Adenylyl Cyclases

Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
3635 BPIPP
Non-competitive AC inhibitor. Also GC inhibitor
3834 KH 7
Selective soluble adenylyl cyclase inhibitor
1436 MDL 12330A hydrochloride
Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor
5071 NKY 80
Adenylyl cyclase inhibitor
1586 SKF 83566 hydrobromide
Selectively inhibits AC2; also a potent, selective D1-like antagonist
1435 SQ 22536
Adenylyl cyclase inhibitor
6271 ST 034307
Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo

Activators

Cat No Product Name / Activity
1099 Forskolin
Adenylyl cyclase activator
1603 NKH 477
Water-soluble adenylyl cyclase activator
1183 PACAP 1-27
Potently stimulates adenylyl cyclase
1186 PACAP 1-38
Potently stimulates adenylyl cyclase

Ligand-sets

Cat No Product Name / Activity
1882 PKA Tocriset™
Selection of 5 PKA modulators (Cat. Nos. 1337, 1140, 1099, 1288 and 1603)

Related Targets

Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC; nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and muscle, and one soluble form (sAC), which is expressed predominantly in the testes.

External sources of pharmacological information for Adenylyl Cyclases :

    Literature for Adenylyl Cyclases

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    Adenylyl Cyclase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    AC1 Human ADCY1 NM_021116 Q08828
    Mouse Adcy1 NM_009622 O88444
    Rat Adcy1 NM_001107239 XP_223616
    AC2 Human ADCY2 NM_020546 Q08462
    Mouse Adcy2 NM_153534 Q80TL1
    Rat Adcy2 NM_031007 P26769
    AC3 Human ADCY3 NM_004036 O60266
    Mouse Adcy3 NM_138305 Q8VHH7
    Rat Acdy3 NM_130779 P21932
    AC4 Human ADCY4 NM_139247 Q8NFM4
    Mouse Adcy4 NM_080435 Q91WF3
    Rat Adcy4 NM_019285 P26770
    AC5 Human ADCY5 XM_171048 O95622
    Mouse Adcy5 NM_001012765 P84309
    Rat Adcy5 NM_022600 Q04400
    AC6 Human ADCY6 NM_020983 O43306
    Mouse Adcy6 NM_007405 Q01341
    Rat Adcy6 NM_012821 Q03343
    AC7 Human ADCY7 NM_001114 P51828
    Mouse Adcy7 NM_007406 P51829
    Rat Adcy7 XM_226333 Q9QZG8
    AC8 Human ADCY8 NM_001115 P40145
    Mouse Adcy8 NM_009623 P97490
    Rat Adcy8 NM_017142 P40146
    AC9 Human ADCY9 NM_001116 O60503
    Mouse Adcy9 NM_009624 P51830
    Rat Adcy9 NM_001106980 XP_220178
    sAC Human ADCY10 NM_018417 Q96PN6
    Mouse Adcy10 NM_173029 Q8C0T9
    Rat Adcy10 NM_021684 Q9Z286