MRS 2693 trisodium salt

Pricing Availability   Qty
Cat.No. 2502 - MRS 2693 trisodium salt | C9H10IN2Na3O12P2 | CAS No. 1448858-83-0
Description: Selective P2Y6 agonist
Alternative Names: 5-Iodo-UDP trisodium salt
Chemical Name: 5-Iodouridine-5'-O-diphosphate trisodium salt
Purity: ≥95% (HPLC)
Citations (4)
Literature (5)

Biological Activity

Selective P2Y6 agonist (EC50 = 0.015 μM at the hP2Y6 receptor). Displays no activity at other P2Y subtypes. Exerts a cytoprotective effect in an in vivo mouse model of hindlimb skeletal muscle ischemia/reperfusion injury.

Technical Data

M. Wt 596
Formula C9H10IN2Na3O12P2
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1448858-83-0
PubChem ID 90488768
Smiles [Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])([O-])=O)N1C=C(I)C(=O)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble in water (supplied pre-dissolved at a concentration of 10mM)

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:


References are publications that support the biological activity of the product.

Besada et al (2006) Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. J.Med.Chem. 49 5532 PMID: 16942026

Mamedova et al (2008) Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation. Pharmacol.Res. 58 232 PMID: 18805489

Jacobson et al (2009) Development of selective agonists and antagonists of P2Y receptors. Purinerg.Sig. 5 75

If you know of a relevant reference for MRS 2693 trisodium salt, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Purinergic (P2Y) Receptor Agonists

Keywords: MRS 2693 trisodium salt, MRS 2693 trisodium salt supplier, Selective, P2Y6, purinergic, receptors, agonists, MRS2693, trisodium, salt, 5-Iodo-UDP, Purinergic, P2Y, Receptors, 2502, Tocris Bioscience

4 Citations for MRS 2693 trisodium salt

Citations are publications that use Tocris products. Selected citations for MRS 2693 trisodium salt include:

Yu et al (2013) Extracellular UDP enhances P2X-mediated bladder smooth muscle contractility via P2Y(6) activation of the phospholipase C/inositol trisphosphate pathway. FASEB J 27 1895 PMID: 23362118

Moreira-Souza et al (2015) Pyrimidinergic Receptor Activation Controls Toxoplasma gondii Infection in Macrophages. PLoS One 10 e0133502 PMID: 26192447

Matsumoto et al (2011) Uridine adenosine tetraphosphate-induced contraction is increased in renal but not pulmonary arteries from DOCA-salt hypertensive rats. Am J Physiol Heart Circ Physiol 301 H409 PMID: 21551273

Obba et al (2015) The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML. Neuropharmacology 11 1114 PMID: 26029847

Do you know of a great paper that uses MRS 2693 trisodium salt from Tocris? Please let us know.

Reviews for MRS 2693 trisodium salt

There are currently no reviews for this product. Be the first to review MRS 2693 trisodium salt and earn rewards!

Have you used MRS 2693 trisodium salt?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
P2X and P2Y Receptors

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.


Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.