NF 546

Pricing Availability   Qty
Cat.No. 3892 - NF 546 | C47H44N6Na4O17P4 | CAS No. 1006028-37-0
Description: Selective P2Y11 agonist
Chemical Name: 4,4'-(Carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)carbonylimino))-bis(1,3-xylene-alpha,alpha'-diphosphonic acid tetrasodium salt
Purity: ≥95% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

P2Y11 agonist (pEC50 = 6.27). Exhibits selectivity for P2Y11 over a range of P2Y and P2X receptors.

Technical Data

M. Wt 1180.74
Formula C47H44N6Na4O17P4
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1006028-37-0
PubChem ID 73755075
InChI Key GSMUPMANKNAMAS-UHFFFAOYSA-J
Smiles [Na+].[Na+].[Na+].[Na+].CC1=CC=C(C=C1NC(=O)C1=CC=CC(NC(=O)NC2=CC=CC(=C2)C(=O)NC2=C(C)C=CC(=C2)C(=O)NC2=CC=C(CP(O)([O-])=O)C=C2CP(O)([O-])=O)=C1)C(=O)NC1=C(CP(O)([O-])=O)C=C(CP(O)([O-])=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 11.81 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 1180.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 8.47 mL 42.35 mL 84.69 mL
0.5 mM 1.69 mL 8.47 mL 16.94 mL
1 mM 0.85 mL 4.23 mL 8.47 mL
5 mM 0.17 mL 0.85 mL 1.69 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Meis et al (2010) NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-γ,γ'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleuk J.Pharmacol.Exp.Ther. 332 238 PMID: 19815812


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Keywords: NF 546, NF 546 supplier, NF546, p2y11, purinergic, receptors, agonists, Purinergic, P2Y, Receptors, 3892, Tocris Bioscience

2 Citations for NF 546

Citations are publications that use Tocris products. Selected citations for NF 546 include:

Gao et al (2013) The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Sci Adv 9 31 PMID: 22825617

Barragán-Iglesias et al (2014) Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells. Mol Pain 10 29 PMID: 24886406


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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