2-Methylthioadenosine triphosphate tetrasodium salt

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Cat.No. 1062 - 2-Methylthioadenosine triphosphate tetrasodium salt | C11H14N5Na4O13P3S | CAS No. 100020-57-3
Description: P2 purinergic agonist
Alternative Names: 2-Methylthio-ATP
Chemical Name: 2-Methylthioadenosine-5'-triphosphate tetrasodium salt
Datasheet
Citations (2)
Literature

Biological Activity

P2 purinoceptor agonist.

Technical Data

M. Wt 641.2
Formula C11H14N5Na4O13P3S
Storage Desiccate at -20°C
CAS Number 100020-57-3
PubChem ID 16218831
InChI Key UEEFBRHXFDJPTA-KWIZKVQNSA-J
Smiles NC1=C2C(N([C@@H]3O[C@H](COP(OP(OP([O-])([O-])=O)([O-])=O)([O-])=O)[C@@H](O)[C@H]3O)C=N2)=NC(SC)=N1.[Na+].[Na+].[Na+].[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 64.12 100

Preparing Stock Solutions

The following data is based on the product molecular weight 641.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.56 mL 7.8 mL 15.6 mL
5 mM 0.31 mL 1.56 mL 3.12 mL
10 mM 0.16 mL 0.78 mL 1.56 mL
50 mM 0.03 mL 0.16 mL 0.31 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Burnstock et al (1983) Studies on the stereoselectivity of the P2-purinoreceptor. Br.J.Pharmacol. 79 907 PMID: 6317121

Cusack et al (1982) Specific but non-competitive inhibition by 2-alkylthioanalogues of adenosine 5'-monophosphate and adenosine 5'-triphosphate of human platelet aggregation induced by adenosine 5'-diphosphate. Br.J.Pharmacol. 75 397 PMID: 7186826

Khakh et al (2001) International Union of Pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits. Pharmacol.Rev. 53 107 PMID: 11171941

McMurray et al (1998) Purinoceptor subtypes mediating contraction and relaxation of marmoset urinary bladder smooth muscle. Br.J.Pharmacol. 123 1579 PMID: 9605564


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Keywords: 2-Methylthioadenosine triphosphate tetrasodium salt, supplier, P2, purinergic, agonists, P2X, Receptors, Purinergic, P2Y, purinoceptors, 2-Methylthio-ATP, P2X, Receptors, Purinergic, P2Y, Receptors, P2X, Receptors, Tocris Bioscience

2 Citations for 2-Methylthioadenosine triphosphate tetrasodium salt

Citations are publications that use Tocris products. Selected citations for 2-Methylthioadenosine triphosphate tetrasodium salt include:

Zhang et al (2014) Agonist-bound structure of the human P2Y12 receptor. Med J Islam Repub Iran 509 119 PMID: 24784220

Rahbar et al (2016) Purinergic and Cholinergic Drugs Mediate Hyperventilation in Zebrafish: Evidence from a Novel Chemical Screen. Nature 11 e0154261 PMID: 27100625


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