MRS 2211

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Description: Competitive P2Y13 antagonist
Chemical Name: 2-[(2-Chloro-5-nitrophenyl)azo]-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde disodium salt
Purity: ≥96% (HPLC)
Citations (10)
Literature (1)

Biological Activity for MRS 2211

MRS 2211 is a competitive P2Y13 receptor antagonist (pIC50 = 5.97) that displays > 20-fold selectivity over P2Y1 and P2Y12 receptors.

Technical Data for MRS 2211

M. Wt 474.66
Formula C14H10N4O8Na2PCl
Storage Desiccate at -20°C
Purity ≥96% (HPLC)
PubChem ID 57369297
Smiles [Na+].[Na+].CC1=C(O)C(C=O)=C(COP([O-])([O-])=O)C(\N=N\C2=C(Cl)C=CC(=C2)[N+]([O-])=O)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MRS 2211

Solvent Max Conc. mg/mL Max Conc. mM
water 33.23 70

Preparing Stock Solutions for MRS 2211

The following data is based on the product molecular weight 474.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.7 mM 3.01 mL 15.05 mL 30.1 mL
3.5 mM 0.6 mL 3.01 mL 6.02 mL
7 mM 0.3 mL 1.5 mL 3.01 mL
35 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets for MRS 2211

Certificate of Analysis / Product Datasheet
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References for MRS 2211

References are publications that support the biological activity of the product.

Kim et al (2005) Synthesis of pyridoxal phosphate derivatives with antagonist activity at the P2Y13 receptor. Biochem.Pharmacol. 70 266 PMID: 15913566

Kugelgen (2006) Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol.Ther. 110 415 PMID: 16257449

If you know of a relevant reference for MRS 2211, please let us know.

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Keywords: MRS 2211, MRS 2211 supplier, Competitive, P2Y13, antagonists, Receptors, Purinergic, purinoceptors, MRS2211, 219554-11-7, antagonises, inhibitors, inhibits, P2Y, 2402, Tocris Bioscience

10 Citations for MRS 2211

Citations are publications that use Tocris products. Selected citations for MRS 2211 include:

Puerto et al (2012) Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation. J Cell Sci 125 176 PMID: 22250198

Balduini et al (2012) Constitutively released adenosine diphosphate regulates proplatelet formation by human megakaryocytes. Haematologica 97 1657 PMID: 22689668

Madry et al (2018) Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1. Neuron 97 299 PMID: 29290552

Wang et al (2014) Nucleolin down-regulation is involved in ADP-induced cell cycle arrest in S phase and cell apoptosis in vascular endothelial cells. PLoS One 9 e110101 PMID: 25290311

Do you know of a great paper that uses MRS 2211 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.