MAPK Family

MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of cellular functions.

Targets
Literature
Pathways
Receptor Data

MAPK Family Target Files

Six groups of MAPK have so far been identified:

  1. Extracellular signal-regulated kinases (ERK1, ERK2).
  2. c-Jun N-terminal kinases (JNKs)
  3. p38 isoforms (MAPK11, MAPK12, MAPK13, MAPK14)
  4. ERK5 (MAPK7)
  5. ERK3 (MAPK6) and ERK4 (MAPK4)
  6. ERK7/8 (MAPK15)

ERK 1 and ERK 2 transduce signals from growth factors and are key in regulating differentiation and proliferation in many cell types. Upon activation by MEK, ERK1 and 2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream kinases such as p90 RSK. JNK 1,2 and 3 (sometimes known as SAPKs or stress-activated kinases) and the p38 MAPKs (α-, β-, δ and γ- isoforms) are activated by UV irradiation, inflammatory cytokines and hyperosmolarity. The p38 MAPKs are also activated by lipopolysaccharide. Dysregulation of MAPK kinase pathways has been associated with various diseases including cancer (ERK), neurodegeneration (JNK) and inflammation (p38).

Literature for MAPK Family

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Learning & Memory

Learning & Memory Poster

Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.

Schizophrenia

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster highlights the targets and pathways representing the most promising strategies to pursue for novel drug development.

Pathways for MAPK Family

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.

MAPK Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
ERK1 Human MAPK3 NM_001040056 P27361
Mouse Mapk3 NM_011952 Q63844
Rat Mapk3 NM_017347 P21708
ERK2 Human MAPK1 NM_138957 P28482
Mouse Mapk1 NM_011949 P63085
Rat Mapk1 NM_053842 P63086
JNK1 Human MAPK8 NM_139049 P45983
Mouse Mapk8 NM_016700 Q91Y86
Rat Mapk8 L27129 P49185
JNK2 Human MAPK9 NM_139068 P45984
Mouse Mapk9 NM_016961 Q9WTU6
Rat Mapk9 NM_017322 P49186
JNK3 Human MAPK10 NM_138982 P53779
Mouse Mapk10 NM_009158 Q61831
Rat Mapk10 NM_012806 P49187
p38α Human MAPK14 NM_001315 Q16539
Mouse Mapk14 NM_011951 P47811
Rat Mapk14 NM_031020 P70618
p38β Human MAPK11 NM_002751 Q15759
Mouse Mapk11 NM_011161 Q9WUI1
p38δ Human MAPK13 NM_002754 O15264
Mouse Mapk13 NM_011950 Q9Z1B7
Rat Mapk13 NM_019231 Q32Q45
p38γ Human MAPK12 NM_002969 P53778
Mouse Mapk12 NM_013871 O08911
Rat Mapk12 NM_021746 Q63538
ERK5 Human MAPK7 NM_002749 Q13164
Mouse Mapk7 NM_011841 Q9WVS8
Rat Mapk7 AJ005424 O89037
ERK3 Human MAPK6 NM_002748 Q16659
Mouse Mapk6 NM_027418 Q61532
Rat Mapk6 NM_031622 P27704
ERK4 Human MAPK4 NM_002747 P31152
Mouse Mapk4 NM_172632 Q6P5G0
Rat Mapk4 NM_031622 P27704
ERK7/8 Human MAPK15 NM_139021 Q8TD08
Mouse Mapk15 NM_177922 Q80Y86
Rat Mapk15 NM_173331 Q9Z2A6