P2Y11 agonist (pEC50 = 6.27). Exhibits selectivity for P2Y11 over a range of P2Y and P2X receptors.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||11.81||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 1180.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||8.47 mL||42.35 mL||84.69 mL|
|0.5 mM||1.69 mL||8.47 mL||16.94 mL|
|1 mM||0.85 mL||4.23 mL||8.47 mL|
|5 mM||0.17 mL||0.85 mL||1.69 mL|
References are publications that support the biological activity of the product.
Meis et al (2010) NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-γ,γ'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleuk J.Pharmacol.Exp.Ther. 332 238 PMID: 19815812
If you know of a relevant reference for NF 546, please let us know.
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Keywords: NF 546, NF 546 supplier, NF546, p2y11, purinergic, receptors, agonists, Purinergic, P2Y, Receptors, 3892, Tocris Bioscience
2 Citations for NF 546
Citations are publications that use Tocris products. Selected citations for NF 546 include:
Gao et al (2013) The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Sci Adv 9 31 PMID: 22825617
Barragán-Iglesias et al (2014) Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells. Mol Pain 10 29 PMID: 24886406
Do you know of a great paper that uses NF 546 from Tocris? Please let us know.
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Literature in this Area
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