(+)-Clopidogrel hydrogen sulfate

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Cat.No. 1820 - (+)-Clopidogrel hydrogen sulfate | C16H16ClNO2S.H2SO4 | CAS No. 120202-66-6
Description: Selective P2Y12 antagonist
Alternative Names: Plavix
Chemical Name: (S)-(+)-Methyl 2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)-2-(2-chlorophenyl)acetate hydrogen sulfate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective, high affinity P2Y12 receptor antagonist. Inhibits ADP-induced platelet aggregation and displays antithrombotic activity. Active enantiomer of (±)-clopidogrel hydrochloride (Cat. No. 2490).

Technical Data

M. Wt 419.9
Formula C16H16ClNO2S.H2SO4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 120202-66-6
PubChem ID 115366
InChI Key FDEODCTUSIWGLK-RSAXXLAASA-N
Smiles OS(O)(=O)=O.COC(=O)[C@@H](N1CCC2=C(C1)C=CS2)C1=CC=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.99 100
water 41.99 100

Preparing Stock Solutions

The following data is based on the product molecular weight 419.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.91 mL 23.82 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kugelgen (2006) Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol.Ther. 110 415 PMID: 16257449

Reist et al (2000) Very low chiral inversion of clopidogrel in rats: a pharmacokinetic and mechanistic investigation. Drug Metab.Disp. 28 1405 PMID:

Savi et al (2001) P2Y12, a new platelet ADP receptor, target of clopidogrel. Biochem.Biophys.Res.Comm. 283 379 PMID:

Savi and Herbert (2005) Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Semin.Thromb.Haemostas. 31 174 PMID:


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