ERK

Extracellular signal-regulated kinases are a group of mitogen-activated protein kinases (MAPK) that mediate intracellular signaling. ERK1 and ERK2 (MAPK3 and MAPK1) transduce signals from growth factors and phorbol esters. They are expressed in all tissues, at varying levels.

Products
Background
Literature
Pathways
Gene Data

Inhibitors

Cat No Product Name / Activity
5843 AX 15836
Potent and selective ERK5 inhibitor
4842 BIX 02189
Selective MEK5 and ERK5 inhibitor
5393 ERK5-IN-1
Potent and selective ERK5 inhibitor
3706 FR 180204
Selective ERK inhibitor
4433 Pluripotin
Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal
4465 TCS ERK 11e
Potent and selective ERK2 inhibitor
3675 TMCB
Dual-kinase inhibitor; inhibits CK2 and ERK8
4132 XMD 8-92
ERK5/BMK1 inhibitor; also BRD4 inhibitor

Other

Cat No Product Name / Activity
5774 DEL 22379
ERK dimerization inhibitor
5979 Eicosapentaenoic Acid
Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation

Extracellular signal-regulated kinases are a group of mitogen-activated protein kinases (MAPK) that mediate intracellular signaling. ERK1 and ERK2 (MAPK3 and MAPK1) transduce signals from growth factors and phorbol esters. They are expressed in all tissues, at varying levels. Upon activation by MEK, ERK1 and 2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream kinases such as p90 RSK.

Activation of an ERK signaling pathway often involves regulation of cell division, migration and survival; dysregulation of these pathways has been associated with various diseases, including cancer. ERK signaling has also been linked to the positive regulation of synaptic plasticity and long-term potentiation (LTP).

Literature for ERK

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for ERK

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.

ERK Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
ERK1 Human MAPK3 NM_001040056 P27361
Mouse Mapk3 NM_011952 Q63844
Rat Mapk3 NM_017347 P21708
ERK2 Human MAPK1 NM_138957 P28482
Mouse Mapk1 NM_011949 P63085
Rat Mapk1 NM_053842 P63086
ERK3 Human MAPK6 NM_002748 Q16659
Mouse Mapk6 NM_027418 Q61532
Rat Mapk6 NM_031622 P27704
ERK4 Human MAPK4 NM_002747 P31152
Mouse Mapk4 NM_172632 Q6P5G0
Rat Mapk4 NM_031622 P27704
ERK5 Human MAPK7 NM_002749 Q13164
Mouse Mapk7 NM_011841 Q9WVS8
Rat Mapk7 AJ005424 O89037
ERK7/8 Human MAPK15 NM_139021 Q8TD08
Mouse Mapk15 NM_177922 Q80Y86
Rat Mapk15 NM_173331 Q9Z2A6