2-ThioUTP tetrasodium salt

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Cat.No. 3280 - 2-ThioUTP tetrasodium salt | C9H11N2Na4O14P3S | CAS No. 1343364-70-4
Description: Potent and selective P2Y2 agonist
Chemical Name: 2-Thiouridine 5'-triphosphate tetrasodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Potent and selective P2Y2 agonist (EC50 values are 0.035, 0.35 and 1.5 μM for hP2Y2, hP2Y4 and hP2Y6 receptors respectively).

Technical Data

M. Wt 588.13
Formula C9H11N2Na4O14P3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1343364-70-4
PubChem ID 54591573
InChI Key QCBCNKBBEOQRRB-ODQFIEKDSA-J
Smiles [Na+].[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)N1C=CC(=O)NC1=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in water (supplied pre-dissolved at a concentration of 10mM)

Preparing Stock Solutions

The following data is based on the product molecular weight 588.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.7 mL 8.5 mL 17 mL
5 mM 0.34 mL 1.7 mL 3.4 mL
10 mM 0.17 mL 0.85 mL 1.7 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

El-Tayeb et al (2006) Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4 and P2Y6 receptors. J.Med.Chem. 49 7076 PMID: 17125260

Ko et al (2008) Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. Bioorg.Med.Chem. 16 6319 PMID: 18514530


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Keywords: 2-ThioUTP tetrasodium salt, supplier, Potent, selective, P2Y2, agonists, Receptors, Purinergic, purinoceptors, Purinergic, P2Y, Receptors, Tocris Bioscience

3 Citations for 2-ThioUTP tetrasodium salt

Citations are publications that use Tocris products. Selected citations for 2-ThioUTP tetrasodium salt include:

Martín-Gil et al (2012) Silencing of P2Y(2) receptors reduces intraocular pressure in New Zealand rabbits. Br J Pharmacol 165 1163 PMID: 21740413

Matsumoto et al (2011) Uridine adenosine tetraphosphate-induced contraction is increased in renal but not pulmonary arteries from DOCA-salt hypertensive rats. Am J Physiol Heart Circ Physiol 301 H409 PMID: 21551273

Alkhani et al (2014) Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors. Mol Brain 10 43 PMID: 24965271


Do you know of a great paper that uses 2-ThioUTP tetrasodium salt from Tocris? If so please let us know.

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