Pricing Availability   Qty
Description: Irreversible P2Y12 antagonist; antiplatelet and orally active
Alternative Names: LY640315,CS 747,Effient
Chemical Name: 2-[2-(Acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)ethanone
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for Prasugrel

Prasugrel is an irreversible P2Y12 antagonist; metabolised to active metabolite R-99224 (IC50 = 45 μM) irreversibly binds platelet P2Y12 receptors, inhibiting platelet activation. Antiplatelet and antithrombotic. Orally active and active in vivo. Note - inactive in vitro.

Compound Libraries for Prasugrel

Prasugrel is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Prasugrel

M. Wt 373.44
Formula C20H20FNO3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 150322-43-3
PubChem ID 6918456
Smiles CC(OC1=CC2=C(S1)CCN(C(C3=C(C=CC=C3)F)C(C4CC4)=O)C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Prasugrel

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 37.34 100

Preparing Stock Solutions for Prasugrel

The following data is based on the product molecular weight 373.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.39 mL 26.78 mL
5 mM 0.54 mL 2.68 mL 5.36 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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References for Prasugrel

References are publications that support the biological activity of the product.

Sugidachi et al (2000) The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties. Br.J.Pharmacol. 129 1439 PMID: 10742300

Hashimoto (2007) The influence of P2Y12 receptor deficiency on the platelet inhibitory activities of pras. in a mouse model: evidence for specific inhibition of P2Y12 receptors by pras. Biochem.Pharmacol. 74 1003 PMID: 17681285

Huber et al (2009) Prasugrel. Nat.Rev.Drug Discov. 8 449 PMID: 19483707

If you know of a relevant reference for Prasugrel, please let us know.

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Citations for Prasugrel

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.