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ATP disodium salt
P2 purinoceptor agonist.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 551.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.81 mL||9.07 mL||18.14 mL|
|5 mM||0.36 mL||1.81 mL||3.63 mL|
|10 mM||0.18 mL||0.91 mL||1.81 mL|
|50 mM||0.04 mL||0.18 mL||0.36 mL|
References are publications that support the biological activity of the product.
Gordon (1986) Extracellular ATP: effects, sources and fate. Biochem.J 233 309 PMID: 3006665
Guilbert et al (1998) Dependence of P2-nucleotide receptor agonist-mediated endothelium-indepdent relaxation on ectonucleotidase acticity and A2A-receptors in rat portal vein. Br.J.Pharm. 123 1732
Burnstock and Kenned (2006) Historical review: ATP as a neurotransmitter. Trends Pharm.Sci. 27 16
If you know of a relevant reference for ATP disodium salt, please let us know.
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Keywords: ATP disodium salt, ATP disodium salt supplier, P2, purinergic, agonists, P2X, Receptors, Purinergic, P2Y, purinoceptors, Adenosine, 5'-triphosphate, disodium, salt, 3245, Tocris Bioscience
3 Citations for ATP disodium salt
Citations are publications that use Tocris products. Selected citations for ATP disodium salt include:
Taheri et al (2017) Diversity of Evoked Astrocyte Ca2+ Dynamics Quantified through Experimental Measurements and Mathematical Modeling. Front Syst Neurosci 11 79 PMID: 29109680
Song et al (2015) Up-regulation of P2X7 receptors mediating proliferation of Schwann cells after sciatic nerve injury. Neuropharmacology 11 203 PMID: 25682129
Hannedouche et al (2013) Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells. Purinergic Signal 288 27434 PMID: 23940034
Do you know of a great paper that uses ATP disodium salt from Tocris? Please let us know.
Reviews for ATP disodium salt
Average Rating: 5 (Based on 5 Reviews.)
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I used it to prepare a complex at 1mM concentration.
The product is highly soluble in water thus the most suitable solvent for it to use.
Used this ATP for kinase assays with IRAK4 and a TAK1 inhibitor to determine Km and Vmax. Worked well with no issues and can freeze thaw with no issues.
I used this product for a kinase assay to look at enzyme kinetics. Worked great and was pure with no issues on solubility or contamination.
RAW macrophages were incubated with ATP (5 mM) for 4 h to follow IL-1b mRNA expression using qPCR. ATP treatment induced inflammatory signalling in macrophages most likely via P2 receptor.
ATP, as expected, activates multiple P2 receptor responses, in cell culture and in brain slices.
Literature in this Area
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