P2X and P2Y Receptors Scientific Review

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P2X and P2Y Receptors Scientific Review

Kenneth A. Jacobson, National Institutes of Health

Review excerpt: "The P2 receptors for extracellular nucleotides are widely distributed in the body and participate in regulation of nearly every physiological process. Of particular interest are nucleotide receptors in the immune, inflammatory, cardiovascular, muscular, and central and peripheral nervous systems. The ubiquitous signaling properties of extracellular nucleotides acting at two distinct families of P2 receptors - fast P2X ion channels and P2Y receptors (G-protein-coupled receptors) - are now well recognized."