AR-C 69931 tetrasodium salt

Pricing Availability Delivery Time Qty
Cat.No. 5720 - AR-C 69931 tetrasodium salt | C17H21Cl2F3N5Na4O12P3S2 | CAS No. 163706-36-3
Description: Highly potent P2Y12 antagonist
Alternative Names: Cangrelor tetrasodium salt
Chemical Name: N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]adenosine-5'-O-(β,γ-dichloromethylene)triphosphate tetrasodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Highly potent P2Y12 antagonist (IC50 = 0.4 nM). Inhibits ADP-induced human platelet aggregation ex vivo. Reduces thrombus weight and delays thrombus formation in a model of carotid artery thrombosis in vivo.

Technical Data

M. Wt 864.29
Formula C17H21Cl2F3N5Na4O12P3S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 163706-36-3
PubChem ID 10260031
InChI Key COWWROCHWNGJHQ-OPKBHZIBSA-J
Smiles O[C@@H]1[C@H](O)[C@@H](N2C3=NC(SCCC(F)(F)F)=NC(NCCSC)=C3N=C2)O[C@H]1COP(OP(C(Cl)(Cl)P(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 86.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 864.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.16 mL 5.79 mL 11.57 mL
5 mM 0.23 mL 1.16 mL 2.31 mL
10 mM 0.12 mL 0.58 mL 1.16 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Huang et al (2000) Prevention of arterial thrombosis by intravenously administered platelet P2T receptor antagonist AR-C69931MX in a canine model. J.Pharmacol.Exp.Ther. 295 492 PMID: 11046080

Ingall et al (1999) Antagonists of the platelet P2T receptor: a novel approach to antithrombotic therapy. J.Med.Chem. 42 213 PMID: 9925726

Srinivasan et al (009 ) The P2Y12 antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a Gi-independent increase in cAMP levels. J.Biol.Chem. 284 16108 PMID: 19346255


If you know of a relevant reference for AR-C 69931 tetrasodium salt, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Purinergic (P2Y) Receptor Antagonists

Keywords: AR-C 69931 tetrasodium salt, supplier, ARC69931, tetrasodium, salt, P2Y12, P2T, potent, purinergic, antagonists, antagonism, antithrombotic, Cangrelor, tetrasodium, salt, Purinergic, P2Y, Receptors, Purinergic, P2Y, Receptors, Tocris Bioscience

Citations for AR-C 69931 tetrasodium salt

Citations are publications that use Tocris products.

Currently there are no citations for AR-C 69931 tetrasodium salt. Do you know of a great paper that uses AR-C 69931 tetrasodium salt from Tocris? If so please let us know.

AR-C 69931 tetrasodium salt Reviews

Average Rating:

(Based on 0 Reviews)


1 Star
0%
2 Star
0%
3 Star
0%
4 Star
0%
5 Star
0%

Have you used AR-C 69931 tetrasodium salt?

Submit a review and receive a $25US/€18/£15/$25CAN Amazon gift card if you include an image -$10US/€7/£6/$10CAN Amazon gift card for reviews without an image. Limited to verified customers in USA, Canada and Europe.


Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
P2X and P2Y Receptors

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.

Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.