MRS 2690

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Cat.No. 2915 - MRS 2690 | C15H22N2Na2O16P2S | CAS No. 15039-58-4
Description: Potent P2Y14 agonist
Chemical Name: Diphosphoric acid 1-α-D-glucopyranosyl ester 2-[(4'-methylthio)uridin-5''-yl] ester disodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Literature

Biological Activity

Potent P2Y14 receptor agonist (EC50 = 49 nM) that displays 7-fold higher potency than UDP-glucose.

Technical Data

M. Wt 626.33
Formula C15H22N2Na2O16P2S
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 15039-58-4
PubChem ID 73755042
InChI Key TYVFMVSNSGMZPA-QBNUFUENSA-L
Smiles [Na+].[Na+].OC[C@H]1O[C@H](OP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=CC(=O)NC2=S)[C@H](O)[C@@H](O)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 62.63 100

Preparing Stock Solutions

The following data is based on the product molecular weight 626.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.6 mL 7.98 mL 15.97 mL
5 mM 0.32 mL 1.6 mL 3.19 mL
10 mM 0.16 mL 0.8 mL 1.6 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Ko et al (2007) Structure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptor. J.Med.Chem. 50 2030 PMID: 17407275


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Keywords: MRS 2690, MRS 2690 supplier, Potent, P2Y14, agonists, Receptors, Purinergic, purinoceptors, MRS2690, P2Y, 2915, Tocris Bioscience

1 Citation for MRS 2690

Citations are publications that use Tocris products. Selected citations for MRS 2690 include:

Gao et al (2013) The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Neuropsychopharmacology 9 31 PMID: 22825617


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Reviews for MRS 2690

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P2Y14 agonist.
By Anonymous on 09/20/2018
Assay Type: Ex Vivo
Species: Mouse

P2Y14 activation.


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