NF 157

Pricing Availability   Qty
Description: Selective P2Y11 and P2X1 antagonist
Chemical Name: 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-fluoro-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
Purity: ≥90% (HPLC)
Datasheet
Citations (12)
Reviews
Literature (1)

Biological Activity for NF 157

NF 157 is a purinergic receptor antagonist that potently inhibits P2Y11 receptor activity (IC50 = 463 nM). Displays selectivity for P2Y11 and P2X1 receptors over P2Y1, P2Y2, P2X2, P2X3, P2X4 and P2X7 receptors. Inhibits NAD+-induced activation of human granulocytes.

This product is supplied with a high degree of hydration and some residual NaCl, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content and the maximum solubility threshold to use in dilution calculations.

Technical Data for NF 157

M. Wt 1437.08
Formula C49H28F2N6Na6O23S6
Storage Desiccate at RT
Purity ≥90% (HPLC)
CAS Number 104869-26-3
PubChem ID 71433548
InChI Key QJFCMJZVZFAWGF-UHFFFAOYSA-H
Smiles [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]OOSC1=C2C(NC(=O)C3=CC(NC(=O)C4=CC(NC(=O)NC5=CC(=CC=C5)C(=O)NC5=CC(=CC=C5F)C(=O)NC5=CC=C(C6=CC(=CC(=C56)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=C4)=C(F)C=C3)=CC=C(C2=CC(=C1)S([O-])(=O)=O)S([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NF 157

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 5 4
DMSO 10 7

Preparing Stock Solutions for NF 157

The following data is based on the product molecular weight 1437.08. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.07 mM 9.94 mL 49.7 mL 99.41 mL
0.35 mM 1.99 mL 9.94 mL 19.88 mL
0.7 mM 0.99 mL 4.97 mL 9.94 mL
3.5 mM 0.2 mL 0.99 mL 1.99 mL

Molarity Calculator

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Product Datasheets for NF 157

Certificate of Analysis / Product Datasheet
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References for NF 157

References are publications that support the biological activity of the product.

Ullmann et al (2005) Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency. J.Med.Chem. 48 7040 PMID: 16250663

Moreschi et al (2006) Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes. J.Biol.Chem. 281 31419 PMID: 16926152


If you know of a relevant reference for NF 157, please let us know.

View Related Products by Product Action

View all Purinergic (P2X) Receptor Antagonists

Keywords: NF 157, NF 157 supplier, Selective, P2Y11/P2X1, antagonists, Receptors, Purinergic, purinoceptors, NF157, antagonises, inhibitors, inhibits, P2X, P2Y, 2450, Tocris Bioscience

12 Citations for NF 157

Citations are publications that use Tocris products. Selected citations for NF 157 include:

Ledderose et al (2016) Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense. J Infect Dis 213 456 PMID: 26150546

Ren et al (2014) The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo. Emerg Microbes Infect 3 e62 PMID: 26038755

Kinoshita et al (2018) Anti-Depressant Flu Reveals its Therapeutic Effect Via Astrocytes. EBioMedicine 32 72 PMID: 29887330

Kawano et al (2015) Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors. PLoS One 10 e0127919 PMID: 26030257


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Reviews for NF 157

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.