ATPγS tetralithium salt

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Cat.No. 4080 - ATPgammaS tetralithium salt | C10H12Li4N5O12P3S | CAS No. 93839-89-5
Description: Non-selective P2 agonist; analog of ATP (Cat. No. 3245)
Alternative Names: ATP-γS
Chemical Name: Adenosine-5'-(γ-thio)-triphosphate tetralithium salt
Purity: ≥90% (HPLC)
Datasheet
Citations (4)
Reviews
Literature (5)

Biological Activity for ATPγS tetralithium salt

ATPγS tetralithium salt is a P2 purinergic receptor agonist. Nonhydrolyzable analog of ATP (Cat. No. 3245).

Technical Data for ATPγS tetralithium salt

M. Wt 546.98
Formula C10H12Li4N5O12P3S
Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 93839-89-5
PubChem ID 5311341
InChI Key DWQFDOIBOYDYKH-KWIZKVQNSA-J
Smiles NC1=C2C(N([C@@H]3O[C@H](COP(OP(OP([O-])([O-])=S)([O-])=O)([O-])=O)[C@@H](O)[C@H]3O)C=N2)=NC=N1.[Li+].[Li+].[Li+].[Li+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ATPγS tetralithium salt

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 27.35 50

Preparing Stock Solutions for ATPγS tetralithium salt

The following data is based on the product molecular weight 546.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.66 mL 18.28 mL 36.56 mL
2.5 mM 0.73 mL 3.66 mL 7.31 mL
5 mM 0.37 mL 1.83 mL 3.66 mL
25 mM 0.07 mL 0.37 mL 0.73 mL

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Product Datasheets for ATPγS tetralithium salt

Certificate of Analysis / Product Datasheet
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References for ATPγS tetralithium salt

References are publications that support the biological activity of the product.

Evans et al (1995) Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2X purinoceptors). Mol.Pharmacol. 48 178 PMID: 7544432

Peck and Herschlag (2003) Adenosine 5'-O-(3-thio)triphosphate (ATPgammaS) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor elF4A. RNA 9 1180 PMID: 13130132

Chrysogelos et al (1983) The structure of recA protein-DNA filaments. 2 recA protein monomers unwind 17 base pairs of DNA by 11.5 degrees/base pair in the presence of adenosine 5'-O-(3-thiotriphosphate). J.Biol.Chem. 258 12624 PMID: 6313668


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View all Purinergic (P2X) Receptor Agonists

Keywords: ATPgammaS tetralithium salt, ATPgammaS tetralithium salt supplier, ATPgammaS, ATPγ, ATPgS, ATP, analogs, purinergic, receptors, p2x, p2y, purinoceptors, agonists, ATP-gS, ATP-yS, P2X, Receptors, Purinergic, P2Y, 4080, Tocris Bioscience

4 Citations for ATPγS tetralithium salt

Citations are publications that use Tocris products. Selected citations for ATPγS tetralithium salt include:

Miguel Cruz & Beall et al (2020) Extracellular ATP Increases Glucose Metabolism in Skeletal Muscle Cells in a P2 Receptor Dependent Manner but Does Not Contribute to Palmitate-Induced Insulin Resistance Front Physiol 11 PMID: 33101053

Aho et al (2016) Extracellular ATP protects endothelial cells against DNA damage. Purinergic Signal 12 575 PMID: 27030122

Gault et al (2014) Osmotic surveillance mediates rapid wound closure through nucleotide release. J Cell Biol 207 767 PMID: 25533845

Handly & Wollman (2017) Wound-induced Ca2+ wave propagates through a simple release and diffusion mechanism. Mol Biol Cell 28 1457 PMID: 28404746


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Literature in this Area

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