ATP disodium salt

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Cat.No. 3245 - ATP disodium salt | C10H14N5Na2O13P3 | CAS No. 987-65-5
Description: P2 agonist
Chemical Name: Adenosine 5'-triphosphate disodium salt
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews (5)
Literature

Biological Activity

P2 purinoceptor agonist.

Technical Data

M. Wt 551.14
Formula C10H14N5Na2O13P3
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 987-65-5
PubChem ID 13803
InChI Key TTWYZDPBDWHJOR-IDIVVRGQSA-L
Smiles O[C@@H]1[C@@H](COP(OP(OP(O)([O-])=O)([O-])=O)(O)=O)O[C@@H](N3C2=NC=NC(N)=C2N=C3)[C@@H]1O.[Na+].[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 55.11 100

Preparing Stock Solutions

The following data is based on the product molecular weight 551.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.81 mL 9.07 mL 18.14 mL
5 mM 0.36 mL 1.81 mL 3.63 mL
10 mM 0.18 mL 0.91 mL 1.81 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Gordon (1986) Extracellular ATP: effects, sources and fate. Biochem.J 233 309 PMID: 3006665

Guilbert et al (1998) Dependence of P2-nucleotide receptor agonist-mediated endothelium-indepdent relaxation on ectonucleotidase acticity and A2A-receptors in rat portal vein. Br.J.Pharm. 123 1732

Burnstock and Kenned (2006) Historical review: ATP as a neurotransmitter. Trends Pharm.Sci. 27 16


If you know of a relevant reference for ATP disodium salt, please let us know.

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Keywords: ATP disodium salt, ATP disodium salt supplier, P2, purinergic, agonists, P2X, Receptors, Purinergic, P2Y, purinoceptors, Adenosine, 5'-triphosphate, disodium, salt, 3245, Tocris Bioscience

3 Citations for ATP disodium salt

Citations are publications that use Tocris products. Selected citations for ATP disodium salt include:

Taheri et al (2017) Diversity of Evoked Astrocyte Ca2+ Dynamics Quantified through Experimental Measurements and Mathematical Modeling. Front Syst Neurosci 11 79 PMID: 29109680

Song et al (2015) Up-regulation of P2X7 receptors mediating proliferation of Schwann cells after sciatic nerve injury. Neuropharmacology 11 203 PMID: 25682129

Hannedouche et al (2013) Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells. Purinergic Signal 288 27434 PMID: 23940034


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Reviews for ATP disodium salt

Average Rating: 5 (Based on 5 Reviews.)

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great to use for the synthesis of complexes and for its use in biological assays.
By Anonymous on 07/02/2019
Species: Human

I used it to prepare a complex at 1mM concentration.

The product is highly soluble in water thus the most suitable solvent for it to use.


Kinase Assay ATP Kinetics.
By Brian Englar on 02/06/2019
Assay Type: In Vitro
Species: Human

Used this ATP for kinase assays with IRAK4 and a TAK1 inhibitor to determine Km and Vmax. Worked well with no issues and can freeze thaw with no issues.

review image

Great for kinase assays and kinetics.
By Scott Scarneo on 02/06/2019
Assay Type: In Vitro
Species: Human

I used this product for a kinase assay to look at enzyme kinetics. Worked great and was pure with no issues on solubility or contamination.

review image

Exreacellular ATP stimulates IL-1b production in macrophages.
By Chintan Koyani on 10/23/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Macrophages

RAW macrophages were incubated with ATP (5 mM) for 4 h to follow IL-1b mRNA expression using qPCR. ATP treatment induced inflammatory signalling in macrophages most likely via P2 receptor.

review image

P2 agonist.
By Anonymous on 05/17/2018
Assay Type: Ex Vivo
Species: Mouse

ATP, as expected, activates multiple P2 receptor responses, in cell culture and in brain slices.


Literature in this Area

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*Please note that Tocris will only send literature to established scientific business / institute addresses.


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