PSB 0739

Pricing Availability   Qty
Description: Highly potent P2Y12 antagonist
Chemical Name: 1-Amino-9,10-dihydro-9,10-dioxo-4-[[4-(phenylamino)-3-sulfophenyl]amino]-2-anthracenesulfonic acid sodium salt
Purity: ≥95% (HPLC)
Datasheet
Citations (9)
Reviews (2)
Literature (5)

Biological Activity for PSB 0739

PSB 0739 is a highly potent P2Y12 receptor antagonist (Ki = 24.9 nM). Unlike clopidogrel (Cat. No. 2490), does not require bioactivation.

Licensing Information

Sold with the permission of the University of Bonn.

Technical Data for PSB 0739

M. Wt 609.54
Formula C26H17N3Na2O8S2
Storage Desiccate at RT
Purity ≥95% (HPLC)
CAS Number 1052087-90-7
PubChem ID 44583582
InChI Key QBLLYXXXOJUNCV-UHFFFAOYSA-L
Smiles [Na+].[Na+].NC1=C(C=C(NC2=CC(=C(NC3=CC=CC=C3)C=C2)S([O-])(=O)=O)C2=C1C(=O)C1=CC=CC=C1C2=O)S([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PSB 0739

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 15.24 25

Preparing Stock Solutions for PSB 0739

The following data is based on the product molecular weight 609.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 6.56 mL 32.81 mL 65.62 mL
1.25 mM 1.31 mL 6.56 mL 13.12 mL
2.5 mM 0.66 mL 3.28 mL 6.56 mL
12.5 mM 0.13 mL 0.66 mL 1.31 mL

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Product Datasheets for PSB 0739

Certificate of Analysis / Product Datasheet
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References for PSB 0739

References are publications that support the biological activity of the product.

Hoffmann et al (2009) Interaction of new, very potent non-nucleotide antagonists with Arg256 of the human platelet P2Y12 receptor. J.Pharmacol.Exp.Ther. 331 648 PMID: 19690189

Baqi et al (2009) High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors. J.Med.Chem. 52 3784 PMID: 19463000

Felix et al (2011) Development of a comprehensive set of P2 receptor pharmacological research compounds. Purinerg.Sig. 8 101 PMID: 22052555


If you know of a relevant reference for PSB 0739, please let us know.

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Keywords: PSB 0739, PSB 0739 supplier, PSB0739, potent, selective, p2y12, purine, receptors, antagonists, purinoceptors, purinergic, antagonises, inhibitors, inhibits, Purinergic, P2Y, Receptors, 3983, Tocris Bioscience

9 Citations for PSB 0739

Citations are publications that use Tocris products. Selected citations for PSB 0739 include:

Cserép et al (2020) Microglia Monitor and Protect Neuronal Function Through Specialized Somatic Purinergic Junctions. Science 367 528 PMID: 31831638

Uderhardt et al (2019) Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell 177 541 PMID: 30955887

Wang et al (2014) Nucleolin down-regulation is involved in ADP-induced cell cycle arrest in S phase and cell apoptosis in vascular endothelial cells. PLoS One 9 e110101 PMID: 25290311

Takayama et al (2016) Diurnal dynamic behavior of microglia in response to infected bacteria through the UDP-P2Y6 receptor system Scientific Reports 6 30006 PMID: 27445174


Do you know of a great paper that uses PSB 0739 from Tocris? Please let us know.

Reviews for PSB 0739

Average Rating: 4 (Based on 2 Reviews.)

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Good inhibitor.
By Anonymous on 06/06/2020
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: phagocyte

H20; dilution 10 μM

review image

P2Y12 blocker.
By Anonymous on 01/30/2018
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: acute brain slice

Used to block P2Y12 in acute brain slices. Monitored was the motility of microglia. No significant effect was found.


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