Nucleoside Transporters

Nucleoside transporters are divided into two families: the Na+-dependent solute carrier family 28 (SLC28) and the equilibrative solute carrier family 29 (SLC29). SLC28 family transporters (CNT1, 2 and 3) display subtype-selective tissue expression patterns.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
4588 8MDP
Potent equilibrative nucleoside transporter (ENT) inhibitor
1692 Cilostazol
Adenosine uptake inhibitor. Also PDE3A inhibitor
4722 Decynium 22
PMAT inhibitor
0481 Dilazep dihydrochloride
Adenosine uptake inhibitor
0691 Dipyridamole
Adenosine transport inhibitor
1745 5-Iodotubercidin
Nucleoside transporter inhibitor; also a broad spectrum kinase inhibitor
2924 NBMPR
Equilibrative nucleoside transporter 1 (ENT1) inhibitor
5100 TC-T 6000
Potent equilibrative nucleoside transporter 4 (ENT4) inhibitor

Nucleoside transporters are divided into two families: the Na+-dependent solute carrier family 28 (SLC28) and the equilibrative solute carrier family 29 (SLC29). SLC28 family transporters (CNT1-3) display subtype-selective expression patterns; CNT1 is localized primarily to epithelial tissue whereas CNT2 and CNT3 have more widespread distributions.

SLC29 family transporters (ENT1-4) are glycosylated proteins, localized to the plasma and mitochondrial membranes. They are expressed in the heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen. They mediate nucleoside influx and efflux and exhibit highest affinity for adenosine.

CNT and ENT transporters play critical roles in nucleoside salvage pathways where they mediate the first step of nucleotide biosynthesis. In addition, these transporters work in concert to terminate adenosine signaling and are vital determinants in the response to a variety of cancer and antiviral treatments, as they modulate the entry of these nucleoside analogs into target tissues.

External sources of pharmacological information for Nucleoside Transporters :

    Literature for Nucleoside Transporters

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    • 7-TM Receptors
    • Enzymes
    • Enzyme-Linked Receptors
    • Ion Channels
    • Nuclear Receptors
    • Transporters
    • Apoptosis
    • Cell Metabolism
    • Epigenetics
    • Fluorescent Imaging
    • Signal Transduction
    • Stem Cells

    Nucleoside Transporter Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    CNT1 Human SLC28A1 NM_201651 O00337
    Mouse Slc28a1 NM_001004184 NP_001004184
    Rat Slc28a1 NM_053863 Q62674
    CNT2 Human SLC28A2 NM_004212 O43868
    Mouse Slc28a2 NM_172980 O88627
    Rat Slc28a2 NM_031664 Q62773
    CNT3 Human SLC28A3 NM_022127 Q9HAS3
    Mouse Slc28a3 NM_022317 Q9ERH8
    Rat Slc28a3 NM_080908 Q8VIH3
    ENT1 Human SLC29A1 NM_001078174 Q99808
    Mouse Slc29a1 NM_022880 Q9JIM1
    Rat Slc29a1 NM_031684 O54698
    ENT2 Human SLC29A2 NM_001532 Q14542
    Mouse Slc29a2 NM_007854 Q61672
    Rat Slc29a2 NM_031738 O54699
    ENT3 Human SLC29A3 NM_018344 Q9BZD2
    Mouse Slc29a3 NM_023596 Q99P65
    Rat Slc29a3 NM_181639 Q6AZ86
    ENT4 Human SLC29A4 NM_153247 Q7RTT9
    Mouse Slc29a4 NM_146257 Q8R139
    Rat Slc29a4 NM_001105911 XP_221940