2-ThioUTP tetrasodium salt

Pricing Availability   Qty
Description: Potent and selective P2Y2 agonist
Chemical Name: 2-Thiouridine 5'-triphosphate tetrasodium salt
Purity: ≥95% (HPLC)
Citations (3)
Literature (1)

Biological Activity for 2-ThioUTP tetrasodium salt

2-ThioUTP tetrasodium salt is a potent and selective P2Y2 agonist (EC50 values are 0.035, 0.35 and 1.5 μM for hP2Y2, hP2Y4 and hP2Y6 receptors respectively).

Technical Data for 2-ThioUTP tetrasodium salt

M. Wt 588.13
Formula C9H11N2Na4O14P3S
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1343364-70-4
PubChem ID 54591573
Smiles [Na+].[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)N1C=CC(=O)NC1=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 2-ThioUTP tetrasodium salt

Solubility Soluble in water (supplied pre-dissolved at a concentration of 10mM)

Product Datasheets for 2-ThioUTP tetrasodium salt

Certificate of Analysis / Product Datasheet
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References for 2-ThioUTP tetrasodium salt

References are publications that support the biological activity of the product.

El-Tayeb et al (2006) Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4 and P2Y6 receptors. J.Med.Chem. 49 7076 PMID: 17125260

Ko et al (2008) Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. Bioorg.Med.Chem. 16 6319 PMID: 18514530

If you know of a relevant reference for 2-ThioUTP tetrasodium salt, please let us know.

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Keywords: 2-ThioUTP tetrasodium salt, 2-ThioUTP tetrasodium salt supplier, Potent, selective, P2Y2, agonists, Receptors, Purinergic, purinoceptors, P2Y, 3280, Tocris Bioscience

3 Citations for 2-ThioUTP tetrasodium salt

Citations are publications that use Tocris products. Selected citations for 2-ThioUTP tetrasodium salt include:

Alkhani et al (2014) Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors. Mol Brain 10 43 PMID: 24965271

Matsumoto et al (2011) Uridine adenosine tetraphosphate-induced contraction is increased in renal but not pulmonary arteries from DOCA-salt hypertensive rats. Am J Physiol Heart Circ Physiol 301 H409 PMID: 21551273

Martín-Gil et al (2012) Silencing of P2Y(2) receptors reduces intraocular pressure in New Zealand rabbits. Br J Pharmacol 165 1163 PMID: 21740413

Do you know of a great paper that uses 2-ThioUTP tetrasodium salt from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.