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2-Methylthioadenosine triphosphate tetrasodium salt
2-Methylthioadenosine triphosphate tetrasodium salt is a P2 purinoceptor agonist.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble in water (supplied pre-dissolved at a concentration of 10mM)|
References are publications that support the biological activity of the product.
Burnstock et al (1983) Studies on the stereoselectivity of the P2-purinoreceptor. Br.J.Pharmacol. 79 907 PMID: 6317121
Cusack et al (1982) Specific but non-competitive inhibition by 2-alkylthioanalogues of adenosine 5'-monophosphate and adenosine 5'-triphosphate of human platelet aggregation induced by adenosine 5'-diphosphate. Br.J.Pharmacol. 75 397 PMID: 7186826
Khakh et al (2001) International Union of Pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits. Pharmacol.Rev. 53 107 PMID: 11171941
McMurray et al (1998) Purinoceptor subtypes mediating contraction and relaxation of marmoset urinary bladder smooth muscle. Br.J.Pharmacol. 123 1579 PMID: 9605564
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Keywords: 2-Methylthioadenosine triphosphate tetrasodium salt, 2-Methylthioadenosine triphosphate tetrasodium salt supplier, P2, purinergic, agonists, P2X, Receptors, Purinergic, P2Y, purinoceptors, 2-Methylthio-ATP, 1062, Tocris Bioscience
3 Citations for 2-Methylthioadenosine triphosphate tetrasodium salt
Citations are publications that use Tocris products. Selected citations for 2-Methylthioadenosine triphosphate tetrasodium salt include:
Nagai et al (2017) Antihypertrophic Effects of Small Molecules that Maintain Mitochondrial ATP Levels Under Hypoxia. EBioMedicine 24 147 PMID: 28942281
Zhang et al (2014) Agonist-bound structure of the human P2Y12 receptor. Med J Islam Repub Iran 509 119 PMID: 24784220
Rahbar et al (2016) Purinergic and Cholinergic Drugs Mediate Hyperventilation in Zebrafish: Evidence from a Novel Chemical Screen. Nature 11 e0154261 PMID: 27100625
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.