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2-ThioUTP tetrasodium salt
Biological Activity for 2-ThioUTP tetrasodium salt
2-ThioUTP tetrasodium salt is a potent and selective P2Y2 agonist (EC50 values are 0.035, 0.35 and 1.5 μM for hP2Y2, hP2Y4 and hP2Y6 receptors respectively).
Technical Data for 2-ThioUTP tetrasodium salt
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 2-ThioUTP tetrasodium salt
|Solubility||Soluble in water (supplied pre-dissolved at a concentration of 10mM)|
Product Datasheets for 2-ThioUTP tetrasodium salt
References for 2-ThioUTP tetrasodium salt
References are publications that support the biological activity of the product.
El-Tayeb et al (2006) Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4 and P2Y6 receptors. J.Med.Chem. 49 7076 PMID: 17125260
Ko et al (2008) Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. Bioorg.Med.Chem. 16 6319 PMID: 18514530
If you know of a relevant reference for 2-ThioUTP tetrasodium salt, please let us know.
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Keywords: 2-ThioUTP tetrasodium salt, 2-ThioUTP tetrasodium salt supplier, Potent, selective, P2Y2, agonists, Receptors, Purinergic, purinoceptors, P2Y, 3280, Tocris Bioscience
3 Citations for 2-ThioUTP tetrasodium salt
Citations are publications that use Tocris products. Selected citations for 2-ThioUTP tetrasodium salt include:
Martín-Gil et al (2012) Silencing of P2Y(2) receptors reduces intraocular pressure in New Zealand rabbits. Br J Pharmacol 165 1163 PMID: 21740413
Alkhani et al (2014) Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors. Mol Brain 10 43 PMID: 24965271
Matsumoto et al (2011) Uridine adenosine tetraphosphate-induced contraction is increased in renal but not pulmonary arteries from DOCA-salt hypertensive rats. Am J Physiol Heart Circ Physiol 301 H409 PMID: 21551273
Do you know of a great paper that uses 2-ThioUTP tetrasodium salt from Tocris? Please let us know.
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Literature in this Area
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