(±)-Clopidogrel hydrochloride

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Cat.No. 2490 - (±)-Clopidogrel hydrochloride | C16H16NO2SCl.HCl | CAS No. 130209-90-4
Description: Selective P2Y12 antagonist
Alternative Names: Plavix
Chemical Name: Methyl 2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)-2-(2-chlorophenyl)acetate hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews (1)
Literature

Biological Activity

Selective, high affinity P2Y12 receptor antagonist (pKi = 6.9 for hP2Y12 receptor). Inhibits ADP-induced platelet aggregation; potent antithrombotic agent. Requires bioactivation, unlike PSB 0739.

Active Enantiomer also available.

Technical Data

M. Wt 358.28
Formula C16H16NO2SCl.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 130209-90-4
PubChem ID 22386150
InChI Key XIHVAFJSGWDBGA-UHFFFAOYSA-N
Smiles Cl.COC(=O)C(N1CCC2=C(C1)C=CS2)C1=C(Cl)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.83 100
ethanol 35.83 100

Preparing Stock Solutions

The following data is based on the product molecular weight 358.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.79 mL 13.96 mL 27.91 mL
5 mM 0.56 mL 2.79 mL 5.58 mL
10 mM 0.28 mL 1.4 mL 2.79 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Kugelgen (2006) Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol.Ther. 110 415 PMID: 16257449

Savi et al (2001) P2Y12, a new platelet ADP receptor, target of clopid. Biochem.Biophys.Res.Comm. 283 379

Savi and Herbert (2005) Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Semin.Thromb.Haemostas. 31 174


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Keywords: (±)-Clopidogrel hydrochloride, (±)-Clopidogrel hydrochloride supplier, Selective, P2Y12, antagonists, Receptors, Purinergic, purinoceptors, p2yt, Plavix, P2Y, 2490, Tocris Bioscience

Citations for (±)-Clopidogrel hydrochloride

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Reviews for (±)-Clopidogrel hydrochloride

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P2Y12 antagonist.
By Anonymous on 09/20/2018
Species: Human

incubation and during assay


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