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Submit ReviewLTGO-33 New
Description: Potent and selective state-independent inhibitor of NaV1.8 sodium channels
Chemical Name: (R)-2-(4-Fluoro-2-methylphenoxy)-N-(3-(S-methylsulfonimidoyl)phenyl)-5-(trifluoromethyl)nicotinamide
Purity: ≥98% (HPLC)
Biological Activity for LTGO-33
LTGO-33 is a potent and selective state-independent inhibitor of NaV1.8 sodium channels (IC50 = 13 nM for the closed state; IC50 = 24 nM for the inactive state). It displays 600-fold selectivity over other sodium channels such as NaV1.1-1.7 and NaV1.9. By binding to NaV1.8 channels, LTGO-33 inhibits action potential initiation and transmission of pain signals in human DRG neurons. Unlike other NaV1.8 inhibitors that preferentially interact with an inactivated state via the pore region, LTGO-33 is state-independent with similar potencies against closed and inactivated channels.
Licensing Information
Sold with kind permission of Latigo Biotherapeutics
Technical Data for LTGO-33
| M. Wt | 467.44 |
| Formula | C21H17F4N3O3S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2834106-06-6 |
| PubChem ID | 169124157 |
| InChI Key | IIJWTXGHWFZLBF-JGCGQSQUSA-N |
| Smiles | N=[S@](C1=CC=CC(NC(C2=C(N=CC(C(F)(F)F)=C2)OC3=C(C=C(C=C3)F)C)=O)=C1)(C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LTGO-33
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.74 | 100 | |
| ethanol | 46.74 | 100 |
Preparing Stock Solutions for LTGO-33
The following data is based on the product molecular weight 467.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.14 mL | 10.7 mL | 21.39 mL |
| 5 mM | 0.43 mL | 2.14 mL | 4.28 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.14 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
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Product Datasheets for LTGO-33
References for LTGO-33
References are publications that support the biological activity of the product.
Gilchrist et al (2024) Pharmacologic characterization of LTGO-33, a selective small molecule inhibitor of the voltage-gated sodium channel NaV1.8 with a unique mechanism of action. Mol.Pharmacol 105 233 PMID: 38195157
If you know of a relevant reference for LTGO-33, please let us know.
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Citations for LTGO-33
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