Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.
Adenylyl Cyclase Inhibitors |
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Cat. No. | Product Name / Activity |
3834 | KH 7 |
Selective soluble adenylyl cyclase inhibitor | |
5071 | NKY 80 |
Adenylyl cyclase inhibitor | |
1586 | SKF 83566 hydrobromide |
Selectively inhibits AC2; also a potent, selective D1-like antagonist | |
1435 | SQ 22536 |
Adenylyl cyclase inhibitor | |
6271 | ST 034307 |
Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo | |
Adenylyl Cyclase Activators |
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Cat. No. | Product Name / Activity |
1603 | NKH 477 |
Water-soluble adenylyl cyclase activator | |
1183 | PACAP 1-27 |
Potently stimulates adenylyl cyclase | |
1186 | PACAP 1-38 |
Potently stimulates adenylyl cyclase | |
Other |
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Cat. No. | Product Name / Activity |
1099 | Forskolin |
Adenylyl cyclase activator |
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC; nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and muscle, and one soluble form (sAC), which is expressed predominantly in the testes.
Tocris offers the following scientific literature for Adenylyl Cyclases to showcase our products. We invite you to request* your copy today!
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Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
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AC1 | Human | ADCY1 | NM_021116 | Q08828 |
Mouse | Adcy1 | NM_009622 | O88444 | |
Rat | Adcy1 | NM_001107239 | XP_223616 | |
AC2 | Human | ADCY2 | NM_020546 | Q08462 |
Mouse | Adcy2 | NM_153534 | Q80TL1 | |
Rat | Adcy2 | NM_031007 | P26769 | |
AC3 | Human | ADCY3 | NM_004036 | O60266 |
Mouse | Adcy3 | NM_138305 | Q8VHH7 | |
Rat | Acdy3 | NM_130779 | P21932 | |
AC4 | Human | ADCY4 | NM_139247 | Q8NFM4 |
Mouse | Adcy4 | NM_080435 | Q91WF3 | |
Rat | Adcy4 | NM_019285 | P26770 | |
AC5 | Human | ADCY5 | XM_171048 | O95622 |
Mouse | Adcy5 | NM_001012765 | P84309 | |
Rat | Adcy5 | NM_022600 | Q04400 | |
AC6 | Human | ADCY6 | NM_020983 | O43306 |
Mouse | Adcy6 | NM_007405 | Q01341 | |
Rat | Adcy6 | NM_012821 | Q03343 | |
AC7 | Human | ADCY7 | NM_001114 | P51828 |
Mouse | Adcy7 | NM_007406 | P51829 | |
Rat | Adcy7 | XM_226333 | Q9QZG8 | |
AC8 | Human | ADCY8 | NM_001115 | P40145 |
Mouse | Adcy8 | NM_009623 | P97490 | |
Rat | Adcy8 | NM_017142 | P40146 | |
AC9 | Human | ADCY9 | NM_001116 | O60503 |
Mouse | Adcy9 | NM_009624 | P51830 | |
Rat | Adcy9 | NM_001106980 | XP_220178 | |
sAC | Human | ADCY10 | NM_018417 | Q96PN6 |
Mouse | Adcy10 | NM_173029 | Q8C0T9 | |
Rat | Adcy10 | NM_021684 | Q9Z286 |