2-Methylthioadenosine triphosphate tetrasodium salt
P2 purinoceptor agonist.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 641.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.56 mL||7.8 mL||15.6 mL|
|5 mM||0.31 mL||1.56 mL||3.12 mL|
|10 mM||0.16 mL||0.78 mL||1.56 mL|
|50 mM||0.03 mL||0.16 mL||0.31 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Burnstock et al (1983) Studies on the stereoselectivity of the P2-purinoreceptor. Br.J.Pharmacol. 79 907 PMID: 6317121
Cusack et al (1982) Specific but non-competitive inhibition by 2-alkylthioanalogues of adenosine 5'-monophosphate and adenosine 5'-triphosphate of human platelet aggregation induced by adenosine 5'-diphosphate. Br.J.Pharmacol. 75 397 PMID: 7186826
Khakh et al (2001) International Union of Pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits. Pharmacol.Rev. 53 107 PMID: 11171941
McMurray et al (1998) Purinoceptor subtypes mediating contraction and relaxation of marmoset urinary bladder smooth muscle. Br.J.Pharmacol. 123 1579 PMID: 9605564
If you know of a relevant reference for 2-Methylthioadenosine triphosphate tetrasodium salt, please let us know.
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Keywords: 2-Methylthioadenosine triphosphate tetrasodium salt, supplier, P2, purinergic, agonists, P2X, Receptors, Purinergic, P2Y, purinoceptors, 2-Methylthio-ATP, P2X, Receptors, Tocris Bioscience
2 Citations for 2-Methylthioadenosine triphosphate tetrasodium salt
Citations are publications that use Tocris products. Selected citations for 2-Methylthioadenosine triphosphate tetrasodium salt include:
Rahbar et al (2016) Purinergic and Cholinergic Drugs Mediate Hyperventilation in Zebrafish: Evidence from a Novel Chemical Screen. Nature 11 e0154261 PMID: 27100625
Zhang et al (2014) Agonist-bound structure of the human P2Y12 receptor. Med J Islam Repub Iran 509 119 PMID: 24784220
Do you know of a great paper that uses 2-Methylthioadenosine triphosphate tetrasodium salt from Tocris? If so please let us know.
Literature in this Area
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.