PPTN hydrochloride

Pricing Availability   Qty
Description: High affinity and selective P2Y14 antagonist
Chemical Name: 4-[4-(4-Piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (5)

Biological Activity for PPTN hydrochloride

PPTN hydrochloride is a high affinity and selective P2Y14 antagonist (KB = 434 pM), which exhibits >10,000-fold selectivity for P2Y14 over other P2Y receptors. PPTN inhibits UDP-glucose and MRS 2690-induced porcine pancreatic artery contraction ex vivo, and also blocks UDP-glucose-induced chemotaxis of HL-60 leukemia cells in vitro.

External Portal Information for PPTN hydrochloride

The Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PPTN is reviewed.

Compound Libraries for PPTN hydrochloride

PPTN hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PPTN hydrochloride

M. Wt 511.96
Formula C29H24F3NO2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1992047-65-0
PubChem ID 121513852
InChI Key FKMVYPCBLWYNAV-UHFFFAOYSA-N
Smiles FC(F)(F)C(C=C4)=CC=C4C1=CC=C(C(C3=CC=C(C5CCNCC5)C=C3)=CC(C(O)=O)=C2)C2=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PPTN hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.2 100
ethanol 10.24 20

Preparing Stock Solutions for PPTN hydrochloride

The following data is based on the product molecular weight 511.96. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.77 mL 19.53 mL
5 mM 0.39 mL 1.95 mL 3.91 mL
10 mM 0.2 mL 0.98 mL 1.95 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for PPTN hydrochloride

Certificate of Analysis / Product Datasheet
Select another batch:

References for PPTN hydrochloride

References are publications that support the biological activity of the product.

Gao et al (2013) The role of P2Y14 and other P2Y receptors in degranulation of human LAD2 mast cells. Purinergic Signal. 9 31 PMID: 22825617

Alsaqati et al (2014) Novel vasocontractile role of the P2Y14 receptor: characterization of its signalling in porcine isolated pancreatic arteries. Br.J.Pharmacol. 171 701 PMID: 24138077

Barrett et al (2013) A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol.Pharmacol. 84 41 PMID: 23592514


If you know of a relevant reference for PPTN hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Purinergic (P2Y) Receptor Antagonists

Keywords: PPTN hydrochloride, PPTN hydrochloride supplier, 1160271-30-6, high, affinity, selective, P2Y14, purinergics, receptor, antagonists, antagonises, inhibitors, inhibits, Purinergic, P2Y, Receptors, 4862, Tocris Bioscience

Citations for PPTN hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for PPTN hydrochloride. Do you know of a great paper that uses PPTN hydrochloride from Tocris? Please let us know.

Reviews for PPTN hydrochloride

Average Rating: 4 (Based on 1 Review.)

5 Star
0%
4 Star
100%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used PPTN hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


P2Y14 antagonist.
By Anonymous on 09/20/2018
Assay Type: Ex Vivo
Species: Mouse

Incubation and during agonist treatment


Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Pain Research Product Guide

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.

Cardiovascular Poster

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.