ATPγS tetralithium salt

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Cat.No. 4080 - ATPgammaS tetralithium salt | C10H12Li4N5O12P3S | CAS No. 93839-89-5
Description: P2 agonist; ATP (Cat. No. 3245) analog
Alternative Names: ATP-γS
Chemical Name: Adenosine-5'-(γ-thio)-triphosphate tetralithium salt
Purity: ≥90% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

P2 purinergic receptor agonist. Nonhydrolyzable analog of ATP (Cat. No. 3245).

Technical Data

M. Wt 546.98
Formula C10H12Li4N5O12P3S
Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 93839-89-5
PubChem ID 5311341
InChI Key DWQFDOIBOYDYKH-KWIZKVQNSA-J
Smiles NC1=C2C(N([C@@H]3O[C@H](COP(OP(OP([O-])([O-])=S)([O-])=O)([O-])=O)[C@@H](O)[C@H]3O)C=N2)=NC=N1.[Li+].[Li+].[Li+].[Li+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 27.35 50

Preparing Stock Solutions

The following data is based on the product molecular weight 546.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.83 mL 9.14 mL 18.28 mL
5 mM 0.37 mL 1.83 mL 3.66 mL
10 mM 0.18 mL 0.91 mL 1.83 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Evans et al (1995) Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2X purinoceptors). Mol.Pharmacol. 48 178 PMID: 7544432

Peck and Herschlag (2003) Adenosine 5'-O-(3-thio)triphosphate (ATPgammaS) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor elF4A. RNA 9 1180 PMID: 13130132

Chrysogelos et al (1983) The structure of recA protein-DNA filaments. 2 recA protein monomers unwind 17 base pairs of DNA by 11.5 degrees/base pair in the presence of adenosine 5'-O-(3-thiotriphosphate). J.Biol.Chem. 258 12624 PMID: 6313668


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1 Citation for ATPγS tetralithium salt

Citations are publications that use Tocris products. Selected citations for ATPγS tetralithium salt include:

Gault et al (2014) Osmotic surveillance mediates rapid wound closure through nucleotide release. J Cell Biol 207 767 PMID: 25533845


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