(±)-Clopidogrel hydrochloride

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Cat.No. 2490 - (±)-Clopidogrel hydrochloride | C16H16NO2SCl.HCl | CAS No. 130209-90-4
Description: Selective P2Y12 antagonist
Alternative Names: Plavix
Chemical Name: Methyl 2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)-2-(2-chlorophenyl)acetate hydrochloride
Purity: ≥99% (HPLC)

Biological Activity

Selective, high affinity P2Y12 receptor antagonist (pKi = 6.9 for hP2Y12 receptor). Inhibits ADP-induced platelet aggregation; potent antithrombotic agent. Requires bioactivation, unlike PSB 0739.

Active Enantiomer also available.

Technical Data

M. Wt 358.28
Formula C16H16NO2SCl.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 130209-90-4
PubChem ID 22386150
Smiles Cl.COC(=O)C(N1CCC2=C(C1)C=CS2)C1=C(Cl)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.83 100
ethanol 35.83 100

Preparing Stock Solutions

The following data is based on the product molecular weight 358.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.79 mL 13.96 mL 27.91 mL
5 mM 0.56 mL 2.79 mL 5.58 mL
10 mM 0.28 mL 1.4 mL 2.79 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Kugelgen (2006) Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol.Ther. 110 415 PMID: 16257449

Savi et al (2001) P2Y12, a new platelet ADP receptor, target of clopidogrel. Biochem.Biophys.Res.Comm. 283 379 PMID:

Savi and Herbert (2005) Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Semin.Thromb.Haemostas. 31 174 PMID:

If you know of a relevant reference for (±)-Clopidogrel hydrochloride, please let us know.

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Keywords: (±)-Clopidogrel hydrochloride, supplier, Selective, P2Y12, antagonists, Receptors, Purinergic, purinoceptors, p2yt, Plavix, Purinergic, P2Y, Receptors, Purinergic, P2Y, Receptors, Tocris Bioscience

Citations for (±)-Clopidogrel hydrochloride

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