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AR-C 69931 tetrasodium salt
Highly potent P2Y12 antagonist (IC50 = 0.4 nM). Inhibits ADP-induced human platelet aggregation ex vivo. Reduces thrombus weight and delays thrombus formation in a model of carotid artery thrombosis in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 864.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.16 mL||5.79 mL||11.57 mL|
|5 mM||0.23 mL||1.16 mL||2.31 mL|
|10 mM||0.12 mL||0.58 mL||1.16 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
References are publications that support the biological activity of the product.
Huang et al (2000) Prevention of arterial thrombosis by intravenously administered platelet P2T receptor antagonist AR-C69931MX in a canine model. J.Pharmacol.Exp.Ther. 295 492 PMID: 11046080
Ingall et al (1999) Antagonists of the platelet P2T receptor: a novel approach to antithrombotic therapy. J.Med.Chem. 42 213 PMID: 9925726
Srinivasan et al (2009) The P2Y12 antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a Gi-independent increase in cAMP levels. J.Biol.Chem. 284 16108 PMID: 19346255
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