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MRS 2693 trisodium salt is a selective P2Y6 agonist (EC50 = 0.015 μM at the hP2Y6 receptor). Displays no activity at other P2Y subtypes. Exerts a cytoprotective effect in an in vivo mouse model of hindlimb skeletal muscle ischemia/reperfusion injury.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble in water (supplied pre-dissolved at a concentration of 10mM)|
References are publications that support the biological activity of the product.
Besada et al (2006) Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. J.Med.Chem. 49 5532 PMID: 16942026
Mamedova et al (2008) Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation. Pharmacol.Res. 58 232 PMID: 18805489
Jacobson et al (2009) Development of selective agonists and antagonists of P2Y receptors. Purinerg.Sig. 5 75
If you know of a relevant reference for MRS 2693 trisodium salt, please let us know.
Keywords: MRS 2693 trisodium salt, MRS 2693 trisodium salt supplier, Selective, P2Y6, purinergic, receptors, agonists, MRS2693, trisodium, salt, 5-Iodo-UDP, Purinergic, P2Y, Receptors, 2502, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for MRS 2693 trisodium salt include:
Obba et al (2015) The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML. Neuropharmacology 11 1114 PMID: 26029847
Moreira-Souza et al (2015) Pyrimidinergic Receptor Activation Controls Toxoplasma gondii Infection in Macrophages. PLoS One 10 e0133502 PMID: 26192447
Yu et al (2013) Extracellular UDP enhances P2X-mediated bladder smooth muscle contractility via P2Y(6) activation of the phospholipase C/inositol trisphosphate pathway. FASEB J 27 1895 PMID: 23362118
Matsumoto et al (2011) Uridine adenosine tetraphosphate-induced contraction is increased in renal but not pulmonary arteries from DOCA-salt hypertensive rats. Am J Physiol Heart Circ Physiol 301 H409 PMID: 21551273
Do you know of a great paper that uses MRS 2693 trisodium salt from Tocris? Please let us know.
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