
Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

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Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.

Stem Cells Poster

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.

Pathways for CHIR 98014

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.