AZD 1283

Pricing Availability Delivery Time Qty
Cat.No. 6085 - AZD 1283 | C23H26N4O5S | CAS No. 919351-41-0
Description: High affinity P2Y12 antagonist
Chemical Name: Ethyl 5-cyano-2-methyl-6-[4-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-1-piperidinyl]-3-pyridinecarboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity P2Y12 antagonist (Kd = 11 nM). Causes a dose-dependent increase in blood flow and inhibits ADP-induced platelet aggregation in vivo. Antithrombotic.

Technical Data

M. Wt 470.54
Formula C23H26N4O5S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 919351-41-0
PubChem ID 23649325
InChI Key NEMHKCNXXRQYRF-UHFFFAOYSA-N
Smiles CCOC(C1=CC(C#N)=C(N2CCC(C(NS(=O)(CC3=CC=CC=C3)=O)=O)CC2)N=C1C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 47.05 100

Preparing Stock Solutions

The following data is based on the product molecular weight 470.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.13 mL 10.63 mL 21.25 mL
5 mM 0.43 mL 2.13 mL 4.25 mL
10 mM 0.21 mL 1.06 mL 2.13 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Bach et al (2013) Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283. J.Med.Chem. 56 7015 PMID: 23899349

Zhang et al (2014) Agonist-bound structure of the human P2Y12 receptor. Nature 509 119 PMID: 24784220

Zhang et al (2014) Structure of the human P2Y12 receptor in complex with an antithrombotic drug. Nature 509 115 PMID: 24670650


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Citations for AZD 1283

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