P2Y11 agonist (pEC50 = 6.27). Exhibits selectivity for P2Y11 over a range of P2Y and P2X receptors.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||11.81||10mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 1180.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.85 mL||4.23 mL||8.47 mL|
|5 mM||0.17 mL||0.85 mL||1.69 mL|
|10 mM||0.08 mL||0.42 mL||0.85 mL|
|50 mM||0.02 mL||0.08 mL||0.17 mL|
References are publications that support the products' biological activity.
Meis et al (2010) NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-γ,γ'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleuk J.Pharmacol.Exp.Ther. 332 238 PMID: 19815812
If you know of a relevant reference for NF 546, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: NF 546, supplier, NF546, p2y11, purinergic, receptors, agonists, Purinergic, P2Y, Receptors, Purinergic, P2Y, Receptors, Tocris Bioscience
2 Citations for NF 546
Citations are publications that use Tocris products. Selected citations for NF 546 include:
Barragán-Iglesias et al (2014) Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells. Mol Pain 10 29 PMID: 24886406
Gao et al (2013) The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Sci Adv 9 31 PMID: 22825617
Do you know of a great paper that uses NF 546 from Tocris? If so please let us know.
Reviews for NF 546
There are currently no reviews for this product. Be the first to review NF 546 and earn rewards!
Have you used NF 546?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.