2-Methylthioadenosine diphosphate trisodium salt

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Description: Potent agonist at P2Y1, P2Y12 and P2Y13
Alternative Names: 2-(Methylthio)adenosine 5'-diphosphate,2-Methylthio-ADP,MeSADP
Chemical Name: 2-(Methylthio)adenosine-5'-(trihydrogen diphosphate) trisodium salt
Purity: ≥98% (HPLC)
Citations (12)
Literature (1)

Biological Activity

2-Methylthioadenosine diphosphate trisodium salt is a potent purinergic agonist displaying selectivity for P2Y1, P2Y12 and P2Y13 receptors (pEC50 = 8.29 and 9.05 for P2Y1 and P2Y12, EC50 = 19 nM for P2Y13). Induces aggregation of, and inhibits cAMP accumulation in, platelets in vitro.

Technical Data

M. Wt 539.24
Formula C11H14N5Na3O10P2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 475193-31-8
PubChem ID 52942441
Smiles O[C@@H]1[C@@H](COP(OP([O-])([O-])=O)([O-])=O)O[C@@H](N3C2=NC(SC)=NC(N)=C2N=C3)[C@@H]1O.[Na+].[Na+].[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble in water (supplied pre-dissolved at a concentration of 10mM)

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Macfarlane et al (1983) 2-Methylthioadenosine[β-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. J.Clin.Invest. 71 420 PMID: 6298277

Sak and Webb (2002) A retrospective of recombinant P2Y receptor subtypes and their pharmacology. Arch.Biochem.Biophys. 397 131 PMID: 11747319

Zhang et al (2002) P2Y13: identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse. J.Pharmacol.Exp.Ther. 301 705 PMID: 11961076

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View all Purinergic (P2Y) Receptor Agonists

Keywords: 2-Methylthioadenosine diphosphate trisodium salt, 2-Methylthioadenosine diphosphate trisodium salt supplier, Potent, agonists, P2Y1, P2Y12, P2Y13, Receptors, Purinergic, purinoceptors, p2yt, 2-methylthio-ADP, 2MeSADP, ME2SADP, 2-(Methylthio)adenosine, 5'-diphosphate, 2-Methylthio-ADP, MeSADP, P2Y, 1624, Tocris Bioscience

12 Citations for 2-Methylthioadenosine diphosphate trisodium salt

Citations are publications that use Tocris products. Selected citations for 2-Methylthioadenosine diphosphate trisodium salt include:

Manne et al (2018) PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway. J Thromb Haemost 16 1211 PMID: 29575487

Wang et al (2012) Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+. Nature 5 ra26 PMID: 22472648

Madry et al (2018) Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1. Neuron 97 299 PMID: 29290552

Lu et al (2018) The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration. Front Pharmacol 9 242 PMID: 29725296

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.