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Submit ReviewPPTN hydrochloride
Description: High affinity and selective P2Y14 antagonist
Chemical Name: 4-[4-(4-Piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for PPTN hydrochloride
PPTN hydrochloride is a high affinity and selective P2Y14 antagonist (KB = 434 pM), which exhibits >10,000-fold selectivity for P2Y14 over other P2Y receptors. PPTN inhibits UDP-glucose and MRS 2690-induced porcine pancreatic artery contraction ex vivo, and also blocks UDP-glucose-induced chemotaxis of HL-60 leukemia cells in vitro.
External Portal Information for PPTN hydrochloride
The Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PPTN is reviewed.
Compound Libraries for PPTN hydrochloride
PPTN hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for PPTN hydrochloride
| M. Wt | 511.96 |
| Formula | C29H24F3NO2.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1992047-65-0 |
| PubChem ID | 121513852 |
| InChI Key | FKMVYPCBLWYNAV-UHFFFAOYSA-N |
| Smiles | FC(F)(F)C(C=C4)=CC=C4C1=CC=C(C(C3=CC=C(C5CCNCC5)C=C3)=CC(C(O)=O)=C2)C2=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PPTN hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.2 | 100 | |
| ethanol | 10.24 | 20 |
Preparing Stock Solutions for PPTN hydrochloride
The following data is based on the product molecular weight 511.96. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.95 mL | 9.77 mL | 19.53 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.91 mL |
| 10 mM | 0.2 mL | 0.98 mL | 1.95 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.39 mL |
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Product Datasheets for PPTN hydrochloride
References for PPTN hydrochloride
References are publications that support the biological activity of the product.
Gao et al (2013) The role of P2Y14 and other P2Y receptors in degranulation of human LAD2 mast cells. Purinergic Signal. 9 31 PMID: 22825617
Alsaqati et al (2014) Novel vasocontractile role of the P2Y14 receptor: characterization of its signalling in porcine isolated pancreatic arteries. Br.J.Pharmacol. 171 701 PMID: 24138077
Barrett et al (2013) A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol.Pharmacol. 84 41 PMID: 23592514
If you know of a relevant reference for PPTN hydrochloride, please let us know.
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Keywords: PPTN hydrochloride, PPTN hydrochloride supplier, 1160271-30-6, high, affinity, selective, P2Y14, purinergics, receptor, antagonists, antagonises, inhibitors, inhibits, Purinergic, P2Y, Receptors, 4862, Tocris Bioscience
2 Citations for PPTN hydrochloride
Citations are publications that use Tocris products. Selected citations for PPTN hydrochloride include:
Dennis et al (2020) Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice. J Clin Invest 130 3734-3749 PMID: 32287042
Tilat A et al (2022) P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis. Elife 11 PMID: 35311647
Do you know of a great paper that uses PPTN hydrochloride from Tocris? Please let us know.
Reviews for PPTN hydrochloride
Average Rating: 4 (Based on 1 Review.)
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P2Y14 antagonist.
By
Anonymous on 09/20/2018
Assay Type: Ex Vivo
Species: Mouse
Incubation and during agonist treatment
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.