2-Methylthioadenosine diphosphate trisodium salt

Pricing Availability   Qty
Description: Potent agonist at P2Y1, P2Y12 and P2Y13
Alternative Names: 2-(Methylthio)adenosine 5'-diphosphate, 2-Methylthio-ADP, MeSADP
Chemical Name: 2-(Methylthio)adenosine-5'-(trihydrogen diphosphate) trisodium salt
Purity: ≥98% (HPLC)
Citations (12)
Literature (1)

Biological Activity

2-Methylthioadenosine diphosphate trisodium salt is a potent purinergic agonist displaying selectivity for P2Y1, P2Y12 and P2Y13 receptors (pEC50 = 8.29 and 9.05 for P2Y1 and P2Y12, EC50 = 19 nM for P2Y13). Induces aggregation of, and inhibits cAMP accumulation in, platelets in vitro.

Technical Data

M. Wt 539.24
Formula C11H14N5Na3O10P2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 475193-31-8
PubChem ID 52942441
Smiles O[C@@H]1[C@@H](COP(OP([O-])([O-])=O)([O-])=O)O[C@@H](N3C2=NC(SC)=NC(N)=C2N=C3)[C@@H]1O.[Na+].[Na+].[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble in water (supplied pre-dissolved at a concentration of 10mM)

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Macfarlane et al (1983) 2-Methylthioadenosine[β-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. J.Clin.Invest. 71 420 PMID: 6298277

Sak and Webb (2002) A retrospective of recombinant P2Y receptor subtypes and their pharmacology. Arch.Biochem.Biophys. 397 131 PMID: 11747319

Zhang et al (2002) P2Y13: identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse. J.Pharmacol.Exp.Ther. 301 705 PMID: 11961076

If you know of a relevant reference for 2-Methylthioadenosine diphosphate trisodium salt, please let us know.

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View all Purinergic (P2Y) Receptor Agonists

Keywords: 2-Methylthioadenosine diphosphate trisodium salt, 2-Methylthioadenosine diphosphate trisodium salt supplier, Potent, agonists, P2Y1, P2Y12, P2Y13, Receptors, Purinergic, purinoceptors, p2yt, 2-methylthio-ADP, 2MeSADP, ME2SADP, 2-(Methylthio)adenosine, 5'-diphosphate, 2-Methylthio-ADP, MeSADP, P2Y, 1624, Tocris Bioscience

12 Citations for 2-Methylthioadenosine diphosphate trisodium salt

Citations are publications that use Tocris products. Selected citations for 2-Methylthioadenosine diphosphate trisodium salt include:

Zhang et al (2019) P2Y1 Purinergic Receptor Modulate Axon Initial Segment Initial Development. Front Cell Neurosci 13 152 PMID: 31068791

Manne et al (2018) PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway. J Thromb Haemost 16 1211 PMID: 29575487

Yamanaka et al (2012) A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ. PLoS One 7 e45032 PMID: 23056190

Ohtani et al (2008) Evidence for the possible involvement of the P2Y(6) receptor in Ca (2+) mobilization and Ins secretion in mouse pancreatic islets. Purinergic Signal 4 365 PMID: 18784987

Do you know of a great paper that uses 2-Methylthioadenosine diphosphate trisodium salt from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.