Purinergic (P2Y) Receptors

P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Data


Cat No Product Name / Activity
3245 ATP disodium salt
P2 agonist
4080 ATPγS tetralithium salt
P2 agonist; ATP (Cat. No. 3245) analog
3312 BzATP triethylammonium salt
P2Y1 partial agonist. Also P2X7 agonist and P2X1 partial agonist
3209 α,β-Methyleneadenosine 5'-triphosphate trisodium salt
P2 agonist
1624 2-Methylthioadenosine diphosphate trisodium salt
Potent agonist for P2Y1, P2Y12 and P2Y13
1062 2-Methylthioadenosine triphosphate tetrasodium salt
P2 agonist
2157 MRS 2365
Highly potent and selective P2Y1 agonist
2915 MRS 2690
Potent P2Y14 agonist
2502 MRS 2693 trisodium salt
Selective P2Y6 agonist
3884 MRS 2768 tetrasodium salt
Selective P2Y2 agonist
5633 MRS 2905
Potent and selective P2Y14 receptor agonist
4260 MRS 2957 triethylammonium salt
Potent and selective P2Y6 agonist
4261 MRS 4062 triethylammonium salt
Selective P2Y4 receptor agonist
3892 NF 546
Selective P2Y11 agonist
4376 5-OMe-UDP trisodium salt
Potent P2Y6 agonist
2715 PSB 0474
Potent and selective P2Y6 agonist
4333 PSB 1114
Potent, selective P2Y2 agonist
3280 2-ThioUTP tetrasodium salt
Potent and selective P2Y2 agonist
3279 UTPγS trisodium salt
Selective P2Y2/4 agonist


Cat No Product Name / Activity
4890 AR-C 118925XX
Selective, competitive P2Y2 receptor antagonist
3321 AR-C 66096 tetrasodium salt
Potent and selective P2Y12 antagonist
5720 AR-C 69931 tetrasodium salt
Highly potent P2Y12 antagonist
6085 AZD 1283
High affinity P2Y12 antagonist
6078 BPTU
P2Y1 allosteric antagonist
1820 (+)-Clopidogrel hydrogen sulfate
Selective P2Y12 antagonist
2490 (±)-Clopidogrel hydrochloride
Selective P2Y12 antagonist
5316 Elinogrel
P2Y12 antagonist
0900 MRS 2179 tetrasodium salt
Selective P2Y1 antagonist
2402 MRS 2211
Competitive P2Y13 antagonist
2158 MRS 2279
Selective, high affinity P2Y1 antagonist
2159 MRS 2500 tetraammonium salt
Extremely potent and selective P2Y1 antagonist
2146 MRS 2578
Selective P2Y6 antagonist
2450 NF 157
Selective P2Y11/P2X1 antagonist
3830 NF 340
Selective P2Y11 antagonist
0625 PPADS tetrasodium salt
P2 antagonist
4862 PPTN hydrochloride
High affinity and selective P2Y14 antagonist
6317 Prasugrel
Irreversible P2Y12 antagonist; antiplatelet and orally active
3983 PSB 0739
Highly potent P2Y12 receptor antagonist
5650 SAR 216471 hydrochloride
Potent P2Y12 antagonist; orally available
1472 Suramin hexasodium salt
Non-selective P2 antagonist
3931 Ticlopidine hydrochloride
Selective P2Y12 antagonist


Cat No Product Name / Activity
5157 DMNPE-caged ATP diammonium salt
Caged ATP
1682 PIT
P2Y ligand; displays mixed antagonism/potentiation
3111 UDP disodium salt
Endogenous ligand; competitive antagonist at P2Y14 receptors

P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10 receptors are considered to be orphan receptors, and p2y5 is now known as a leukotriene B4 receptor.

P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13 and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades including PLCβ, PLD, PLA2, AC and MAPK/MEK kinase.

P2Y receptors are found in most human tissues. They have diverse physiological roles including regulation of platelet aggregation, muscle contraction, neurotransmission, epithelial cell communication and migration, as well as immune response.

External sources of pharmacological information for Purinergic (P2Y) Receptors :

Literature for Purinergic (P2Y) Receptors

Tocris offers the following scientific literature for Purinergic (P2Y) Receptors to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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P2X and P2Y Receptors

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.


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P2Y Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
P2Y1 Human P2RY1 NM_002563 P47900
Mouse P2ry1 NM_008772 P49650
Rat P2ry1 NM_012800 P49651
P2Y2 Human P2RY2 NM_176072 P41231
Mouse Pyry2 NM_008773 P35383
Rat P2ry2 NM_017255 P41232
P2Y4 Human P2RY4 NM_002565 P51582
Mouse P2ry4 NM_020621 Q9JJS7
Rat P2ry4 NM_031680 O35811
P2Y6 Human P2RY6 NM_176798 Q15077
Mouse P2ry6 NM_183168 Q9ERK9
Rat P2ry6 NM_057124 Q63371
P2Y11 Human P2RY11 NM_002566 Q96G91
P2Y12 Human P2RY12 NM_022788 Q9H244
Mouse P2ry12 NM_027571 Q9CPV9
Rat P2ry12 NM_022800 Q9EPX4
P2Y13 Human P2RY13 NM_023914 Q9BPV8
Mouse P2ry13 NM_028808 Q9D8I2
Rat P2ry13 NM_001002853 Q6GUG4
P2Y14 Human P2RY14 NM_014879 Q15391
Mouse P2ry14 NM_133200 Q9ESG6
Rat P2ry14 NM_133577 O35881