Irreversible P2Y12 antagonist; metabolised to active metabolite R-99224 (IC50 = 45 μM) irreversibly binds platelet P2Y12 receptors, inhibiting platelet activation. Antiplatelet and antithrombotic. Orally active and active in vivo. Note - inactive in vitro.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 373.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.68 mL||13.39 mL||26.78 mL|
|5 mM||0.54 mL||2.68 mL||5.36 mL|
|10 mM||0.27 mL||1.34 mL||2.68 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
References are publications that support the biological activity of the product.
Sugidachi et al (2000) The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties. Br.J.Pharmacol. 129 1439 PMID: 10742300
Hashimoto (2007) The influence of P2Y12 receptor deficiency on the platelet inhibitory activities of prasugrel in a mouse model: evidence for specific inhibition of P2Y12 receptors by prasugrel. Biochem.Pharmacol. 74 1003 PMID: 17681285
Huber et al (2009) Prasugrel. Nat.Rev.Drug Discov. 8 449 PMID: 19483707
If you know of a relevant reference for Prasugrel, please let us know.
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Keywords: Prasugrel, Prasugrel supplier, LY640315, Prasugrel, P2Y12, purinergic, antagonists, receptors, purinoceptors, adenosine, CS_747, CS747, Effient, Efient, antiplatelet, atherosclerosis, antithromboembolic, orally, active, in, vivo, CS, 747, Purinergic, P2Y, Receptors, 6317, Tocris Bioscience
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