2-ThioUTP tetrasodium salt

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Cat.No. 3280 - 2-ThioUTP tetrasodium salt | C9H11N2Na4O14P3S | CAS No. 1343364-70-4
Description: Potent and selective P2Y2 agonist
Chemical Name: 2-Thiouridine 5'-triphosphate tetrasodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Potent and selective P2Y2 agonist (EC50 values are 0.035, 0.35 and 1.5 μM for hP2Y2, hP2Y4 and hP2Y6 receptors respectively).

Technical Data

M. Wt 588.13
Formula C9H11N2Na4O14P3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1343364-70-4
PubChem ID 54591573
InChI Key QCBCNKBBEOQRRB-ODQFIEKDSA-J
Smiles [Na+].[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)N1C=CC(=O)NC1=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble in water (supplied pre-dissolved at a concentration of 10mM)

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

El-Tayeb et al (2006) Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4 and P2Y6 receptors. J.Med.Chem. 49 7076 PMID: 17125260

Ko et al (2008) Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. Bioorg.Med.Chem. 16 6319 PMID: 18514530


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Keywords: 2-ThioUTP tetrasodium salt, 2-ThioUTP tetrasodium salt supplier, Potent, selective, P2Y2, agonists, Receptors, Purinergic, purinoceptors, P2Y, 3280, Tocris Bioscience

3 Citations for 2-ThioUTP tetrasodium salt

Citations are publications that use Tocris products. Selected citations for 2-ThioUTP tetrasodium salt include:

Martín-Gil et al (2012) Silencing of P2Y(2) receptors reduces intraocular pressure in New Zealand rabbits. Br J Pharmacol 165 1163 PMID: 21740413

Alkhani et al (2014) Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors. Mol Brain 10 43 PMID: 24965271

Matsumoto et al (2011) Uridine adenosine tetraphosphate-induced contraction is increased in renal but not pulmonary arteries from DOCA-salt hypertensive rats. Am J Physiol Heart Circ Physiol 301 H409 PMID: 21551273


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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