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Adenylyl Cyclases

Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.

Products
Background
Literature (1)
Gene Data

Adenylyl Cyclase Inhibitors
Cat. No. Product Name / Activity
3834 KH 7
Selective soluble adenylyl cyclase inhibitor
5071 NKY 80
Adenylyl cyclase inhibitor
1586 SKF 83566 hydrobromide
Selectively inhibits AC2; also a potent, selective D1-like antagonist
1435 SQ 22536
Adenylyl cyclase inhibitor
6271 ST 034307
Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo

Adenylyl Cyclase Activators
Cat. No. Product Name / Activity
1603 NKH 477
Water-soluble adenylyl cyclase activator
1183 PACAP 1-27
Potently stimulates adenylyl cyclase
1186 PACAP 1-38
Potently stimulates adenylyl cyclase

Other
Cat. No. Product Name / Activity
1099 Forskolin
Adenylyl cyclase activator

Related Targets

Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC; nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and muscle, and one soluble form (sAC), which is expressed predominantly in the testes.

External sources of pharmacological information for Adenylyl Cyclases :

Literature for Adenylyl Cyclases

Tocris offers the following scientific literature for Adenylyl Cyclases to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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Adenylyl Cyclase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
AC1 Human ADCY1 NM_021116 Q08828
Mouse Adcy1 NM_009622 O88444
Rat Adcy1 NM_001107239 XP_223616
AC2 Human ADCY2 NM_020546 Q08462
Mouse Adcy2 NM_153534 Q80TL1
Rat Adcy2 NM_031007 P26769
AC3 Human ADCY3 NM_004036 O60266
Mouse Adcy3 NM_138305 Q8VHH7
Rat Acdy3 NM_130779 P21932
AC4 Human ADCY4 NM_139247 Q8NFM4
Mouse Adcy4 NM_080435 Q91WF3
Rat Adcy4 NM_019285 P26770
AC5 Human ADCY5 XM_171048 O95622
Mouse Adcy5 NM_001012765 P84309
Rat Adcy5 NM_022600 Q04400
AC6 Human ADCY6 NM_020983 O43306
Mouse Adcy6 NM_007405 Q01341
Rat Adcy6 NM_012821 Q03343
AC7 Human ADCY7 NM_001114 P51828
Mouse Adcy7 NM_007406 P51829
Rat Adcy7 XM_226333 Q9QZG8
AC8 Human ADCY8 NM_001115 P40145
Mouse Adcy8 NM_009623 P97490
Rat Adcy8 NM_017142 P40146
AC9 Human ADCY9 NM_001116 O60503
Mouse Adcy9 NM_009624 P51830
Rat Adcy9 NM_001106980 XP_220178
sAC Human ADCY10 NM_018417 Q96PN6
Mouse Adcy10 NM_173029 Q8C0T9
Rat Adcy10 NM_021684 Q9Z286