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(+)-Clopidogrel hydrogen sulfate
Selective, high affinity P2Y12 receptor antagonist. Inhibits ADP-induced platelet aggregation and displays antithrombotic activity. Active enantiomer of (±)-clopidogrel hydrochloride (Cat. No. 2490). Requires bioactivation.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 419.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.38 mL||11.91 mL||23.82 mL|
|5 mM||0.48 mL||2.38 mL||4.76 mL|
|10 mM||0.24 mL||1.19 mL||2.38 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References are publications that support the biological activity of the product.
Kugelgen (2006) Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol.Ther. 110 415 PMID: 16257449
Reist et al (2000) Very low chiral inversion of clopid. in rats: a pharmacokinetic and mechanistic investigation. Drug Metab.Disp. 28 1405
Savi et al (2001) P2Y12, a new platelet ADP receptor, target of clopid. Biochem.Biophys.Res.Comm. 283 379
Savi and Herbert (2005) Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Semin.Thromb.Haemostas. 31 174
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