NF 546

Pricing Availability Delivery Time Qty
Cat.No. 3892 - NF 546 | C47H44N6Na4O17P4 | CAS No. 1006028-37-0
Description: Selective P2Y11 agonist
Chemical Name: 4,4'-(Carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)carbonylimino))-bis(1,3-xylene-alpha,alpha'-diphosphonic acid tetrasodium salt
Purity: ≥95% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

P2Y11 agonist (pEC50 = 6.27). Exhibits selectivity for P2Y11 over a range of P2Y and P2X receptors.

Technical Data

M. Wt 1180.74
Formula C47H44N6Na4O17P4
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1006028-37-0
PubChem ID 73755075
InChI Key GSMUPMANKNAMAS-UHFFFAOYSA-J
Smiles [Na+].[Na+].[Na+].[Na+].CC1=CC=C(C=C1NC(=O)C1=CC=CC(NC(=O)NC2=CC=CC(=C2)C(=O)NC2=C(C)C=CC(=C2)C(=O)NC2=CC=C(CP(O)([O-])=O)C=C2CP(O)([O-])=O)=C1)C(=O)NC1=C(CP(O)([O-])=O)C=C(CP(O)([O-])=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 11.81 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 1180.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.85 mL 4.23 mL 8.47 mL
5 mM 0.17 mL 0.85 mL 1.69 mL
10 mM 0.08 mL 0.42 mL 0.85 mL
50 mM 0.02 mL 0.08 mL 0.17 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Meis et al (2010) NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-γ,γ'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleuk J.Pharmacol.Exp.Ther. 332 238 PMID: 19815812


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Keywords: NF546 p2y11 purinergic receptors agonists Purinergic P2Y Receptors

2 Citations for NF 546

Citations are publications that use Tocris products. Selected citations for NF 546 include:

Barragán-Iglesias et al (2014) Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells. Mol Pain 10 29 PMID: 24886406

Gao et al (2013) The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Sci Adv 9 31 PMID: 22825617


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P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.

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Pathways for NF 546

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