2-Methylthioadenosine diphosphate trisodium salt
Potent purinergic agonist displaying selectivity for P2Y1, P2Y12 and P2Y13 receptors (pEC50 = 8.29 and 9.05 for P2Y1 and P2Y12, EC50 = 19 nM for P2Y13). Induces aggregation of, and inhibits cAMP accumulation in, platelets in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble in water (supplied pre-dissolved at a concentration of 10mM)|
Preparing Stock Solutions
The following data is based on the product molecular weight 539.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.85 mL||9.27 mL||18.54 mL|
|5 mM||0.37 mL||1.85 mL||3.71 mL|
|10 mM||0.19 mL||0.93 mL||1.85 mL|
|50 mM||0.04 mL||0.19 mL||0.37 mL|
References are publications that support the products' biological activity.
Macfarlane et al (1983) 2-Methylthioadenosine[β-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. J.Clin.Invest. 71 420 PMID: 6298277
Sak and Webb (2002) A retrospective of recombinant P2Y receptor subtypes and their pharmacology. Arch.Biochem.Biophys. 397 131 PMID: 11747319
Zhang et al (2002) P2Y13: identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse. J.Pharmacol.Exp.Ther. 301 705 PMID: 11961076
If you know of a relevant reference for 2-Methylthioadenosine diphosphate trisodium salt, please let us know.
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Keywords: 2-Methylthioadenosine diphosphate trisodium salt, supplier, Potent, agonists, P2Y1, P2Y12, P2Y13, Receptors, Purinergic, purinoceptors, p2yt, 2-methylthio-ADP, 2MeSADP, ME2SADP, 2-(Methylthio)adenosine, 5'-diphosphate, 2-Methylthio-ADP, MeSADP, Purinergic, P2Y, Receptors, Purinergic, P2Y, Receptors, Tocris Bioscience
6 Citations for 2-Methylthioadenosine diphosphate trisodium salt
Citations are publications that use Tocris products. Selected citations for 2-Methylthioadenosine diphosphate trisodium salt include:
Zhang et al (2014) Agonist-bound structure of the human P2Y12 receptor. Purinergic Signal 509 119 PMID: 24784220
Voss et al (2014) The enteric nervous system of P2Y13 receptor null mice is resistant against high-fat-diet- and palmitic-acid-induced neuronal loss. Br J Pharmacol 10 455 PMID: 24510452
Ilatovskaya et al (2013) Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol 305 C1050 PMID: 24048730
Yamanaka et al (2012) A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ. PLoS One 7 e45032 PMID: 23056190
Wang et al (2012) Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+. Nature 5 ra26 PMID: 22472648
Ohtani et al (2008) Evidence for the possible involvement of the P2Y(6) receptor in Ca (2+) mobilization and insulin secretion in mouse pancreatic islets. Purinergic Signal 4 365 PMID: 18784987
Do you know of a great paper that uses 2-Methylthioadenosine diphosphate trisodium salt from Tocris? If so please let us know.
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