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Biological Activity for (±)-Clopidogrel hydrochloride
(±)-Clopidogrel hydrochloride is a selective, high affinity P2Y12 receptor antagonist (pKi = 6.9 for hP2Y12 receptor). Inhibits ADP-induced platelet aggregation; potent antithrombotic agent. Requires bioactivation, unlike PSB 0739.
Active Enantiomer also available.
Technical Data for (±)-Clopidogrel hydrochloride
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (±)-Clopidogrel hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for (±)-Clopidogrel hydrochloride
The following data is based on the product molecular weight 358.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.79 mL||13.96 mL||27.91 mL|
|5 mM||0.56 mL||2.79 mL||5.58 mL|
|10 mM||0.28 mL||1.4 mL||2.79 mL|
|50 mM||0.06 mL||0.28 mL||0.56 mL|
Product Datasheets for (±)-Clopidogrel hydrochloride
References for (±)-Clopidogrel hydrochloride
References are publications that support the biological activity of the product.
Kugelgen (2006) Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol.Ther. 110 415 PMID: 16257449
Savi et al (2001) P2Y12, a new platelet ADP receptor, target of clopid. Biochem.Biophys.Res.Comm. 283 379
Savi and Herbert (2005) Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Semin.Thromb.Haemostas. 31 174
If you know of a relevant reference for (±)-Clopidogrel hydrochloride, please let us know.
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Keywords: (±)-Clopidogrel hydrochloride, (±)-Clopidogrel hydrochloride supplier, Selective, P2Y12, antagonists, Receptors, Purinergic, purinoceptors, p2yt, antagonises, inhibitors, inhibits, Plavix, P2Y, 2490, Tocris Bioscience
Citations for (±)-Clopidogrel hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for (±)-Clopidogrel hydrochloride. Do you know of a great paper that uses (±)-Clopidogrel hydrochloride from Tocris? Please let us know.
Reviews for (±)-Clopidogrel hydrochloride
Average Rating: 4 (Based on 1 Review.)
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incubation and during assay
Literature in this Area
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