AR-C 69931 tetrasodium salt

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Description: Highly potent P2Y12 antagonist
Alternative Names: Cangrelor tetrasodium salt
Chemical Name: N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]adenosine-5'-O-(β,γ-dichloromethylene)triphosphate tetrasodium salt
Purity: ≥98% (HPLC)
Citations (6)
Literature (1)

Biological Activity for AR-C 69931 tetrasodium salt

AR-C 69931 tetrasodium salt is a highly potent P2Y12 antagonist (IC50 = 0.4 nM). Inhibits ADP-induced human platelet aggregation ex vivo. Reduces thrombus weight and delays thrombus formation in a model of carotid artery thrombosis in vivo.

Technical Data for AR-C 69931 tetrasodium salt

M. Wt 864.29
Formula C17H21Cl2F3N5Na4O12P3S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 163706-36-3
PubChem ID 10260031
Smiles O[C@@H]1[C@H](O)[C@@H](N2C3=NC(SCCC(F)(F)F)=NC(NCCSC)=C3N=C2)O[C@H]1COP(OP(C(Cl)(Cl)P(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AR-C 69931 tetrasodium salt

Solvent Max Conc. mg/mL Max Conc. mM
water 86.43 100

Preparing Stock Solutions for AR-C 69931 tetrasodium salt

The following data is based on the product molecular weight 864.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.16 mL 5.79 mL 11.57 mL
5 mM 0.23 mL 1.16 mL 2.31 mL
10 mM 0.12 mL 0.58 mL 1.16 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Product Datasheets for AR-C 69931 tetrasodium salt

References for AR-C 69931 tetrasodium salt

References are publications that support the biological activity of the product.

Huang et al (2000) Prevention of arterial thrombosis by intravenously administered platelet P2T receptor antagonist AR-C69931MX in a canine model. J.Pharmacol.Exp.Ther. 295 492 PMID: 11046080

Ingall et al (1999) Antagonists of the platelet P2T receptor: a novel approach to antithrombotic therapy. J.Med.Chem. 42 213 PMID: 9925726

Srinivasan et al (2009) The P2Y12 antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a Gi-independent increase in cAMP levels. J.Biol.Chem. 284 16108 PMID: 19346255

If you know of a relevant reference for AR-C 69931 tetrasodium salt, please let us know.

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6 Citations for AR-C 69931 tetrasodium salt

Citations are publications that use Tocris products. Selected citations for AR-C 69931 tetrasodium salt include:

Sally et al (2019) Promiscuous G-Protein-Coupled Receptor Inhibition of Transient Receptor Potential Melastatin 3 Ion Channels by Gβγ Subunits. J Neurosci 39 7840-7852 PMID: 31451581

Chris et al (2020) Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1. Elife 9 PMID: 33350386

Vivek et al (2020) Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531. Elife 9 PMID: 32667883

Yu et al (2020) Cancer associated fibroblast FAK regulates malignant cell metabolism. Nat Commun 11 1290 PMID: 32157087

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.